Open Access

Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review)

  • Authors:
    • Tianyu Wang
    • Xiaobing Li
    • Ruijie Ma
    • Jian Sun
    • Shuhong Huang
    • Zhigang Sun
    • Meng Wang
  • View Affiliations

  • Published online on: February 21, 2024     https://doi.org/10.3892/ijo.2024.5627
  • Article Number: 39
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Neddylation, akin to ubiquitination, represents a post‑translational modification of proteins wherein neural precursor cell‑expressed developmentally downregulated protein 8 (NEDD8) is modified on the substrate protein through a series of reactions. Neddylation plays a pivotal role in the growth and proliferation of animal cells. In colorectal cancer (CRC), it predominantly contributes to the proliferation, metastasis and survival of tumor cells, decreasing overall patient survival. The strategic manipulation of the NEDD8‑mediated neddylation pathway holds immense therapeutic promise in terms of the potential to modulate the growth of tumors by regulating diverse biological responses within cancer cells, such as DNA damage response and apoptosis, among others. MLN4924 is an inhibitor of NEDD8, and its combined use with platinum drugs and irinotecan, as well as cycle inhibitors and NEDD activating enzyme inhibitors screened by drug repurposing, has been found to exert promising antitumor effects. The present review summarizes the recent progress made in the understanding of the role of NEDD8 in the advancement of CRC, suggesting that NEDD8 is a promising anti‑CRC target.
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April-2024
Volume 64 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Wang T, Li X, Ma R, Sun J, Huang S, Sun Z and Wang M: Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review). Int J Oncol 64: 39, 2024.
APA
Wang, T., Li, X., Ma, R., Sun, J., Huang, S., Sun, Z., & Wang, M. (2024). Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review). International Journal of Oncology, 64, 39. https://doi.org/10.3892/ijo.2024.5627
MLA
Wang, T., Li, X., Ma, R., Sun, J., Huang, S., Sun, Z., Wang, M."Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review)". International Journal of Oncology 64.4 (2024): 39.
Chicago
Wang, T., Li, X., Ma, R., Sun, J., Huang, S., Sun, Z., Wang, M."Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review)". International Journal of Oncology 64, no. 4 (2024): 39. https://doi.org/10.3892/ijo.2024.5627