Open Access

Chimeric antigen receptor T cells in the treatment of osteosarcoma (Review)

  • Authors:
    • Tong Yu
    • Weibo Jiang
    • Yang Wang
    • Ying Zhou
    • Jianhang Jiao
    • Minfei Wu
  • View Affiliations

  • Published online on: February 22, 2024     https://doi.org/10.3892/ijo.2024.5628
  • Article Number: 40
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma (OS) is a frequently occurring primary bone tumor, mostly affecting children, adolescents and young adults. Before 1970, surgical resection was the main treatment method for OS, but the clinical results were not promising. Subsequently, the advent of chemotherapy has improved the prognosis of patients with OS. However, there is still a high incidence of metastasis or recurrence, and chemotherapy has several side effects, thus making the 5‑year survival rate markedly low. Recently, chimeric antigen receptor T (CAR‑T) cell therapy represents an alternative immunotherapy approach with significant potential for hematologic malignancies. Nevertheless, the application of CAR‑T cells in the treatment of OS faces numerous challenges. The present review focused on the advances in the development of CAR‑T cells to improve their clinical efficacy, and discussed ways to overcome the difficulties faced by CAR T‑cell therapy for OS.
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April-2024
Volume 64 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Yu T, Jiang W, Wang Y, Zhou Y, Jiao J and Wu M: Chimeric antigen receptor T cells in the treatment of osteosarcoma (Review). Int J Oncol 64: 40, 2024.
APA
Yu, T., Jiang, W., Wang, Y., Zhou, Y., Jiao, J., & Wu, M. (2024). Chimeric antigen receptor T cells in the treatment of osteosarcoma (Review). International Journal of Oncology, 64, 40. https://doi.org/10.3892/ijo.2024.5628
MLA
Yu, T., Jiang, W., Wang, Y., Zhou, Y., Jiao, J., Wu, M."Chimeric antigen receptor T cells in the treatment of osteosarcoma (Review)". International Journal of Oncology 64.4 (2024): 40.
Chicago
Yu, T., Jiang, W., Wang, Y., Zhou, Y., Jiao, J., Wu, M."Chimeric antigen receptor T cells in the treatment of osteosarcoma (Review)". International Journal of Oncology 64, no. 4 (2024): 40. https://doi.org/10.3892/ijo.2024.5628