Open Access

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)

  • Authors:
    • Jinzhe Sun
    • Shiqian Chen
    • Dan Zang
    • Hetian Sun
    • Yan Sun
    • Jun Chen
  • View Affiliations

  • Published online on: February 29, 2024     https://doi.org/10.3892/ijo.2024.5632
  • Article Number: 44
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is one of the leading causes of mortality worldwide. The etiology of cancer has not been fully elucidated yet, and further enhancements are necessary to optimize therapeutic efficacy. Butyrate, a short‑chain fatty acid, is generated through gut microbial fermentation of dietary fiber. Studies have unveiled the relevance of butyrate in malignant neoplasms, and a comprehensive understanding of its role in cancer is imperative for realizing its full potential in oncological treatment. Its full antineoplastic effects via the activation of G protein‑coupled receptors and the inhibition of histone deacetylases have been also confirmed. However, the underlying mechanistic details remain unclear. The present study aimed to review the involvement of butyrate in carcinogenesis and its molecular mechanisms, with a particular emphasis on its association with the efficacy of tumor immunotherapy, as well as discussing relevant clinical studies on butyrate as a therapeutic target for neoplastic diseases to provide new insights into cancer treatment.
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April-2024
Volume 64 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Sun J, Chen S, Zang D, Sun H, Sun Y and Chen J: Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review). Int J Oncol 64: 44, 2024.
APA
Sun, J., Chen, S., Zang, D., Sun, H., Sun, Y., & Chen, J. (2024). Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review). International Journal of Oncology, 64, 44. https://doi.org/10.3892/ijo.2024.5632
MLA
Sun, J., Chen, S., Zang, D., Sun, H., Sun, Y., Chen, J."Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)". International Journal of Oncology 64.4 (2024): 44.
Chicago
Sun, J., Chen, S., Zang, D., Sun, H., Sun, Y., Chen, J."Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)". International Journal of Oncology 64, no. 4 (2024): 44. https://doi.org/10.3892/ijo.2024.5632