Open Access

Current data and future perspectives on DNA methylation in ovarian cancer (Review)

  • Authors:
    • Mengyu Fu
    • Fengying Deng
    • Jie Chen
    • Li Fu
    • Jiahui Lei
    • Ting Xu
    • Youguo Chen
    • Jinhua Zhou
    • Qinqin Gao
    • Hongmei Ding
  • View Affiliations

  • Published online on: May 8, 2024     https://doi.org/10.3892/ijo.2024.5650
  • Article Number: 62
  • Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ovarian cancer (OC) represents the most prevalent malignancy of the female reproductive system. Its distinguishing features include a high aggressiveness, substantial morbidity and mortality, and a lack of apparent symptoms, which collectively pose significant challenges for early detection. Given that aberrant DNA methylation events leading to altered gene expression are characteristic of numerous tumor types, there has been extensive research into epigenetic mechanisms, particularly DNA methylation, in human cancers. In the context of OC, DNA methylation is often associated with the regulation of critical genes, such as BRCA1/2 and Ras‑association domain family 1A. Methylation modifications within the promoter regions of these genes not only contribute to the pathogenesis of OC, but also induce medication resistance and influence the prognosis of patients with OC. As such, a more in‑depth understanding of DNA methylation underpinning carcinogenesis could potentially facilitate the development of more effective therapeutic approaches for this intricate disease. The present review focuses on classical tumor suppressor genes, oncogenes, signaling pathways and associated microRNAs in an aim to elucidate the influence of DNA methylation on the development and progression of OC. The advantages and limitations of employing DNA methylation in the diagnosis, treatment and prevention of OC are also discussed. On the whole, the present literature review indicates that the DNA methylation of specific genes could potentially serve as a prognostic biomarker for OC and a therapeutic target for personalized treatment strategies. Further investigations in this field may yield more efficacious diagnostic and therapeutic alternatives for patients with OC.
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June-2024
Volume 64 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Fu M, Deng F, Chen J, Fu L, Lei J, Xu T, Chen Y, Zhou J, Gao Q, Ding H, Ding H, et al: Current data and future perspectives on DNA methylation in ovarian cancer (Review). Int J Oncol 64: 62, 2024.
APA
Fu, M., Deng, F., Chen, J., Fu, L., Lei, J., Xu, T. ... Ding, H. (2024). Current data and future perspectives on DNA methylation in ovarian cancer (Review). International Journal of Oncology, 64, 62. https://doi.org/10.3892/ijo.2024.5650
MLA
Fu, M., Deng, F., Chen, J., Fu, L., Lei, J., Xu, T., Chen, Y., Zhou, J., Gao, Q., Ding, H."Current data and future perspectives on DNA methylation in ovarian cancer (Review)". International Journal of Oncology 64.6 (2024): 62.
Chicago
Fu, M., Deng, F., Chen, J., Fu, L., Lei, J., Xu, T., Chen, Y., Zhou, J., Gao, Q., Ding, H."Current data and future perspectives on DNA methylation in ovarian cancer (Review)". International Journal of Oncology 64, no. 6 (2024): 62. https://doi.org/10.3892/ijo.2024.5650