Open Access

Microbial metabolites affect tumor progression, immunity and therapy prediction by reshaping the tumor microenvironment (Review)

  • Authors:
    • Yuhang Zhou
    • Wenjie Han
    • Yun Feng
    • Yue Wang
    • Tao Sun
    • Junnan Xu
  • View Affiliations

  • Published online on: June 6, 2024     https://doi.org/10.3892/ijo.2024.5661
  • Article Number: 73
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Several studies have indicated that the gut microbiome and tumor microbiota may affect tumors. Emerging metabolomics research illustrates the need to examine the variations in microbial metabolite composition between patients with cancer and healthy individuals. Microbial metabolites can impact the progression of tumors and the immune response by influencing a number of mechanisms, including modulation of the immune system, cancer or immune‑related signaling pathways, epigenetic modification of proteins and DNA damage. Microbial metabolites can also alleviate side effects and drug resistance during chemotherapy and immunotherapy, while effectively activating the immune system to exert tumor immunotherapy. Nevertheless, the impact of microbial metabolites on tumor immunity can be both beneficial and harmful, potentially influenced by the concentration of the metabolites or the specific cancer type. The present review summarizes the roles of various microbial metabolites in different solid tumors, alongside their influence on tumor immunity and treatment. Additionally, clinical trials evaluating the therapeutic effects of microbial metabolites or related microbes on patients with cancer have been listed. In summary, studying microbial metabolites, which play a crucial role in the interaction between the microbiota and tumors, could lead to the identification of new supplementary treatments for cancer. This has the potential to improve the effectiveness of cancer treatment and enhance patient prognosis.
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July-2024
Volume 65 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou Y, Han W, Feng Y, Wang Y, Sun T and Xu J: Microbial metabolites affect tumor progression, immunity and therapy prediction by reshaping the tumor microenvironment (Review). Int J Oncol 65: 73, 2024.
APA
Zhou, Y., Han, W., Feng, Y., Wang, Y., Sun, T., & Xu, J. (2024). Microbial metabolites affect tumor progression, immunity and therapy prediction by reshaping the tumor microenvironment (Review). International Journal of Oncology, 65, 73. https://doi.org/10.3892/ijo.2024.5661
MLA
Zhou, Y., Han, W., Feng, Y., Wang, Y., Sun, T., Xu, J."Microbial metabolites affect tumor progression, immunity and therapy prediction by reshaping the tumor microenvironment (Review)". International Journal of Oncology 65.1 (2024): 73.
Chicago
Zhou, Y., Han, W., Feng, Y., Wang, Y., Sun, T., Xu, J."Microbial metabolites affect tumor progression, immunity and therapy prediction by reshaping the tumor microenvironment (Review)". International Journal of Oncology 65, no. 1 (2024): 73. https://doi.org/10.3892/ijo.2024.5661