Role of miRNA‑122 in cancer (Review)
- Authors:
- Jing Zhang
- Linghua Wu
- Rong Ding
- Xin Deng
- Zeshan Chen
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Affiliations: Department of Respiratory Medicine, Taizhou Fourth People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Traditional Chinese Medicine, Taizhou Fifth People's Hospital, Taizhou, Jiangsu 225766, P.R. China, School of Basic Medical Sciences, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530200, P.R. China, Department of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region People's Hospital, Nanning, Guangxi 530016, P.R. China - Published online on: July 18, 2024 https://doi.org/10.3892/ijo.2024.5671
- Article Number: 83
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Mattiuzzi C and Lippi G: Current cancer epidemiology. J Epidemiol Glob Health. 9:217–222. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Britton C, Laing R and Devaney E: Small RNAs in parasitic nematodes-forms and functions. Parasitology. 147:855–864. 2020. View Article : Google Scholar | |
|
Morales-Martínez M and Vega MI: Role of MicroRNA-7 (MiR-7) in cancer physiopathology. Int J Mol Sci. 23:90912022. View Article : Google Scholar : PubMed/NCBI | |
|
Hebbar S, Panzade G, Vashisht AA, Wohlschlegel JA, Veksler-Lublinsky I and Zinovyeva AY: Functional identification of microRNA-centered complexes in C: elegans. Sci Rep. 12:71332022. View Article : Google Scholar | |
|
Hill M and Tran N: miRNA interplay: Mechanisms and consequences in cancer. Dis Model Mech. 14:dmm0476622021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y and Wang X: miRDB: An online database for prediction of functional microRNA targets. Nucleic Acids Res. 48(D1): D127–D131. 2020. View Article : Google Scholar : | |
|
Wang Y, Xing QF, Liu XQ, Guo ZJ, Li CY and Sun G: MiR-122 targets VEGFC in bladder cancer to inhibit tumor growth and angiogenesis. Am J Transl Res. 8:3056–3066. 2016.PubMed/NCBI | |
|
Chun KH: Molecular Targets and signaling pathways of microRNA-122 in hepatocellular carcinoma. Pharmaceutics. 14:13802022. View Article : Google Scholar : PubMed/NCBI | |
|
Collison AM, Sokulsky LA, Kepreotes E, Pereira de Siqueira A, Morten M, Edwards MR, Walton RP, Bartlett NW, Yang M, Nguyen TH, et al: miR-122 promotes virus-induced lung disease by targeting SOCS1. JCI Insight. 6:e1279332021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang M, Zheng H, Zhou X, Zhang J and Shao G: miR-122 promotes diabetic retinopathy through targeting TIMP3. Anim Cells Syst (Seoul). 24:275–281. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Scott KM, Cohen DJ, Boyan BD and Schwartz Z: miR-122 and the WNT/β-catenin pathway inhibit effects of both interleukin-1β and tumor necrosis factor-α in articular chondrocytes in vitro. J Cell Biochem. 123:1053–1063. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Li A, Wu J, Zhai A, Qian J, Qian J, Wang X, Qaria MA, Zhang Q, Li Y, Fang Y, Kao W, et al: HBV triggers APOBEC2 expression through miR-122 regulation and affects the proliferation of liver cancer cells. Int J Oncol. 55:1137–1148. 2019.PubMed/NCBI | |
|
Smolarz B, Durczyński A, Romanowicz H, Szyłło K and Hogendorf P: miRNAs in cancer (review of literature). Int J Mol Sci. 23:28052022. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Song JW, Lin JY, Miao R and Zhong JC: Roles of MicroRNA-122 in cardiovascular fibrosis and related diseases. Cardiovasc Toxicol. 20:463–473. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Guo L, Yin M and Wang Y: CREB1, a direct target of miR-122, promotes cell proliferation and invasion in bladder cancer. Oncol Lett. 16:3842–3848. 2018.PubMed/NCBI | |
|
Qin H, Sha J, Jiang C, Gao X, Qu L, Yan H, Xu T, Jiang Q and Gao H: miR-122 inhibits metastasis and epithelial-mesenchymal transition of non-small-cell lung cancer cells. Onco Targets Ther. 8:3175–3184. 2015.PubMed/NCBI | |
|
Chandimali N, Huynh DL, Zhang JJ, Lee JC, Yu DY, Jeong DK and Kwon T: MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells. Cancer Gene Ther. 26:292–304. 2019. View Article : Google Scholar : | |
|
Kong L, Wu Q, Zhao L, Ye J, Li N and Yang H: Upregulated lncRNA-UCA1 contributes to metastasis of bile duct carcinoma through regulation of miR-122/CLIC1 and activation of the ERK/MAPK signaling pathway. Cell Cycle. 18:1212–1228. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Li Q and Guo L: MicroRNA-122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in vitro. Mol Med Rep. 17:8244–8252. 2018.PubMed/NCBI | |
|
Liao B, Wang Z, Zhu Y, Wang M and Liu Y: Long noncoding RNA DRAIC acts as a microRNA-122 sponge to facilitate nasopharyngeal carcinoma cell proliferation, migration and invasion via regulating SATB1. Artif Cells Nanomed Biotechnol. 47:3585–3597. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Liu H, Hou T, Ju W, Xing Y, Zhang X and Yang J: MicroRNA-122 downregulates Rho-associated protein kinase 2 expression and inhibits the proliferation of prostate carcinoma cells. Mol Med Rep. 19:3882–3888. 2019.PubMed/NCBI | |
|
Perez-Añorve IX, Gonzalez-De la Rosa CH, Soto-Reyes E, Beltran-Anaya FO, Del Moral-Hernandez O, Salgado-Albarran M, Angeles-Zaragoza O, Gonzalez-Barrios JA, Landero-Huerta DA and Chavez-Saldaña M: New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR. Mol Oncol. 13:1249–1267. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y and Tang L: Inhibition of breast cancer cell proliferation and tumorigenesis by long non-coding RNA RPPH1 down-regulation of miR-122 expression. Cancer Cell Int. 17:1092017. View Article : Google Scholar : PubMed/NCBI | |
|
Li XN, Yang H and Yang T: miR-122 inhibits hepatocarcinoma cell progression by targeting LMNB2. Oncol Res. 28:41–49. 2020. View Article : Google Scholar | |
|
Iino I, Kikuchi H, Miyazaki S, Hiramatsu Y, Ohta M, Kamiya K, Kusama Y, Baba S, Setou M and Konno H: Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis. Cancer Sci. 104:624–630. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Hua Y, Zhu Y, Zhang J, Zhu Z, Ning Z, Chen H, Liu L, Chen Z and Meng Z: miR-122 targets X-linked inhibitor of apoptosis protein to sensitize oxaliplatin-resistant colorectal cancer cells to oxaliplatin-mediated cytotoxicit. Cell Physiol Biochem. 51:2148–2159. 2018. View Article : Google Scholar | |
|
Wang J, Yu PY, Yu JP, Luo JD, Sun ZQ, Sun F, Kong Z and Wang JL: KIF22 promotes progress of esophageal squamous cell carcinoma cells and is negatively regulated by miR-122. Am J Transl Res. 13:4152–4166. 2021.PubMed/NCBI | |
|
Ding CQ, Deng WS, Yin XF and Ding XD: MiR-122 inhibits cell proliferation and induces apoptosis by targeting runt-related transcription factors 2 in human glioma. Eur Rev Med Pharmacol Sci. 22:4925–4933. 2018.PubMed/NCBI | |
|
Chen C, Deng L, Nie DK, Jia F, Fu LS, Wan ZQ and Lan Q: Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis. Eur J Cancer Prev. 29:165–173. 2020. View Article : Google Scholar | |
|
Fan Y, Ma X, Li H, Gao Y, Huang Q, Zhang Y, Bao X, Du Q, Luo G, Liu K, et al: miR-122 promotes metastasis of clear-cell renal cell carcinoma by downregulating Dicer. Int J Cancer. 142:547–560. 2018. View Article : Google Scholar | |
|
Nie W, Ni D, Ma X, Zhang Y, Gao Y, Peng C and Zhang X: miR-122 promotes proliferation and invasion of clear cell renal cell carcinoma by suppressing Forkhead box O3. Int J Oncol. 54:559–571. 2019. | |
|
Ma J, Wu Q, Zhang Y, Li J, Yu Y, Pan Q and Sun F: MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells. Oncol Rep. 32:2744–2752. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Liu Y, Liu W, Li C, Liu Y, Hu W and Song H: miR-122 inhibits the cervical cancer development by targeting the oncogene RAD21. Biochem Genet. 60:303–314. 2022. View Article : Google Scholar | |
|
Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, et al: Nasopharyngeal carcinoma: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up†. Ann Oncol. 32:452–465. 2021. View Article : Google Scholar | |
|
Chelakkot C, Chelakkot VS, Shin Y and Song K: Modulating glycolysis to improve cancer therapy. Int J Mol Sci. 24:26062023. View Article : Google Scholar : PubMed/NCBI | |
|
Li TE, Wang S, Shen XT, Zhang Z, Chen M, Wang H, Zhu Y, Xu D, Hu BY, Wei R, et al: PKM2 drives hepatocellular carcinoma progression by inducing immunosuppressive microenvironment. Front Immunol. 11:5899972020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu Z, Tang G and Yan J: MicroRNA-122 regulates docetaxel resistance of prostate cancer cells by regulating PKM2. Exp Ther Med. 20:2472020. View Article : Google Scholar : PubMed/NCBI | |
|
Gong H, Zhou L, Khelfat L, Qiu G, Wang Y, Mao K and Chen W: Rho-associated protein kinase (ROCK) promotes proliferation and migration of PC-3 and DU145 prostate cancer cells by targeting LIM kinase 1 (LIMK1) and matrix metalloproteinase-2 (MMP-2). Med Sci Monit. 25:3090–3099. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Yin L, Xu H, Rong J, Feng M, Jiang D and Bai Y: Knockdown of RhoA expression reverts enzalutamide resistance via the P38 MAPK pathway in castration-resistant prostate cancer. Recent Pat Anticancer Drug Discov. 18:92–99. 2023. View Article : Google Scholar | |
|
Sato K, Glaser S, Alvaro D, Meng F, Francis H and Alpini G: Cholangiocarcinoma: Novel therapeutic targets. Expert Opin Ther Targets. 24:345–357. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu N, Jiang F, He TL, Zhang JK, Zhao J, Wang C, Jiang GX, Cao LP, Kang PC, Zhong XY, et al: The roles of MicroRNA-122 overexpression in inhibiting proliferation and invasion and stimulating apoptosis of human cholangiocarcinoma cells. Sci Rep. 5:165662015. View Article : Google Scholar : PubMed/NCBI | |
|
Wu C, Zhang J, Cao X, Yang Q and Xia D: Effect of Mir-122 on human cholangiocarcinoma proliferation, invasion, and apoptosis through P53 expression. Med Sci Monit. 22:2685–2690. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Haibe Y, Kreidieh M, El Hajj H, Khalifeh I, Mukherji D, Temraz S and Shamseddine A: Resistance mechanisms to anti-angiogenic therapies in cancer. Front Oncol. 10:2212020. View Article : Google Scholar : PubMed/NCBI | |
|
Wilkinson L and Gathani T: Understanding breast cancer as a global health concern. Br J Radiol. 95:202110332022. View Article : Google Scholar : | |
|
Anwanwan D, Singh SK, Singh S, Saikam V and Singh R: Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 1873:1883142020. View Article : Google Scholar : | |
|
Wang SC, Lin XL, Li J, Zhang TT, Wang HY, Shi JW, Yang S, Zhao WT, Xie RY, Wei F, et al: MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA. PloS One. 9:e1013302014. View Article : Google Scholar : PubMed/NCBI | |
|
Yahya SMM, Fathy SA, El-Khayat ZA, El-Toukhy SE, Hamed AR, Hegazy MGA and Nabih HK: Possible role of microRNA-122 in Modulating multidrug resistance of hepatocellular carcinoma. Indian J Clin Biochem. 33:21–30. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Duncan AW: Hepatocyte ploidy modulation in liver cancer. EMBO Rep. 21:e519222020. View Article : Google Scholar : PubMed/NCBI | |
|
Hsu SH, Delgado ER, Otero PA, Teng KY, Kutay H, Meehan KM, Moroney JB, Monga JK, Hand NJ, Friedman JR, et al: MicroRNA-122 regulates polyploidization in the murine liver. Hepatology. 64:599–615. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Matsumoto T, Wakefield L, Peters A, Peto M, Spellman P and Grompe M: Proliferative polyploid cells give rise to tumors via ploidy reduction. Nat Commun. 12:6462021. View Article : Google Scholar : PubMed/NCBI | |
|
Matsumoto T: Implications of polyploidy and ploidy alterations in hepatocytes in liver injuries and cancers. Int J Mol Sci. 23:94092022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang F, Long J, Li L, Wu ZX, Da TT, Wang XQ, Huang C, Jiang YH, Yao XQ, Ma HQ, et al: Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer. Sci Adv. 9:eadf54642023. View Article : Google Scholar : PubMed/NCBI | |
|
Huang FL and Yu SJ: Esophageal cancer: Risk factors, genetic association, and treatment. Asian J Surg. 41:210–215. 2018. View Article : Google Scholar | |
|
Zhou K, Yan Y and Zhao S: Esophageal cancer-selective expression of TRAIL mediated by MREs of miR-143 and miR-122. Tumour Biology: Tumour Biol. 35:5787–5795. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Samarakkody AS, Shin NY and Cantor AB: Role of RUNX family transcription factors in DNA damage response. Mol Cells. 43:99–106. 2020.PubMed/NCBI | |
|
DiNardo CD, Erba HP, Freeman SD and Wei AH: Acute myeloid leukaemia. Lancet. 401:2073–2086. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang TJ, Qian Z, Wen XM, Zhou JD, Li XX, Xu ZJ, Ma JC, Zhang ZH, Lin J and Qian J: Lower expression of bone marrow miR-122 is an independent risk factor for overall survival in cytogenetically normal acute myeloid leukemia. Pathol Res Pract. 214:896–901. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Yuan Y, Yang X, Hong Z and Yang L: Decreased expression of microRNA-122 is associated with an unfavorable prognosis in childhood acute myeloid leukemia and function analysis indicates a therapeutic potential. Pathol Res Pract. 213:1166–1172. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Wang C, Xia M, Tian Z, Zhou J, Berger JM, Zhang XH and Xiao H: Engineering small-molecule and protein drugs for targeting bone tumors. Mol Ther. 32:1219–1237. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Liu B, Yao S and Zhou J: Micro-RNA 122 and micro-RNA 96 affected human osteosarcoma biological behavior and associated with prognosis of patients with osteosarcoma. Biosci Rep. 40:BSR202015292020. View Article : Google Scholar : PubMed/NCBI | |
|
Sun L, Liu X, Pan B, Hu X, Zhu Y, Su Y, Guo Z, Zhang G, Xu M, Xu X, et al: Serum exosomal miR-122 as a potential diagnostic and prognostic biomarker of colorectal cancer with liver metastasis. J Cancer. 11:630–637. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Y, Zhao S, Wang J, Li D, Ren Q and Tang Y: Plasma miR-122 as a potential diagnostic and prognostic indicator in human glioma. Neurol Sci. 38:1087–1092. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan G, Jiang H, Yang R and Yang K: miR-122 and miR-197 expressions in hepatic carcinoma patients before and after chemotherapy and their effect on patient prognosis. Am J Transl Res. 13:6731–6737. 2021.PubMed/NCBI | |
|
Cochetti G, Cari L, Nocentini G, Maulà V, Suvieri C, Cagnani R, Rossi De Vermandois JA and Mearini E: Detection of urinary miRNAs for diagnosis of clear cell renal cell carcinoma. Sci Rep. 10:212902020. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Q, Ge X, Zhang Y, Xia H, Yuan D, Tang Q, Chen L, Pang X, Leng W and Bi F: Plasma miR-122 and miR-192 as potential novel biomarkers for the early detection of distant metastasis of gastric cancer. Oncol Rep. 31:1863–1870. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Nakamura K, Hiyake N, Hamada T, Yokoyama S, Mori K, Yamashiro K, Beppu M, Sagara Y, Sagara Y and Sugiura T: Circulating microRNA panel as a potential novel biomarker for oral squamous cell carcinoma diagnosis. Cancers (Basel). 13:4492021. View Article : Google Scholar : PubMed/NCBI | |
|
Maierthaler M, Benner A, Hoffmeister M, Surowy H, Jansen L, Knebel P, Chang-Claude J, Brenner H and Burwinkel B: Plasma miR-122 and miR-200 family are prognostic markers in colorectal cancer. Int J Cancer. 140:176–187. 2017. View Article : Google Scholar | |
|
Deng P, Li M and Wu Y: The predictive efficacy of serum exosomal microRNA-122 and microRNA-148a for hepatocellular carcinoma based on smart healthcare. J Healthc Eng. 2022:59145412022. View Article : Google Scholar : PubMed/NCBI | |
|
Ha SY, Yu JI, Choi C, Kang SY, Joh JW, Paik SW, Kim S, Kim M, Park HC and Park CK: Prognostic significance of miR-122 expression after curative resection in patients with hepatocellular carcinoma. Sci Rep. 9:147382019. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SS, Nam JS, Cho HJ, Won JH, Kim JW, Ji JH, Yang MJ, Park JH, Noh CK, Shin SJ, et al: Plasma micoRNA-122 as a predictive marker for treatment response following transarterial chemoembolization in patients with hepatocellular carcinoma. J Gastroenterol Hepatol. 32:199–207. 2017. View Article : Google Scholar | |
|
Wang S, Liu Y, Feng Y, Zhang J, Swinnen J, Li Y and Ni Y: A review on curability of cancers: More efforts for novel therapeutic options are needed. Cancers (Basel). 11:17822019. View Article : Google Scholar : PubMed/NCBI | |
|
He J, Xie G, Tong J, Peng Y, Huang H, Li J, Wang N and Liang H: Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo. Cell Biochem Biophys. 70:1343–1350. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Dai J, Hao Y, Chen X, Yu Q and Wang B: miR-122/SENP1 axis confers stemness and chemoresistance to liver cancer through Wnt/β-catenin signaling. Oncol Lett. 26:3902023. View Article : Google Scholar | |
|
Cao F and Yin LX: miR-122 enhances sensitivity of hepatocellular carcinoma to oxaliplatin via inhibiting MDR1 by targeting Wnt/β-catenin pathway. Exp Mol Pathol. 106:34–43. 2019. View Article : Google Scholar | |
|
Ma D, Jia H, Qin M, Dai W, Wang T, Liang E, Dong G, Wang Z, Zhang Z and Feng F: MiR-122 induces radiosensitization in non-small cell lung cancer cell line. Int J Mol Sci. 16:22137–22150. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xu G, Bu S, Wang X and Ge H: MiR-122 radiosensitize hepatocellular carcinoma cells by suppressing cyclin G1. Int J Radiat Biol. 98:11–17. 2022. View Article : Google Scholar | |
|
Zhao ZL, Liu C, Wang QZ, Wu HW and Zheng JW: Engineered exosomes for targeted delivery of miR-187-3p suppress the viability of hemangioma stem cells by targeting notch signaling. Ann Transl Med. 10:6212022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Zhou W, Lin L, Chen A, Feng J, Qu X, Zhang H and Yue J: Delivery of therapeutic oligonucleotides in nanoscale. Bioact Mater. 7:292–323. 2021.PubMed/NCBI | |
|
Liang Y, Xu X, Li X, Xiong J, Li B, Duan L, Wang D and Xia J: Chondrocyte-targeted MicroRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy. ACS Appl Mater Interfaces. 12:36938–36947. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Lou G, Song X, Yang F, Wu S, Wang J, Chen Z and Liu Y: Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma. J Hematol Oncol. 8:1222015. View Article : Google Scholar : PubMed/NCBI | |
|
Sweef O, Zaabout E, Bakheet A, Halawa M, Gad I, Akela M, Tousson E, Abdelghany A and Furuta S: Unraveling therapeutic opportunities and the diagnostic potential of microRNAs for human lung cancer. Pharmaceutics. 15:20612023. View Article : Google Scholar : PubMed/NCBI | |
|
Li X, Le Y, Zhang Z, Nian X, Liu B and Yang X: Viral vector-based gene therapy. Int J Mol Sci. 24:77362023. View Article : Google Scholar : PubMed/NCBI | |
|
Yin L, Keeler GD, Zhang Y, Hoffman BE, Ling C, Qing K and Srivastava A: AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo. Gene Ther. 28:422–434. 2021. View Article : Google Scholar : | |
|
Xiao F, Chen J, Lian C, Han P and Zhang C: Tumor necrosis factor-related apoptosis-inducing ligand induces cytotoxicity specific to osteosarcoma by microRNA response elements. Mol Med Rep. 11:739–745. 2015. View Article : Google Scholar | |
|
Zhang J, Li D, Zhang R, Peng R and Li J: Delivery of microRNA-21-sponge and pre-microRNA-122 by MS2 virus-like particles to therapeutically target hepatocellular carcinoma cells. Exp Biol Med (Maywood). 246:2463–2472. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Shui M, Chen Z, Chen Y, Yuan Q, Li H, Vong CT, Farag MA and Wang S: Engineering polyphenol-based carriers for nucleic acid delivery. Theranostics. 13:3204–3223. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Yan Y, Liu XY, Lu A, Wang XY, Jiang LX and Wang JC: Non-viral vectors for RNA delivery. J Control Release. 342:241–279. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, et al: Nanoparticle delivery of miR-122 inhibits colorectal cancer liver metastasis. Cancer Res. 82:105–113. 2022. View Article : Google Scholar : | |
|
Guo H, Xu M, Cao Z, Li W, Chen L, Xie X, Wang W and Liu J: Ultrasound-assisted miR-122-loaded polymeric nanodroplets for hepatocellular carcinoma gene therapy. Mol Pharm. 17:541–553. 2020. | |
|
Zeng X, Yuan Y, Wang T, Wang H, Hu X, Fu Z, Zhang G, Liu B and Lu G: Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds. J Nanobiotechnology. 15:92017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang HT, Sun J, Yan Y, Cui SH, Wang H, Wang CH, Qiu C, Chen X, Ding JS, Qian HG, et al: Encapsulated microRNA by gemcitabine prodrug for cancer treatment. J Control Release. 316:317–330. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Z, Xu Z, Zhu X and Zhang J: New insights into molecules and pathways of cancer metabolism and therapeutic implications. Cancer Commun (Lond). 41:16–36. 2021. View Article : Google Scholar | |
|
Novikov NM, Zolotaryova SY, Gautreau AM and Denisov EV: Mutational drivers of cancer cell migration and invasion. Br J Cancer. 124:102–114. 2021. View Article : Google Scholar : | |
|
Hsu KH, Wei CW, Su YR, Chou T, Lin YL, Yang FC, Tsou AP, Hsu CL, Tseng PH, Chen NJ, et al: Upregulation of RelB in the miR-122 knockout mice contributes to increased levels of proinflammatory chemokines/cytokines in the liver and macrophages. Immunol Lett. 226:22–30. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Nabih HK: The significance of HCV viral load in the incidence of HCC: A correlation between Mir-122 and CCL2. J Gastrointest Cancer. 51:412–417. 2020. View Article : Google Scholar |
