Open Access

Molecular mechanisms and targeted therapy for the metastasis of prostate cancer to the bones (Review)

  • Authors:
    • Yankai Xu
    • Gang Zhang
    • Yuanyuan Liu
    • Yangyang Liu
    • Aimin Tian
    • Jizhong Che
    • Zhengchao Zhang
  • View Affiliations

  • Published online on: September 12, 2024     https://doi.org/10.3892/ijo.2024.5692
  • Article Number: 104
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

The incidence of prostate cancer (PCa) is increasing, making it one of the prevalent malignancies among men. Metastasis of PCa to the bones poses the greatest danger to patients, potentially resulting in treatment ineffectiveness and mortality. At present, the management of patients with bone metastasis focuses primarily on providing palliative care. Research has indicated that the spread of PCa to the bones occurs through the participation of numerous molecules and their respective pathways. Gaining knowledge regarding the molecular processes involved in bone metastasis may result in the development of innovative and well‑tolerated therapies, ultimately enhancing the quality of life and prognosis of patients. The present article provides the latest overview of the molecular mechanisms involved in the formation of bone metastatic tumors from PCa. Additionally, the clinical outcomes of targeted drug therapies for bone metastasis are thoroughly analyzed. Finally, the benefits and difficulties of targeted therapy for bone metastasis of PCa are discussed, aiming to offer fresh perspectives for treatment.
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November-2024
Volume 65 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Xu Y, Zhang G, Liu Y, Liu Y, Tian A, Che J and Zhang Z: Molecular mechanisms and targeted therapy for the metastasis of prostate cancer to the bones (Review). Int J Oncol 65: 104, 2024.
APA
Xu, Y., Zhang, G., Liu, Y., Liu, Y., Tian, A., Che, J., & Zhang, Z. (2024). Molecular mechanisms and targeted therapy for the metastasis of prostate cancer to the bones (Review). International Journal of Oncology, 65, 104. https://doi.org/10.3892/ijo.2024.5692
MLA
Xu, Y., Zhang, G., Liu, Y., Liu, Y., Tian, A., Che, J., Zhang, Z."Molecular mechanisms and targeted therapy for the metastasis of prostate cancer to the bones (Review)". International Journal of Oncology 65.5 (2024): 104.
Chicago
Xu, Y., Zhang, G., Liu, Y., Liu, Y., Tian, A., Che, J., Zhang, Z."Molecular mechanisms and targeted therapy for the metastasis of prostate cancer to the bones (Review)". International Journal of Oncology 65, no. 5 (2024): 104. https://doi.org/10.3892/ijo.2024.5692