Open Access

Pathogenetic development, diagnosis and clinical therapeutic approaches for liver metastasis from colorectal cancer (Review)

  • Authors:
    • Zhenhua Jin
    • Yin Li
    • Hao Yi
    • Menghui Wang
    • Chaofeng Wang
    • Shaokun Du
    • Wenjuan Zeng
    • Zhen Zong
  • View Affiliations

  • Published online on: February 14, 2025     https://doi.org/10.3892/ijo.2025.5728
  • Article Number: 22
  • Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is a prevalent malignancy and a significant proportion of patients with CRC develop liver metastasis (CRLM), which is a major contributor to CRC‑related mortality. The present review aimed to comprehensively examine the pathogenetic development and diagnosis of CRLM and the clinical therapeutic approaches for treatment of this disease. The molecular mechanisms underlying CRLM were discussed, including the role of the tumour microenvironment and epithelial‑mesenchymal transition. The present review also highlighted the importance of early detection and the current challenges in predicting the development of CRLM. Various treatment strategies were reviewed, including surgical resection, chemotherapy and immunotherapy, and the potential of novel therapies, such as selective internal radiation therapy and Traditional Chinese Medicine. Despite recent advancements in treatment options, the treatment of CRLM remains a therapeutic challenge due to the complexity of the liver microenvironment and the heterogeneity of CRC. The present review emphasized the need for a multidisciplinary approach and the integration of emerging therapies to improve patient outcomes.
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March-2025
Volume 66 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Jin Z, Li Y, Yi H, Wang M, Wang C, Du S, Zeng W and Zong Z: Pathogenetic development, diagnosis and clinical therapeutic approaches for liver metastasis from colorectal cancer (Review). Int J Oncol 66: 22, 2025.
APA
Jin, Z., Li, Y., Yi, H., Wang, M., Wang, C., Du, S. ... Zong, Z. (2025). Pathogenetic development, diagnosis and clinical therapeutic approaches for liver metastasis from colorectal cancer (Review). International Journal of Oncology, 66, 22. https://doi.org/10.3892/ijo.2025.5728
MLA
Jin, Z., Li, Y., Yi, H., Wang, M., Wang, C., Du, S., Zeng, W., Zong, Z."Pathogenetic development, diagnosis and clinical therapeutic approaches for liver metastasis from colorectal cancer (Review)". International Journal of Oncology 66.3 (2025): 22.
Chicago
Jin, Z., Li, Y., Yi, H., Wang, M., Wang, C., Du, S., Zeng, W., Zong, Z."Pathogenetic development, diagnosis and clinical therapeutic approaches for liver metastasis from colorectal cancer (Review)". International Journal of Oncology 66, no. 3 (2025): 22. https://doi.org/10.3892/ijo.2025.5728