Effects of a high virgin olive oil diet on the promotion stage of dimethylbenz(α)anthracene-induced mammary carcinogenesis in rats were investigated in comparison with those of a high corn oil diet. Animals were randomly placed into 4 groups: control, fed a normolipidic control diet (3% corn oil); M, fed a high corn oil diet (20%); O, fed a high olive oil diet (3% corn oil plus 17% olive oil); and MO, fed the high olive oil diet after 33 days of high corn oil diet. Whereas the high corn oil diet clearly stimulated the mammary carcinogenesis, reducing the latency time and increasing the tumor incidence, multiplicity and volume, the high olive oil diet led to a lower tumor incidence than in the former group, a latency time similar to that of the control and lower tumor multiplicity and volume even than in the control group. Moreover, the histopathological features of the adenocarcinomas in olive oil groups were compatible with a greater degree of differentiation. These data suggest that the high virgin olive oil diet would have acted as a negative modulator of the experimental mammary carcinogenesis conferring to the tumors a more benign clinical behavior and a lower histopathological malignancy in comparison with the control and high corn oil diets.

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