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Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome

  • Authors:
    • Frédérique Penault-Llorca
    • Anne Cayre
    • Florence Bouchet Mishellany
    • Sophie Amat
    • Viviane Feillel
    • Guillaume Le Bouedec
    • Jean-Pierre Ferrière
    • Monique De Latour
    • Philippe Chollet

  • View Affiliations

  • Published online on: June 1, 2003     https://doi.org/10.3892/ijo.22.6.1319
  • Pages: 1319-1325
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Induction chemotherapy provides an excellent model for evaluation of potential predictive factors. We studied expression of SBR grade, estrogen (ER) and progesterone (PR) receptors, HER2, Ki67 and P53 on core biopsies before and after chemotherapy in a series of 115 patients, who received anthracycline-based induction chemotherapy for primary breast cancer. HER2 overexpression independently predicted response to neoadjuvant anthracycline-based chemotherapy. Patients with HER2-positive status are 4.54 times more likely to have a pathological complete response than those with negative status (p<0.005). HER2, ER and PR status were stable during treatment. P53 and Ki67 significantly increased after treatment (p<0.005 and p<0.0005). SBR grade, proliferation markers, ER evaluated before and after treatment predicted disease-free survival (DFS) in univariate analysis.

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Journal Cover

June 2003
Volume 22 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Penault-Llorca F, Cayre A, Bouchet Mishellany F, Amat S, Feillel V, Le Bouedec G, Ferrière J, De Latour M and Chollet P: Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome. Int J Oncol 22: 1319-1325, 2003.
APA
Penault-Llorca, F., Cayre, A., Bouchet Mishellany, F., Amat, S., Feillel, V., Le Bouedec, G. ... Chollet, P. (2003). Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome. International Journal of Oncology, 22, 1319-1325. https://doi.org/10.3892/ijo.22.6.1319
MLA
Penault-Llorca, F., Cayre, A., Bouchet Mishellany, F., Amat, S., Feillel, V., Le Bouedec, G., Ferrière, J., De Latour, M., Chollet, P."Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome". International Journal of Oncology 22.6 (2003): 1319-1325.
Chicago
Penault-Llorca, F., Cayre, A., Bouchet Mishellany, F., Amat, S., Feillel, V., Le Bouedec, G., Ferrière, J., De Latour, M., Chollet, P."Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome". International Journal of Oncology 22, no. 6 (2003): 1319-1325. https://doi.org/10.3892/ijo.22.6.1319