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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1993 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1993 Volume 3 Issue 4

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Article

IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA

  • Authors:
    • EM SOTOMAYOR
    • XF CHENG
    • YX FU
    • A HAWKINS
    • C CALDERON-HIGGINSON
    • DM LOPEZ

  • View Affiliations / Copyright

    Affiliations: UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,POB 016960 R-138,MIAMI,FL 33101. SYLVESTER COMPREHENS CANC CTR,MIAMI,FL 33136.
  • Pages: 719-727
    |
    Published online on: October 1, 1993
       https://doi.org/10.3892/ijo.3.4.719
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Abstract

The growth of the DI-DMBA-3 mammary adenocarcinoma in BALB/c mice results in a profound deficit in the tumoricidal function of their peritoneal elicited macrophages (PEM) after stimulation with lipopolysaccharide (LPS). The capacity of these macrophages to respond to stronger signals, such as a combination of LPS and low levels (5 U/ml) of interferon-gamma (IFN-gamma) is also impaired. Importantly, a combination of high levels (50 U/ml) of IFN-gamma with 10 mug/ml of LPS, is able to trigger a cytolytic response in macrophages from tumor bearing mice against mammary tumor target cells, indicating that their lytic machinery is intact. However, IFN-gamma production is severely diminished in T lymphocytes from tumor bearing mice as detected by ELISA, moreover, Northern blots revealed that the levels of IFN-gamma RNA are also decreased in T cells from tumor bearers. The cooperation between T cells and macrophages is mediated, at least in part, by IFN-gamma. Thus, mammary tumors have die potential to overcome host defenses, either by affecting the capacity of macrophages to respond adequately to activating agents, and/or by impairing the production of T-cell derived lymphokines important in macrophage activation for tumor killing.

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Copy and paste a formatted citation
Spandidos Publications style
SOTOMAYOR E, CHENG X, FU Y, HAWKINS A, CALDERON-HIGGINSON C and LOPEZ D: IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA. Int J Oncol 3: 719-727, 1993.
APA
SOTOMAYOR, E., CHENG, X., FU, Y., HAWKINS, A., CALDERON-HIGGINSON, C., & LOPEZ, D. (1993). IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA. International Journal of Oncology, 3, 719-727. https://doi.org/10.3892/ijo.3.4.719
MLA
SOTOMAYOR, E., CHENG, X., FU, Y., HAWKINS, A., CALDERON-HIGGINSON, C., LOPEZ, D."IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA". International Journal of Oncology 3.4 (1993): 719-727.
Chicago
SOTOMAYOR, E., CHENG, X., FU, Y., HAWKINS, A., CALDERON-HIGGINSON, C., LOPEZ, D."IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA". International Journal of Oncology 3, no. 4 (1993): 719-727. https://doi.org/10.3892/ijo.3.4.719
Copy and paste a formatted citation
x
Spandidos Publications style
SOTOMAYOR E, CHENG X, FU Y, HAWKINS A, CALDERON-HIGGINSON C and LOPEZ D: IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA. Int J Oncol 3: 719-727, 1993.
APA
SOTOMAYOR, E., CHENG, X., FU, Y., HAWKINS, A., CALDERON-HIGGINSON, C., & LOPEZ, D. (1993). IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA. International Journal of Oncology, 3, 719-727. https://doi.org/10.3892/ijo.3.4.719
MLA
SOTOMAYOR, E., CHENG, X., FU, Y., HAWKINS, A., CALDERON-HIGGINSON, C., LOPEZ, D."IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA". International Journal of Oncology 3.4 (1993): 719-727.
Chicago
SOTOMAYOR, E., CHENG, X., FU, Y., HAWKINS, A., CALDERON-HIGGINSON, C., LOPEZ, D."IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA". International Journal of Oncology 3, no. 4 (1993): 719-727. https://doi.org/10.3892/ijo.3.4.719
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