search button

Advanced glycation end product (AGE)-induced proliferation of HEL cells via receptor for AGE-related signal pathways

  • Authors:
    • Ju Young Kim
    • Hyun Ki Park
    • Jin Sun Yoon
    • Seo Ju Kim
    • Eun Shil Kim
    • Kwang Sung Ahn
    • Dong-Sun Kim
    • Sung Soo Yoon
    • Byoung Kook Kim
    • Young Yiul Lee

  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/ijo_00000032
  • Pages: 493-501
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

This study investigated whether advanced glycation end products (AGE) and RAGE (receptor for AGE) are involved in the proliferation of leukemia cells. AGE strongly induced the proliferation of primary acute myeloid leukemia (AML) cells and cell lines. MAP kinase, PI3K and JAK/STAT pathways were involved in cellular proliferation of HEL cells by AGE. RAGE antisense S-ODN effectively inhibited cell growth, induced apoptosis and reversed AGE-induced expression of targeting molecules in HEL cells. The study demonstrated for the first time that AGE directly induced human AML cell proliferation via the MAPK, PI3K and JAK/STAT pathways.

Related Articles

Journal Cover

September 2008
Volume 33 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Kim JY, Park HK, Yoon JS, Kim SJ, Kim ES, Ahn KS, Kim D, Yoon SS, Kim BK, Lee YY, Lee YY, et al: Advanced glycation end product (AGE)-induced proliferation of HEL cells via receptor for AGE-related signal pathways. Int J Oncol 33: 493-501, 2008.
APA
Kim, J.Y., Park, H.K., Yoon, J.S., Kim, S.J., Kim, E.S., Ahn, K.S. ... Lee, Y.Y. (2008). Advanced glycation end product (AGE)-induced proliferation of HEL cells via receptor for AGE-related signal pathways. International Journal of Oncology, 33, 493-501. https://doi.org/10.3892/ijo_00000032
MLA
Kim, J. Y., Park, H. K., Yoon, J. S., Kim, S. J., Kim, E. S., Ahn, K. S., Kim, D., Yoon, S. S., Kim, B. K., Lee, Y. Y."Advanced glycation end product (AGE)-induced proliferation of HEL cells via receptor for AGE-related signal pathways". International Journal of Oncology 33.3 (2008): 493-501.
Chicago
Kim, J. Y., Park, H. K., Yoon, J. S., Kim, S. J., Kim, E. S., Ahn, K. S., Kim, D., Yoon, S. S., Kim, B. K., Lee, Y. Y."Advanced glycation end product (AGE)-induced proliferation of HEL cells via receptor for AGE-related signal pathways". International Journal of Oncology 33, no. 3 (2008): 493-501. https://doi.org/10.3892/ijo_00000032