Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

  • Authors:
    • Sergio Salerno
    • Maria Chiara Terranova
    • Mario Rossello
    • Maria Piccione
    • Ottavio Ziino
    • Giuseppe Lo Re
  • View Affiliations

  • Published online on: Friday, February 17, 2017
  • Pages:579-582 DOI: 10.3892/mco.2017.1171
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Abstract

Myofibromatosis is an uncommon disorder of infancy, characterized by proliferation of myofibroblasts in solitary or multiple nodules. The clinical characteristics depend on the involved sites: Myofibromatosis may develop as a musculoskeletal form, with non-painful swellings and eventual mass effect symptoms, or as a generalized form with visceral involvement and organ failure. Prognosis and therapy vary between the abovementioned patterns. When there is no visceral involvement, the tumors may regress spontaneously; however, the visceral form may represent a lifethreatening condition with poor outcome and it requires aggressive management. Imaging assessment of disease spread is mandatory to determine diagnosis, prognosis and therapy. Due to the young age of the patients, a radiation-free evaluation is recommended. We herein describe a case of musculoskeletal myofibromatosis diagnosed in a 3-month-old male infant, investigated by serial wholebody magnetic resonance imaging (MRI) examination. The histological analysis and MRI characteristics enabled a correct diagnosis and organ involvement assessment with no radiation exposure. Moreover, whole-body MRI sequences provided a detailed evaluation of the disease within a short time frame, reducing the time of sedation, which is required to perform MRI in very young patients. Therefore, whole-body MRI was found to be accurate and safe in the diagnosis and follow-up of multicentric infantile myofibromatosis.

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April 2017
Volume 6 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Salerno, S., Terranova, M.C., Rossello, M., Piccione, M., Ziino, O., & Re, G.L. (2017). Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report. Molecular and Clinical Oncology, 6, 579-582. http://dx.doi.org/10.3892/mco.2017.1171
MLA
Salerno, S., Terranova, M. C., Rossello, M., Piccione, M., Ziino, O., Re, G. L."Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report". Molecular and Clinical Oncology 6.4 (2017): 579-582.
Chicago
Salerno, S., Terranova, M. C., Rossello, M., Piccione, M., Ziino, O., Re, G. L."Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report". Molecular and Clinical Oncology 6, no. 4 (2017): 579-582. http://dx.doi.org/10.3892/mco.2017.1171