Open Access

Ameloblastic fibro‑odontosarcoma of the mandible with active epithelial proliferation: A rare case report

  • Authors:
    • Haoman Niu
    • Junyu Liu
    • Yu Chen
    • Ning Geng
  • View Affiliations

  • Published online on: October 12, 2017     https://doi.org/10.3892/mco.2017.1448
  • Pages:971-975
  • Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ameloblastic fibro‑odontosarcoma (AFOS) is an extremely rare subtype of odontogenic sarcoma, with no more than 19 cases reported in the English literature to date. AFOS is a biphasic neoplasm, with deposits of dentin and enamel matrix. We herein present a case of AFOS with active epithelial proliferation in a 31‑year‑old female patient. The patient was referred to the West China Hospital of Stomatology (Chengdu, China) due to a 6‑month history of a swelling in the left mandible. Following clinical and radiological examination, the initial preoperative diagnosis was ameloblastoma, with local invasion and the possibility of malignant transformation. Left hemimandibular resection was subsequently performed. The postoperative histopathological diagnosis was AFOS, accompanied by active epithelial proliferation. Immunohistochemically, cytokeratin (CK)14 and CK19 were intensely positive in the epithelium, whereas the mesenchymal cells were strongly positive for vimentin. The Ki‑67 labeling index was considerably higher in the mesenchymal component (mean, 40%) compared with that in the epithelial element (mean, 5‑8%). Three months after the surgical procedure, the patient remained clinically and radiologically disease‑free.

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December 2017
Volume 7 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Niu, H., Liu, J., Chen, Y., & Geng, N. (2017). Ameloblastic fibro‑odontosarcoma of the mandible with active epithelial proliferation: A rare case report. Molecular and Clinical Oncology, 7, 971-975. https://doi.org/10.3892/mco.2017.1448
MLA
Niu, H., Liu, J., Chen, Y., Geng, N."Ameloblastic fibro‑odontosarcoma of the mandible with active epithelial proliferation: A rare case report". Molecular and Clinical Oncology 7.6 (2017): 971-975.
Chicago
Niu, H., Liu, J., Chen, Y., Geng, N."Ameloblastic fibro‑odontosarcoma of the mandible with active epithelial proliferation: A rare case report". Molecular and Clinical Oncology 7, no. 6 (2017): 971-975. https://doi.org/10.3892/mco.2017.1448