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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2008 Volume 1 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

A low level of nicotine-induced chemoresistance in a KB cell line

  • Authors:
    • Nam-Yong Do
    • Sung-Chul Lim

  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, College of Medicine, Chosun University, Gwangju 501-759, Korea
  • Pages: 55-60
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/mmr.1.1.55
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Abstract

Cigarette smoking is closely associated with the induction of head and neck squamous cell carcinomas (HNSCC). Nicotine is an important component in cigarette smoke that can activate the growth-promoting pathways and facilitate the development of cancer. As nicotine is currently used in replacement therapy for smoking cessation in different forms, from skin patches to the oral route, numerous studies have investigated the effect of nicotine on the body, but the results have been equivocal. The aim of this study was to investigate the effect of nicotine on cancer chemotherapy. The status of the cell death-related proteins after treatment with nicotine was determined and compared to the effect of anticancer drugs such as cisplatin and etoposide in the presence or absence of nicotine in the KB cell line. Nicotine induced Bad phosphorylation in association with the suppression of apoptosis. The inhibition rate of cells pre-treated with nicotine prior to anticancer drug exposure was significantly decreased when compared to cells exposed to anticancer drugs only (P<0.01). Collectively, this suggests that nicotine may alter chemo-resistance and carcinogenesis via the anti-apoptotic pathway in HNSCC, and chemotherapy for HNSCC should be performed in the absence of nicotine in patient blood.

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Copy and paste a formatted citation
Spandidos Publications style
Do N and Lim S: A low level of nicotine-induced chemoresistance in a KB cell line. Mol Med Rep 1: 55-60, 2008.
APA
Do, N., & Lim, S. (2008). A low level of nicotine-induced chemoresistance in a KB cell line. Molecular Medicine Reports, 1, 55-60. https://doi.org/10.3892/mmr.1.1.55
MLA
Do, N., Lim, S."A low level of nicotine-induced chemoresistance in a KB cell line". Molecular Medicine Reports 1.1 (2008): 55-60.
Chicago
Do, N., Lim, S."A low level of nicotine-induced chemoresistance in a KB cell line". Molecular Medicine Reports 1, no. 1 (2008): 55-60. https://doi.org/10.3892/mmr.1.1.55
Copy and paste a formatted citation
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Spandidos Publications style
Do N and Lim S: A low level of nicotine-induced chemoresistance in a KB cell line. Mol Med Rep 1: 55-60, 2008.
APA
Do, N., & Lim, S. (2008). A low level of nicotine-induced chemoresistance in a KB cell line. Molecular Medicine Reports, 1, 55-60. https://doi.org/10.3892/mmr.1.1.55
MLA
Do, N., Lim, S."A low level of nicotine-induced chemoresistance in a KB cell line". Molecular Medicine Reports 1.1 (2008): 55-60.
Chicago
Do, N., Lim, S."A low level of nicotine-induced chemoresistance in a KB cell line". Molecular Medicine Reports 1, no. 1 (2008): 55-60. https://doi.org/10.3892/mmr.1.1.55
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