Open Access

Effects of ischemic preconditioning on PDGF-BB expression in the gerbil hippocampal CA1 region following transient cerebral ischemia

  • Authors:
    • Jae‑Chul Lee
    • Yang Hee Kim
    • Tae‑Kyeong Lee
    • In Hye Kim
    • Jeong Hwi Cho
    • Geum‑Sil Cho
    • Bich‑Na Shin
    • Joon Ha Park
    • Ji Hyeon Ahn
    • Myoung Cheol Shin
    • Jun Hwi Cho
    • Il Jun Kang
    • Moo‑Ho Won
    • Jeong Yeol Seo
  • View Affiliations

  • Published online on: June 19, 2017     https://doi.org/10.3892/mmr.2017.6799
0

Abstract

Ischemic preconditioning (IPC) is induced by exposure to brief durations of transient ischemia, which results in ischemic tolerance to a subsequent longer or lethal period of ischemia. In the present study, the effects of IPC (2 min of transient cerebral ischemia) were examined on immunoreactivity of platelet‑derived growth factor (PDGF)‑BB and on neuroprotection in the gerbil hippocampal CA1 region following lethal transient cerebral ischemia (LTCI; 5 min of transient cerebral ischemia). IPC was subjected to a 2‑min sublethal ischemia and a LTCI was given 5‑min transient ischemia. The animals in all of the groups were given recovery times of 1, 2 and 5 days and change in PDGF‑BB immunoreactivity was examined as was the neuronal damage/death in the hippocampus induced by LTCI. LTCI induced a significant loss of pyramidal neurons in the hippocampal CA1 region 5 days after LTCI, and significantly decreased PDGF‑BB immunoreactivity in the CA1 pyramidal neurons from day 1 after LTCI. Conversely, IPC effectively protected the CA1 pyramidal neurons from LTCI and increased PDGF‑BB immunoreactivity in the CA1 pyramidal neurons post‑LTCI. In conclusion, the results demonstrated that LTCI significantly altered PDGF‑BB immunoreactivity in pyramidal neurons in the hippocampal CA1 region, whereas IPC increased the immunoreactivity. These findings indicated that PDGF‑BB may be associated with IPC‑mediated neuroprotection.

Related Articles

Journal Cover

Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
Ranked #19/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Lee, J., Kim, Y.H., Lee, T., Kim, I.H., Cho, J.H., Cho, G. ... Seo, J.Y. (1899). Effects of ischemic preconditioning on PDGF-BB expression in the gerbil hippocampal CA1 region following transient cerebral ischemia. Molecular Medicine Reports, 0, 0-0. https://doi.org/10.3892/mmr.2017.6799
MLA
Lee, J., Kim, Y. H., Lee, T., Kim, I. H., Cho, J. H., Cho, G., Shin, B., Park, J. H., Ahn, J. H., Shin, M. C., Cho, J. H., Kang, I. J., Won, M., Seo, J. Y."Effects of ischemic preconditioning on PDGF-BB expression in the gerbil hippocampal CA1 region following transient cerebral ischemia". Molecular Medicine Reports 0.0 (1899): 0-0.
Chicago
Lee, J., Kim, Y. H., Lee, T., Kim, I. H., Cho, J. H., Cho, G., Shin, B., Park, J. H., Ahn, J. H., Shin, M. C., Cho, J. H., Kang, I. J., Won, M., Seo, J. Y."Effects of ischemic preconditioning on PDGF-BB expression in the gerbil hippocampal CA1 region following transient cerebral ischemia". Molecular Medicine Reports 0, no. 0 (1899): 0-0. https://doi.org/10.3892/mmr.2017.6799