Melanoma leptomeningeal dissemination following frontoparietal metastasis surgery: Case report and review of the literature
- Authors:
- María Sereno Moyano
- Gerardo Gutiérrez-Gutiérrez
- Isabel Rodríguez‑Esteban
- Gemma Sánchez Crespo
- Enrique Casado
View Affiliations
Affiliations: Department of Medical Oncology, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain, Department of Neurology, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain, Department of Pathology, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain, Department of Clinical Analysis, Infanta Sofía Hospital, 28702 San Sebastián de los Reyes, Madrid, Spain
- Published online on: September 23, 2010 https://doi.org/10.3892/ol.2010.194
-
Pages:
1101-1104
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Abstract
We present the case of a patient with a solitary left frontoparietal brain metastasis of melanoma previously treated with surgery. Three months later, the patient was admitted to the emergency room in a confusional state with meningeal signs. A cerebrospinal fluid (CSF) test and magnetic resonance imaging findings suggested a subarachnoid haemorrhage (SAH) and/or meningeal carcinomatosis. The results of a cytological examination of the CSF showed neoplastic epithelial cells consistent with metastatic melanoma cells. Resection of metastatic posterior fossa lesions is often cited as a risk factor for leptomeningeal dissemination, however, when the resection is limited to the anterior fossa, this complication is relatively rare. In contrast, SAH may be a complication of leptomeningeal dissemination and responsible for acute meningeal syndrome. Treatment with high doses of corticoids did not show any improvement, and intrathecal chemotherapy was not possible due to the patient's poor functional status. She succumbed 1 week after admission.
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