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A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer

  • Authors:
    • Hideki Tomimoto
    • Masaki Hanibuchi
    • Fumitaka Ogushi
    • Yoshio Okano
    • Tsutomu Shinohara
    • Hiroyuki Doi
    • Akiyoshi Yamamoto
    • Eiji Takeuchi
    • Akihiko Yamamoto
    • Masahiko Azuma
    • Hiroya Tada
    • Takanori Kanematsu
    • Soji  Kakiuchi
    • Hisatsugu Goto
    • Seiji Yano
    • Yasuhiko Nishioka
    • Saburo Sone
  • View Affiliations

  • Published online on: March 10, 2011     https://doi.org/10.3892/ol.2011.266
  • Pages: 465-470
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Abstract

S-1 is an oral anticancer fluoropyrimidine agent designed to elevate anticancer activity with a decrease in gastrointestinal toxicity. We conducted a phase II study to evaluate the efficacy and safety of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer (NSCLC). Chemotherapy-naïve patients were treated with S-1 administered orally at 40 mg/m2 twice a day for 21 consecutive days, and cisplatin (60 mg/m2) infused intravenously on day 8, repeated every 5 weeks. Of the 44 patients enrolled in the study, 40 were assessable for efficacy and safety. The median number of cycles administered was 3 (range 1-9 cycles). Among the 40 assessable patients, 7 partial responses were observed, with an overall response rate (RR) of 17.5% [95% confidence interval (CI), 5.2-29.8]. Patients with squamous cell carcinoma showed a significantly higher RR (55.5%) than those with adenocarcinoma (9.1%) or other types of NSCLC (0%). The median progression-free survival was 4.3 months (95% CI, 3.4-4.9), the median survival time was 17.9 months (95% CI, 15.0-20.8), and the 1- and 2-year survival rates were 63.3 and 27.3%, respectively. Major grade 3-4 hematologic toxicities were leukocytopenia (7.5%), neutropenia (5.0%), anemia (15.0%) and thrombocytopenia (2.5%). No grade 4 non-hematologic toxicity or treatment-related death occurred. These results suggest that combination chemotherapy with S-1 plus cisplatin is a promising therapeutic candidate for patients with advanced NSCLC, particularly squamous cell carcinoma.
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May-June 2011
Volume 2 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tomimoto H, Hanibuchi M, Ogushi F, Okano Y, Shinohara T, Doi H, Yamamoto A, Takeuchi E, Yamamoto A, Azuma M, Azuma M, et al: A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer. Oncol Lett 2: 465-470, 2011.
APA
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H. ... Sone, S. (2011). A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer. Oncology Letters, 2, 465-470. https://doi.org/10.3892/ol.2011.266
MLA
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H., Yamamoto, A., Takeuchi, E., Yamamoto, A., Azuma, M., Tada, H., Kanematsu, T., Kakiuchi, S., Goto, H., Yano, S., Nishioka, Y., Sone, S."A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer". Oncology Letters 2.3 (2011): 465-470.
Chicago
Tomimoto, H., Hanibuchi, M., Ogushi, F., Okano, Y., Shinohara, T., Doi, H., Yamamoto, A., Takeuchi, E., Yamamoto, A., Azuma, M., Tada, H., Kanematsu, T., Kakiuchi, S., Goto, H., Yano, S., Nishioka, Y., Sone, S."A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer". Oncology Letters 2, no. 3 (2011): 465-470. https://doi.org/10.3892/ol.2011.266