Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature

  • Authors:
    • Machiko Hotta
    • Mitsuaki Ishida
    • Fumiyoshi Kojima
    • Yasuhiro Iwai
    • Hidetoshi Okabe
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  • Published online on: March 18, 2011     https://doi.org/10.3892/ol.2011.270
  • Pages: 435-437
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Abstract

Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon cancer-related complication characterized by intimal proliferation in pulmonary small arteries and arterioles with or without tumor emboli. In the majority of cases, the causative lesion is gastric poorly differentiated adenocarcinoma. In the present study, an autopsy case of PTTM caused by lung adenocarcinoma is reported and the pathogenesis of this complication is discussed. Multiple nodular lesions in the bilateral lungs were found in a 62-year-old Japanese man. Transbronchial biopsy revealed non-small cell carcinoma. Chemotherapy was performed; however, the patient succumbed to sudden dyspnea. Autopsy revealed poorly differentiated adenocarcinoma with multiple intrapulmonary metastases and intimal proliferation of pulmonary small arteries and arterioles with or without tumor emboli, which were characteristic of PTTM. Tumor cells were immunohistochemically positive for vascular endothelial growth factor (VEGF) and osteopontin (OPN), which are endothelial proliferative factors. This case indicates the possible involvement of VEGF and OPN in the pathogenesis of PTTM caused by lung adenocarcinoma.
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May-June 2011
Volume 2 Issue 3

Print ISSN: 1792-1074
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Spandidos Publications style
Hotta M, Ishida M, Kojima F, Iwai Y and Okabe H: Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature. Oncol Lett 2: 435-437, 2011.
APA
Hotta, M., Ishida, M., Kojima, F., Iwai, Y., & Okabe, H. (2011). Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature. Oncology Letters, 2, 435-437. https://doi.org/10.3892/ol.2011.270
MLA
Hotta, M., Ishida, M., Kojima, F., Iwai, Y., Okabe, H."Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature". Oncology Letters 2.3 (2011): 435-437.
Chicago
Hotta, M., Ishida, M., Kojima, F., Iwai, Y., Okabe, H."Pulmonary tumor thrombotic microangiopathy caused by lung adenocarcinoma: Case report with review of the literature". Oncology Letters 2, no. 3 (2011): 435-437. https://doi.org/10.3892/ol.2011.270