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Immunophenotype and increased presence of CD4+CD25+ regulatory T cells in patients with acute lymphoblastic leukemia

  • Authors:
    • Cui-Ping Wu
    • Xi Qing
    • Cui-Yun Wu
    • Hong Zhu
    • Hai-Yan Zhou

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  • Published online on: November 29, 2011     https://doi.org/10.3892/ol.2011.499
  • Pages: 421-424
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Abstract

Acute lymphoblastic leukemia (ALL), cancer of the white blood cells, is a heterogeneous disease that mainly occurs due to the malignant cloning of original and naive lymphocytes. The aim of this study was to explore the immunophenotype, the percentage of CD4+CD25+ regulatory T cells (Tregs) and the expression of cytokines interleukin (IL)-2, IL-10 and TGF-β in patients with ALL. The immunophenotype and levels of CD4+CD25+ Tregs were detected using flow cytometry in the peripheral blood of 35 ALL patients, with 18 healthy individuals being selected as controls. The results suggested that 22 patients had B cell ALL (B-ALL) and 13 had T cell ALL (T-ALL) among the 35 ALL patients. In B-ALL patients, the surface antigen CD19 was most commonly expressed; in T-ALL patients, CD7 was most common. Furthermore, the percentage of CD4+CD25+ Treg cells in the peripheral blood of B-ALL and T-ALL patients was higher compared to that of healthy individuals (P<0.05). Additionally, IL-10 and TGF-β levels in cell culture supernatants from B-ALL and T-ALL patients were higher compared to those in the controls (P<0.05); IL-2 levels were lower in ALL patients. No significant differences were observed in the levels of CD4+CD25+ Treg cells, IL-2, IL-10 or TGF-β in B-ALL versus T-ALL patients. The authors concluded that CD19 and CD7 may serve as diagnostic markers of B-ALL and T-ALL, respectively. The increased presence of CD4+CD25+ Treg cells and the altered levels of secreted cytokines are indicative of an immunosuppressive mechanism in the pathogenesis of ALL.
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February 2012
Volume 3 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Impact Factor: 2.5
  • Ranked Oncology
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Wu C, Qing X, Wu C, Zhu H and Zhou H: Immunophenotype and increased presence of CD4+CD25+ regulatory T cells in patients with acute lymphoblastic leukemia. Oncol Lett 3: 421-424, 2012.
APA
Wu, C., Qing, X., Wu, C., Zhu, H., & Zhou, H. (2012). Immunophenotype and increased presence of CD4+CD25+ regulatory T cells in patients with acute lymphoblastic leukemia. Oncology Letters, 3, 421-424. https://doi.org/10.3892/ol.2011.499
MLA
Wu, C., Qing, X., Wu, C., Zhu, H., Zhou, H."Immunophenotype and increased presence of CD4+CD25+ regulatory T cells in patients with acute lymphoblastic leukemia". Oncology Letters 3.2 (2012): 421-424.
Chicago
Wu, C., Qing, X., Wu, C., Zhu, H., Zhou, H."Immunophenotype and increased presence of CD4+CD25+ regulatory T cells in patients with acute lymphoblastic leukemia". Oncology Letters 3, no. 2 (2012): 421-424. https://doi.org/10.3892/ol.2011.499