Meningeal tumor: A rare extrahepatic association in patients with polycystic liver disease enrolled for liver transplantation

Bakonyi Neto,Alexandre; Zanini,Marco   Antonio; Cavalheiro da Silva,Amanda  Pinter; Winckler,Camila; Mattos dos Santos,Rodrigo; Lopes Furtado,Marcelo

doi:10.3892/ol.2012.605

Meningeal tumor: A rare extrahepatic association in patients with polycystic liver disease enrolled for liver transplantation

Authors:
- Alexandre Bakonyi Neto
- Marco Antonio Zanini
- Amanda Pinter Cavalheiro da Silva
- Camila Winckler
- Rodrigo Mattos dos Santos
- Marcelo Lopes Furtado
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Affiliations: Department of Surgery, Division of Gastrointestinal Transplant, Botucatu Faculty of Medicine, UNESP, Botucatu, SP, Brazil, Department of Neurosurgery, Botucatu Faculty of Medicine, UNESP, Botucatu, SP, Brazil, Department of Urology, Botucatu Faculty of Medicine, UNESP, Botucatu, SP, Brazil
Published online on: February 10, 2012 https://doi.org/10.3892/ol.2012.605
Pages: 1007-1010

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Abstract

In the present study, we described a rare association of polycystic liver disease (PCLD) with intracranial meningiomas in patients included on a liver transplant list, focusing on the diagnosis, treatment and possible association with any genetic alterations. Two female patients, aged 39 and 49 years were included on a liver transplant list due to extensive PCLD, with symptoms related to an abdominal compartmental syndrome. Screening for extrahepatic manifestation revealed a right frontal meningioma in the first patient, and a parietal posterior calcified meningioma in the second patient, measuring 1 and 7x3x2 cm in diameter, respectively. Following tumor removal, the histological pattern was compatible with fibrous and transitional meningioma, respectively. Cytogenetic studies conducted following surgery did not reveal any changes in metaphase chromosomes. The postoperative follow-up for the two patients was uneventful, without complications, with the patients remaining on a liver transplant waiting list. We conclude that screening for extrahepatic manifestations of PCLD is mandatory, as certain lesions require treatment prior to liver transplantation. The lack of a genetic or familial association between these two cases show they are likely to have occurred by chance, rather than representing a previously unrecognized association between polycystic liver disease and cranial meningioma.

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