Clinicopathological characteristics of rectal carcinoid patients undergoing surgical resection

Yamagishi,Daisuke; Matsubara,Nagahide; Noda,Masafumi; Yamano,Tomoki; Tsukamoto,Kiyoshi; Kuno,Takashi; Hamanaka,Mie; Kobayashi,Masayoshi; Ikeuchi,Hiroki; Matsuda,Ikuo; Hirota,Seiichi; Tomita,Naohiro

doi:10.3892/ol.2012.868

Clinicopathological characteristics of rectal carcinoid patients undergoing surgical resection

Authors:
- Daisuke Yamagishi
- Nagahide Matsubara
- Masafumi Noda
- Tomoki Yamano
- Kiyoshi Tsukamoto
- Takashi Kuno
- Mie Hamanaka
- Masayoshi Kobayashi
- Hiroki Ikeuchi
- Ikuo Matsuda
- Seiichi Hirota
- Naohiro Tomita
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Affiliations: Division of Lower GI, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, Division of Lower GI, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Published online on: August 20, 2012 https://doi.org/10.3892/ol.2012.868
Pages: 910-914

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Abstract

The aim of this study was to clarify the clinical aspects, histopathological features and prognosis of patients with rectal carcinoids, focusing on properties associated with metastasis, in order to gain insights into appropriate management. A total of 20 patients (15 males, 5 females; mean age, 54.9 years; range, 23-71) who underwent surgery for rectal carcinoid tumors at the Department of Colorectal Surgery, Hyogo College of Medicine, between May 2000 and January 2011 were analyzed. Ki-67 immunostaining was performed in 13 cases with available tumor tissue specimens. Of the 20 patients, a radical operation including rectal resection with a lymphadenectomy was performed in 16. The mean tumor size was 11.9 mm (3-25 mm) and lymph node metastasis was confirmed in 9 cases, including 3 with lesions no greater than 7 mm in diameter. Overall, 16 (80%) of the tumors were localized in the submucosal layer and 4 (20%) involved the proper muscle layer. Ki-67 labeling index and lymphovascular invasion were shown to be associated with lymph node and/or distant metastasis by multiple logistic regression analysis, but were not statistically significant in ANOVA findings. Lymph node metastasis from rectal carcinoids, even those smaller than 10 mm in diameter, was not a rare event. More attention should be given to decision-making, including the possibility of endoscopic resection for the treatment of rectal carcinoid tumors regardless of size.

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