RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells

  • Authors:
    • Zhong Zheng
    • Xiang-Yi He
    • Jian-Fang Li
    • Bei-Qin Yu
    • Xue-Hua Chen
    • Jun  Ji
    • Jia-Nian Zhang
    • Qin-Long Gu
    • Zheng-Gang Zhu
    • Bing-Ya Liu
  • View Affiliations

  • Published online on: October 1, 2012     https://doi.org/10.3892/ol.2012.949
  • Pages: 255-260
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Abstract

Resistance to 5-fluorouracil (5-FU) in patients with gastric cancer is a serious therapeutic problem and major efforts are underway to understand the underlying mechanisms. We have previously identified RhoGDI2 as a contributor to 5-FU resistance in colon cancer cells using 2D electrophoresis and mass spectrometry and the current study aimed to further investigate this role. The expression of RhoGDI2 in seven gastric cancer cell lines was positively correlated with resistance to 5-FU. Lower 5-FU sensitivity of isolated tumor cells from patients with gastric cancer was also associated with higher RhoGDI2 expression. Ectopic expression of RhoGDI2 in gastric cancer cells increased the resistance to 5-FU and reverted low dose 5-FU-induced G2/M phase arrest without affecting the population of sub-G1 cells. Overall, these findings suggest that RhoGDI2 is associated with 5-FU resistance and is a potential therapeutic target for enhancing chemotherapy efficacy in gastric cancer.
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January 2013
Volume 5 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zheng Z, He X, Li J, Yu B, Chen X, Ji J, Zhang J, Gu Q, Zhu Z, Liu B, Liu B, et al: RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells. Oncol Lett 5: 255-260, 2013.
APA
Zheng, Z., He, X., Li, J., Yu, B., Chen, X., Ji, J. ... Liu, B. (2013). RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells. Oncology Letters, 5, 255-260. https://doi.org/10.3892/ol.2012.949
MLA
Zheng, Z., He, X., Li, J., Yu, B., Chen, X., Ji, J., Zhang, J., Gu, Q., Zhu, Z., Liu, B."RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells". Oncology Letters 5.1 (2013): 255-260.
Chicago
Zheng, Z., He, X., Li, J., Yu, B., Chen, X., Ji, J., Zhang, J., Gu, Q., Zhu, Z., Liu, B."RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells". Oncology Letters 5, no. 1 (2013): 255-260. https://doi.org/10.3892/ol.2012.949