Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer

  • Authors:
    • Guo-An Zhang
    • Sen Hou
    • Sha Han
    • Jian Zhou
    • Xu Wang
    • Wen Cui
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  • Published online on: January 10, 2013     https://doi.org/10.3892/ol.2013.1125
  • Pages: 797-800
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Abstract

The role of leptin and its receptors (OBRs) in the pathogenesis of various primary human malignancies has been demonstrated. However, their expression and clinicopathological significance in papillary thyroid cancer (PTC) is not fully understood. In this study, we examined the expression of leptin and OBRs in 76 PTC samples using immunohistochemistry, and their associations with clinicopathological parameters were evaluated. The expression of OBRs was observed in the tumor cell membrane and/or cytoplasm, with a positive rate of 73.7% (56/76), while leptin was expressed in the tumor cell cytoplasm in 55 of 76 cases (72.4%). The expression of either protein was associated with greater tumor size (P=0.016 for leptin and P=0.002 for OBRs). In addition, the expression levels of leptin and OBRs were associated with each other. Neither leptin nor OBR expression levels were associated with other parameters, including age, body weight, postmenopausal state, multifocality and lymph node metastasis. These data suggest that the expression of leptin and/or OBRs in PTC is associated with tumor size and may be a potential target in PTC.
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March 2013
Volume 5 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang G, Hou S, Han S, Zhou J, Wang X and Cui W: Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer. Oncol Lett 5: 797-800, 2013.
APA
Zhang, G., Hou, S., Han, S., Zhou, J., Wang, X., & Cui, W. (2013). Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer. Oncology Letters, 5, 797-800. https://doi.org/10.3892/ol.2013.1125
MLA
Zhang, G., Hou, S., Han, S., Zhou, J., Wang, X., Cui, W."Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer". Oncology Letters 5.3 (2013): 797-800.
Chicago
Zhang, G., Hou, S., Han, S., Zhou, J., Wang, X., Cui, W."Clinicopathological implications of leptin and leptin receptor expression in papillary thyroid cancer". Oncology Letters 5, no. 3 (2013): 797-800. https://doi.org/10.3892/ol.2013.1125