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Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand‑1 surface expression

  • Authors:
    • Wanlu Lu
    • Libing Lu
    • Yun Feng
    • Jiao Chen
    • Yan Li
    • Xiangli Kong
    • Sixiu Chen
    • Xiaoyu Li
    • Qianming Chen
    • Ping Zhang

  • View Affiliations

  • Published online on: March 8, 2013     https://doi.org/10.3892/ol.2013.1238
  • Pages: 1519-1526
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The association between inflammation and cancer provides a new target for tumor biotherapy. The inflammatory cells and molecules within the tumor microenvironment have decisive dual roles in antitumor immunity and immune evasion. In the present study, phytohemagglutinin (PHA) was used to stimulate peripheral blood mononuclear cells (PBMCs) to simulate the tumor inflammatory microenvironment. The effect of immune cells and inflammatory cytokines on the surface expression of programmed cell death‑1 ligand 1 (PD‑L1) and tumor immune evasion was investigated using flow cytometry (FCM) and an in vivo xenotransplantation model. Based on the data, PHA‑activated, but not resting, immune cells were able to promote the surface expression of PD‑L1 in Tca8113 oral squamous carcinoma cells via the secretion of inflammatory cytokines, but not by cell‑cell contact. The majority of the inflammatory cytokines had no significant effect on the proliferation, cell cycle progression and apoptosis of the Tca8113 cells, although they each induced the expression of PD‑L1 in a dose‑dependent manner. In total, 99% of the Tca8113 cells expressed PD‑L1 following treatment with the supernatant of PHA‑stimulated PBMCs. The PHA‑supernatant pretreated Tca8113 cells unusually induced Tca8113 antigen‑specific CD8+ T cell apoptosis in vitro and the evasion of antigen‑specific T cell attraction in a nude mouse tumor‑bearing model. These results indicate a new mechanism for the promotion of tumor immune evasion by the tumor inflammatory microenvironment.
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May 2013
Volume 5 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • Journal Metrics
  • Impact Factor: 2.5
  • Ranked Oncology
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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Lu W, Lu L, Feng Y, Chen J, Li Y, Kong X, Chen S, Li X, Chen Q, Zhang P, Zhang P, et al: Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand‑1 surface expression. Oncol Lett 5: 1519-1526, 2013
APA
Lu, W., Lu, L., Feng, Y., Chen, J., Li, Y., Kong, X. ... Zhang, P. (2013). Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand‑1 surface expression. Oncology Letters, 5, 1519-1526. https://doi.org/10.3892/ol.2013.1238
MLA
Lu, W., Lu, L., Feng, Y., Chen, J., Li, Y., Kong, X., Chen, S., Li, X., Chen, Q., Zhang, P."Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand‑1 surface expression". Oncology Letters 5.5 (2013): 1519-1526.
Chicago
Lu, W., Lu, L., Feng, Y., Chen, J., Li, Y., Kong, X., Chen, S., Li, X., Chen, Q., Zhang, P."Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand‑1 surface expression". Oncology Letters 5, no. 5 (2013): 1519-1526. https://doi.org/10.3892/ol.2013.1238