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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May 2013 Volume 5 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Clinical implications of Girdin and PI3K protein expression in breast cancer

  • Authors:
    • Feng Jin
    • Caigang Liu
    • Yang Guo
    • Hao Chen
    • Yunfei Wu
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, General Surgery, The First Hospital of China Medical University, Shenyang 110001, P.R. China
  • Pages: 1549-1553
    |
    Published online on: March 12, 2013
       https://doi.org/10.3892/ol.2013.1249
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Abstract

The aim of this study was to investigate the correlation between Girdin and PI3K in breast cancer stem cells and the clinical implications of the co-expression of these two proteins in breast cancer patients. CD44+/CD24- tumor cells from the MD-231 cell line were sorted by flow cytometry. The expression status of Girdin and PI3K proteins was detected using western blotting and immunohistochemical staining. The relationship between Girdin and PI3K proteins and clinicopathological parameters was analyzed in 820 breast cancer patients. Girdin and PI3K proteins were more highly expressed in CD44+/CD24- tumor stem cells compared to the control group and Girdin and PI3K proteins were co-immunoprecipitated in the MD-231 cell line. Of the 820 enrolled breast cancer patients, Girdin and PI3K proteins were expressed in 295 (35.98%) and 492 (60.00%) cases, respectively. There were 162 (19.76%) cases which co-expressed Girdin and PI3K proteins. Univariate and multivariate analyses indicated that the co-expression of Girdin and PI3K proteins correlated with histological type, metastatic nodes and distant metastasis (P=0.01, 0.001 and 0.001, respectively). After analyzing survival rates, cases with Girdin and PI3K co-expression were shown to attain a significantly increased distant metastasis rate and poorer postoperative, disease-specific survival compared to those with Girdin and PI3K co-expression (P=0.001). In the Cox regression test, Girdin and PI3K co-expression was detected as an independent prognostic factor (P=0.001). Girdin may regulate the biological behavior of breast cancer via the PI3K/Akt/mTOR pathway, and thus, serve as a potential new target for breast cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Jin F, Liu C, Guo Y, Chen H and Wu Y: Clinical implications of Girdin and PI3K protein expression in breast cancer. Oncol Lett 5: 1549-1553, 2013.
APA
Jin, F., Liu, C., Guo, Y., Chen, H., & Wu, Y. (2013). Clinical implications of Girdin and PI3K protein expression in breast cancer. Oncology Letters, 5, 1549-1553. https://doi.org/10.3892/ol.2013.1249
MLA
Jin, F., Liu, C., Guo, Y., Chen, H., Wu, Y."Clinical implications of Girdin and PI3K protein expression in breast cancer". Oncology Letters 5.5 (2013): 1549-1553.
Chicago
Jin, F., Liu, C., Guo, Y., Chen, H., Wu, Y."Clinical implications of Girdin and PI3K protein expression in breast cancer". Oncology Letters 5, no. 5 (2013): 1549-1553. https://doi.org/10.3892/ol.2013.1249
Copy and paste a formatted citation
x
Spandidos Publications style
Jin F, Liu C, Guo Y, Chen H and Wu Y: Clinical implications of Girdin and PI3K protein expression in breast cancer. Oncol Lett 5: 1549-1553, 2013.
APA
Jin, F., Liu, C., Guo, Y., Chen, H., & Wu, Y. (2013). Clinical implications of Girdin and PI3K protein expression in breast cancer. Oncology Letters, 5, 1549-1553. https://doi.org/10.3892/ol.2013.1249
MLA
Jin, F., Liu, C., Guo, Y., Chen, H., Wu, Y."Clinical implications of Girdin and PI3K protein expression in breast cancer". Oncology Letters 5.5 (2013): 1549-1553.
Chicago
Jin, F., Liu, C., Guo, Y., Chen, H., Wu, Y."Clinical implications of Girdin and PI3K protein expression in breast cancer". Oncology Letters 5, no. 5 (2013): 1549-1553. https://doi.org/10.3892/ol.2013.1249
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