Prognostic factors associated with locally recurrent rectal cancer following primary surgery (Review)

Cai,Yantao; Li,Zhenyang; Gu,Xiaodong; Fang,Yantian; Xiang,Jianbin; Chen,Zongyou

doi:10.3892/ol.2013.1640

Prognostic factors associated with locally recurrent rectal cancer following primary surgery (Review)

Authors:
- Yantao Cai
- Zhenyang Li
- Xiaodong Gu
- Yantian Fang
- Jianbin Xiang
- Zongyou Chen
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Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
Published online on: October 23, 2013 https://doi.org/10.3892/ol.2013.1640
Pages: 10-16

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Abstract

Locally recurrent rectal cancer (LRRC) is defined as an intrapelvic recurrence following a primary rectal cancer resection, with or without distal metastasis. The treatment of LRRC remains a clinical challenge. LRRC has been regarded as an incurable disease state leading to a poor quality of life and a limited survival time. However, curative reoperations have proved beneficial for treating LRRC. A complete resection of recurrent tumors (R0 resection) allows the treatment to be curative rather than palliative, which is a milestone in medicine. In LRRC cases, the difficulty of achieving an R0 resection is associated with the post‑operative prognosis and is affected by several clinical factors, including the staging of the local recurrence (LR), accompanying symptoms, patterns of tumors and combined therapy. The risk factors following primary surgery that lead to an increased rate of LR are summarized in this study, including the surgical, pathological and therapeutic factors.

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