Open Access

TRAIL combinations: The new ‘trail’ for cancer therapy (Review)

  • Authors:
    • Alaa Refaat
    • Ahmed Abd‑Rabou
    • Asmaa Reda
  • View Affiliations

  • Published online on: February 27, 2014     https://doi.org/10.3892/ol.2014.1922
  • Pages: 1327-1332
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Abstract

Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) therapy is anticipated to be one of the most effective cancer treatments. However, resistance to TRAIL therapy remains a challenge facing the development of anticancer strategies. To circumvent this problem, TRAIL combinations have been experimented with for over ten years to induce synergism or sensitize resistant cancer cells. By analyzing the signaling pathways triggered by these combinations, this review has defined a set of core targets for novel combinatorial treatments. The review suggests specific pathways to be targeted together with TRAIL for more efficient treatment, including cellular FLICE inhibitory protein and its downstream survival factors, the Bcl‑2 family and other prominent targets. The suggested pathways provide new avenues for more effective TRAIL‑based cancer therapy.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Refaat A, Abd‑Rabou A and Reda A: TRAIL combinations: The new ‘trail’ for cancer therapy (Review). Oncol Lett 7: 1327-1332, 2014.
APA
Refaat, A., Abd‑Rabou, A., & Reda, A. (2014). TRAIL combinations: The new ‘trail’ for cancer therapy (Review). Oncology Letters, 7, 1327-1332. https://doi.org/10.3892/ol.2014.1922
MLA
Refaat, A., Abd‑Rabou, A., Reda, A."TRAIL combinations: The new ‘trail’ for cancer therapy (Review)". Oncology Letters 7.5 (2014): 1327-1332.
Chicago
Refaat, A., Abd‑Rabou, A., Reda, A."TRAIL combinations: The new ‘trail’ for cancer therapy (Review)". Oncology Letters 7, no. 5 (2014): 1327-1332. https://doi.org/10.3892/ol.2014.1922