Giant cell tumor of the occipital bone: A case report and review of the literature

Uslu,Gonca Hanedan; Canyilmaz,Emine; Yöney,Adnan; Aydin,Sevdegül; Şahbaz,Aslı; Sarı,Ahmet

doi:10.3892/ol.2014.2086

Giant cell tumor of the occipital bone: A case report and review of the literature

Authors:
- Gonca Hanedan Uslu
- Emine Canyilmaz
- Adnan Yöney
- Sevdegül Aydin
- Aslı Şahbaz
- Ahmet Sarı
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Affiliations: Department of Radiation Oncology, Kanuni Research and Education Hospital, Trabzon 60080, Turkey, Department of Radiation Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey, Department of Pathology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey, Department of Radiology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey
Published online on: April 25, 2014 https://doi.org/10.3892/ol.2014.2086
Pages: 151-154

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Abstract

Giant cell tumors (GCTs) are usually found in the epiphysis of the long bones, and represent ~5% of all bone tumors. Only <1% of GCTs are localized in the cranium. When localized in the cranium, GCTs are commonly observed in the sphenoid or temporal bones, and rarely in the parietal or frontal bones. Occipital bone posterior fossa involvement is an extremely rare occurrence. The current study presents a 22‑year‑old female patient was admitted to the Department of Radiation Oncology (Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey) with complaints of neck pain and headache. The patients cranial magnetic resonance images showed a 2.5 6‑cm mass in the occipital bone, which was subtotally excised. The patient was treated with radiotherapy following the surgery. At present, the patient has shown no progression after 20 months of follow‑up.

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1	Bertoni F, Unni KK, Beabout JW and Ebersold MJ: Giant cell tumor of the skull. Cancer. 70:1124–1132. 1992.
2	Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT and Kransdorf MJ: From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 21:1283–1309. 2001.
3	Seider MJ, Rich TA, Ayala AG and Murray J: Giant cell Tumor of bone: treatment with radiation therapy. Radiology. 16:537–540. 1986.
4	Reed L, Willison CD, Schochet SS Jr and Voelker JL: Giant cell tumor of the calvaria in a child: Case report. J Neurosurg. 80:148–151. 1994.
5	Leggon RE, Zlotecki R, Reith J and Scarborough MT: Giant cell tumor of the pelvis and sacrum. Clin Orthop Relat Res. 423:196–207. 2004.
6	McGrath PJ: Giant-cell tumor of bone: an analysis of fifty-two cases. J Bone Joint Surg Br. 54:216–229. 1972.
7	Goldenberg RR, Campbell CJ and Bonfiglio M: Giant-cell tumor of bone: An analysis of two hundred and eighteen cases. J Bone Joint Surg Am. 52:619–664. 1970.
8	Malone S, O’Sullivan B, Catton C, Bell R, Fornasier V and Davis A: Long-term follow up of efficacy and safety of megavoltage radiotherapy in high risk giant cell tumors of bone. Int J Radiat Biol Oncol Phys. 33:689–694. 1995.
9	Elder JB, Berry C, Gonzalez-Gomez I, Kreger MD and McComb JG: Giant cell tumor of the skull in pediatric patients. Report of two cases. J Neurosurg. 107:69–74. 2007.
10	Yamamoto M, Fukushima T, Sakamoto S and Tomonaga M: Giant cell tumor of sphenoid bone: long-term follow-up of two cases after chemotherapy. Surg Neurol. 49:547–552. 1998.
11	Germanò A, Caruso G, Caffo M, Galatioto S, Belvedere M and Cardia E: Temporal osteoclastoma: an exceptional lesion in infancy. Childs Nerv Syst. 14:213–217. 1998.
12	Campanacci M, Baldini N, Boriani S and Sudanese A: Giant-cell tumor of bone. J Bone Joint Surg Am. 69:106–114. 1987.
13	Arseni C, Horvath L, Maretsis M and Carp N: Giant cell tumors of the calvaria. J Neurosurg. 42:535–540. 1975.
14	Gebhart M, Vandeweyer E and Nemec E: Paget’s disease of bone complicated by giant cell tumor. Clin Orthop Relat Res. 352:187–193. 1998.
15	Lu ZH and Yao ZW: Giant-cell tumour of the posterior cranial fossa: a case report. Br J Radiol. 84:e206–e209. 2011.
16	Opitz H, Petersen D, Heiss E, Duffner F and Meyermann R: Giant cell tumor of the occipital bone in a case of von Recklinghausen neurofibromatosis. Clin Neuropathol. 15:226–230. 1996.
17	Usul H, Kuzeyli K, Çakir E, Karaarslan G, Arslan E, Yazar U and Arslan S: Dumbbell shaped giant cell tumor of the temporal bone: case report and literature review. Turkish Neurosurgery. 14:112–116. 2004.
18	Rosen MP: General diagnosis case of the day. Giant cell tumor of the temporal bone. AJR Am J Roentgenol. 156:1290–1292. 1991.
19	Mendenhall WM, Zlotecki RA, Scarborough MT, Gibbs CP and Mendenhall NP: giant cell tumor of bone. Am J Clin Oncol. 29:96–99. 2006.
20	Chakravarti A, Spiro IJ, Hug EB, Mankin HJ, Efird JT and Suit HD: Megavoltage radiation therapy for axial and inoperable giant-cell tumor of bone. J Bone Joint Surg Am. 81:1566–1573. 1999.
21	Carrasco CH and Murray JA: Giant cell tumors. Orthop Clin North Am. 20:395–405. 1989.
22	Wolfe JT III, Scheithauer BW and Dahlin CD: Giant-cell tumor of the sphenoid bone. J Neurosurg. 59:322–327. 1983.
23	Coumbaras M, Pierot L, Felgeres AA, Boulin A, Gaillard S and Derome PJ: Giant-cell tumour involving the cranial vault: imaging and treatment. Neuroradiology. 41:826–828. 1999.
24	Ulu MO, Biceroglu H, Ozlen F, Oz B and Gazioglu N: Giant cell tumor of the frontal bone in an 18-month-old girl: a case report. Cent Eur Neurosurg. 71:104–107. 2010.
25	Roeder F, Timke C, Zwicker F, Thieke C, Bischof M, Debus J and Huber PE: Intensity modulated radiotherapy (IMRT) in benign giant cell tumors-a single institution case series and a short review of the literature. Radiat Oncol. 26:1–7. 2010.
26	Feigenberg SJ, Marcus RB, Zlotecki RA, Scarborough MT, Berrey BH and Enneking WF: Radiation Therapy for Giant cell tumors of bone. Int J Radiat Oncol Biol Phys. 49:1243–1247. 2001.