Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)

Caruso,Rosario  A.; Branca,Giovanni; Fedele,Francesco; Irato,Eleonora; Finocchiaro,Giuseppe; Parisi,Antonio; Ieni,Antonio

doi:10.3892/ol.2014.2345

Mechanisms of coagulative necrosis in malignant epithelial tumors (Review)

Authors:
- Rosario A. Caruso
- Giovanni Branca
- Francesco Fedele
- Eleonora Irato
- Giuseppe Finocchiaro
- Antonio Parisi
- Antonio Ieni
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Affiliations: Department of Human Pathology, University of Messina, Messina I-98125, Italy, Department of Surgical Science, University of Messina, Messina I-98125, Italy
Published online on: July 11, 2014 https://doi.org/10.3892/ol.2014.2345
Pages: 1397-1402

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Abstract

Histological tumor necrosis (TN) has been reported to indicate a poor prognosis for different human cancers. It is generally accepted that TN results from chronic ischemic injury due to rapid tumor growth. However, whether insufficient tumor vascularization and inadequate tumor cell oxygenation are the only factors causing TN remains controversial. Mitotic catastrophe is considered to occur as a result of dysregulated/failed mitosis, leading to cell death. We hypothesize that mitotic catastrophe, induced by hypoxic stress, may lead to the TN which is observed in high grade carcinomas. The current review describes the morphological features of TN in malignant epithelial tumors. In addition, evidence regarding the involvement of mitotic catastrophe in the induction of TN in human carcinomas is discussed.

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