Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma

  • Authors:
    • Manabu Hoshi
    • Naoto Oebisu
    • Jun Takada
    • Tdashi Iwai
    • Hiroaki Nakamura
  • View Affiliations

  • Published online on: January 5, 2015     https://doi.org/10.3892/ol.2015.2844
  • Pages: 1409-1411
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Abstract

The current study presents the case of a 59‑year‑old male with advanced‑stage renal cell carcinoma and bone metastases in the proximal femur and ilium (cT3aN3M1; stage IV). Resection of the primary renal cell cancer and palliative surgery with a γ‑nail for an impending fracture of the right proximal femur were performed, followed by radiotherapy. Sorafenib, a multi‑kinase inhibitor that blocks the raf and tyrosine kinases of the vascular endothelial and platelet‑derived growth factor receptors, was administered for 9 months, resulting in a marked improvement in the metastatic ilium and a reduction in the extent of the lung metastases. The patient suffered minor adverse effects, including a skin rash and mild diarrhea, but remained alive at the time of follow‑up at 36 months post‑surgery. Sorafenib demonstrated efficacy against the bone metastasis of metastatic renal cell carcinoma.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hoshi M, Oebisu N, Takada J, Iwai T and Nakamura H: Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma. Oncol Lett 9: 1409-1411, 2015.
APA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., & Nakamura, H. (2015). Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma. Oncology Letters, 9, 1409-1411. https://doi.org/10.3892/ol.2015.2844
MLA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Nakamura, H."Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma". Oncology Letters 9.3 (2015): 1409-1411.
Chicago
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Nakamura, H."Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma". Oncology Letters 9, no. 3 (2015): 1409-1411. https://doi.org/10.3892/ol.2015.2844