Benign pulmonary metastasizing leiomyoma of the uterus: A case report
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Affiliations: Respiratory Department, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
- Published online on: January 15, 2015 https://doi.org/10.3892/ol.2015.2878
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1347-1350
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Abstract
Pulmonary benign metastasizing leiomyoma (BML), is characterized by multiple pulmonary nodular lesions and is a rare disease. The present study reports the case of a 45‑year‑old asymptomatic woman who underwent an excision of uterine leiomyoma 11 years previously. Chest computed tomography (CT) revealed multiple bilateral pulmonary nodules five months prior to admission, during a regular check‑up. Intravenous levofloxacin (0.5 g/day) was administered for one week, which demonstrated no effect. Positron emission tomography combined with CT (PET/CT) revealed no evident radioactivity concentration. Due to the suspicion of metastasizing leiomyoma, video‑assisted thoracoscopic surgery, with a wedge resection of the right pulmonary lesion, was performed. Post‑operative pathological examination revealed the lesion to be a pulmonary leiomyoma accompanied by local necrosis. Immunohistochemical staining revealed that the lesion was positive for the expression of smooth muscle actin, desmin, estrogen receptor, progesterone receptor and B‑cell lymphoma‑2. Cytokeratin and epithelial membrane antigen were not expressed in the tumor cells. Staining for Ki‑67 revealed expression of Ki‑67 in ~1% of the spindle cells. The overall morphological and immunohistochemical features, accompanied by the remote patient history of primary uterine leiomyoma, supported the diagnosis of pulmonary BML.
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