Acute myeloid leukemia with monosomy 7, ectopic virus integration site-1 overexpression and central diabetes insipidus: 
A case report

Ma,Hongbing; Yang,Jing; Xiang,Bing; Jia,Yongqian

doi:10.3892/ol.2015.3139

Acute myeloid leukemia with monosomy 7, ectopic virus integration site-1 overexpression and central diabetes insipidus: A case report

Authors:
- Hongbing Ma
- Jing Yang
- Bing Xiang
- Yongqian Jia
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Affiliations: Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: April 23, 2015 https://doi.org/10.3892/ol.2015.3139
Pages: 2459-2462
Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Central diabetes insipidus (DI) is a rare complication in patients with acute myeloid leukemia (AML), typically occurring in patients with abnormalities of chromosomes 3 or 7. The association between AML with monosomy 7 and DI has been described in a number of studies; however, DI has been rarely reported in cases of ectopic virus integration site‑1 (EVI1)‑positive AML with monosomy 7. The current study reports a case of AML with monosomy 7 and EVI1 overexpression, with central DI as the initial symptom. The patient was an 18‑year‑old female who presented with polyuria and polydipsia. Bone marrow aspiration revealed 83.5% myeloperoxidase‑positive blasts without trilineage myelodysplasia. The karyotype was 45,XX,‑7, and the patient presented monosomy 7 and EVI1 overexpression (‑7/EVI1+) without 3q aberration. Treatment with induction therapy was unsuccessful. To the best of our knowledge, this is the second case of DI‑AML with ‑7/EVI1+ and without a 3q aberration. The possible mechanisms associated with EVI1, monosomy 7 and DI were investigated.

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1	Hasserjian RP: Acute myeloid leukemia: advances in diagnosis and classification. Int J Lab Hematol. 35:358–366. 2013. View Article : Google Scholar : PubMed/NCBI
2	Kimmel DW and O'Neill BP: Systemic cancer presenting as diabetes insipidus. Clinical and radiographic features of 11 patients with a review of metastatic-induced diabetes insipidus. Cancer. 52:2355–2358. 1983. View Article : Google Scholar : PubMed/NCBI
3	Maghnie M, Cosi G, Genovese E, et al: Central diabetes insipidus in children and young adults. N Engl J Med. 343:998–1007. 2000. View Article : Google Scholar : PubMed/NCBI
4	Castagnola C, Morra E, Bernasconi P, Astori C, Santagostino A and Bernasconi C: Acute myeloid leukemia and diabetes insipidus: results in 5 patients. Acta Haematol. 93:1–4. 1995. View Article : Google Scholar : PubMed/NCBI
5	Nieboer P, Vellenga E, Adriaanse R and van de Loosdrecht AA: Central diabetes insipidus preceding acute myeloid leukemia with t(3;12)(q26;p12). Neth J Med. 56:45–47. 2000. View Article : Google Scholar : PubMed/NCBI
6	Wössmann W, Borkhardt A, Gossen R, Göbel FJ and Reiter A: Acute myeloid leukemia presenting with diabetes insipidus. Eur J Pediatr. 161:161–162. 2002. View Article : Google Scholar : PubMed/NCBI
7	Harb A, Tan W, Wilding GE, Battiwalla M, Sait SN, Wang ES and Wetzler M: Acute myeloid leukemia and diabetes insipidus with monosomy 7. Cancer Genet Cytogenet. 190:97–100. 2009. View Article : Google Scholar : PubMed/NCBI
8	Saborio P, Tipton GA and Chan JC: Diabetes insipidus. Pediatr Rev. 21:122–129. 2000. View Article : Google Scholar : PubMed/NCBI
9	de la Chapelle A and Lahtinen R: Monosomy 7 predisposes to diabetes insipidus in leukaemia and myelodysplastic syndrome. Eur J Haematol. 39:404–411. 1987. View Article : Google Scholar : PubMed/NCBI
10	Müller CI, Engelhardt M, Laubenberger J, et al: Myelodysplastic syndrome in transformation to acute leukemia presenting with diabetes insipidus: Due to pituitary infiltration association with abnormalities of chromosome 3 and 7. Eur J Haematol. 69:115–119. 2002. View Article : Google Scholar : PubMed/NCBI
11	Martinelli G, Ottaviani E, Buonamici S, et al: Association of 3q21q26 syndrome with different RPN1/EVI1 fusion transcripts. Haematologica. 88:1221–1228. 2003.PubMed/NCBI
12	Jółkowska J and Witt M: The EVI-1 gene - its role in pathogenesis of human leukemias. Leuk Res. 24:553–558. 2000. View Article : Google Scholar : PubMed/NCBI
13	Gröschel S, Lugthart S, Schlenk RF, et al: High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities. J Clin Oncol. 28:2101–2107. 2010. View Article : Google Scholar : PubMed/NCBI
14	Catovsky D, Matutes E, Buccheri V, Shetty V, Hanslip J, Yoshida N and Morilla R: A classification of acute leukaemia for the 1990s. Ann Hematol. 62:16–21. 1991. View Article : Google Scholar : PubMed/NCBI
15	Montecucco C, Cazzola M and Ascari E: Diabetes insipidus in the preleukaemic phase of acute non-lymphocytic leukaemia. A monosomy 7-associated condition? Scand J Haematol. 33:326–327. 1984. View Article : Google Scholar : PubMed/NCBI
16	Piccin A, Raimondi R, Laspina S, Marchi M, Rodeghiero F and Rovigatti U: Erythroleukaemia, diabetes insipidus and hypophyseal damage: Two case reports. Leuk Res. 31:1135–1139. 2007. View Article : Google Scholar : PubMed/NCBI
17	Lavabre-Bertrand T, Bourquard P, Chiesa J, Berthéas MF, Lefort G, Taïb J, Lavabre-Bertrand C, Navarro M and Bureau JP: Diabetes insipidus revealing acute myelogenous leukaemia with a high platelet count, monosomy 7 and abnormalities of chromosome 3: a new entity? Eur J Haematol. 66:66–69. 2001. View Article : Google Scholar : PubMed/NCBI
18	Breccia M, Petti MC, Ottaviani E, Mancini M, D'Elia GM, Mecarocci S and Alimena G: Diabetes insipidus as first manifestation of acute myeloid leukaemia with EVI-1-positive, 3q21q26 syndrome and T cell-line antigen expression: what is the EVI-1 gene role? Br J Haematol. 118:438–441. 2002. View Article : Google Scholar : PubMed/NCBI
19	Nussey SS, Ang VT, Bevan DH and Jenkins JS: Human platelet arginine vasopressin. Clin Endocrinol (Oxf). 24:427–433. 1986. View Article : Google Scholar : PubMed/NCBI
20	Dilek I, Uysal A, Demirer T, Koç H, Ozcan M, Keleş H, Numaoğlu N, Ustün C and Ciftçi E: Acute myeloblastic leukemia associated with hyperleukocytosis and diabetes insipidus. Leuk Lymphoma. 30:657–660. 1998.PubMed/NCBI
21	Curley C, Kennedy G, Haughton A, Love A, McCarthy C and Boyd A: Acute myeloid leukemia, the 3q21q26 syndrome and diabetes insipidus: a case presentation. Asia Pac J Clin Oncol. 6:77–79. 2010. View Article : Google Scholar : PubMed/NCBI