The importance of Src signaling in sarcoma (Review)

  • Authors:
    • Quanchi Chen
    • Zifei Zhou
    • Liancheng Shan
    • Hui Zeng
    • Yingqi Hua
    • Zhengdong Cai
  • View Affiliations

  • Published online on: May 6, 2015     https://doi.org/10.3892/ol.2015.3184
  • Pages: 17-22
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Abstract

Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previous studies have suggested that Src has essential functions in cell proliferation, apoptosis, invasion, metastasis and the tumor microenvironment. Thus, it may be a potential target for cancer therapy. Src has been found to enhance proliferation, reduce apoptosis and promote metastasis in certain subtypes of sarcoma, including osteosarcoma, chondrosarcoma and Ewing's sarcoma. Furthermore, a number of novel effective therapeutic agents, such as SI-83, which target Src have been investigated in vitro and in vivo. Bosutinib and dasatinib, which inhibit Src, have been approved by the U.S. Food and Drug Administration for the treatment of chronic myelogenous leukemia. In addition, vandetanib is approved for the treatment of medullary thyroid cancer. Furthermore, the Src inhibitor, saracatinib, is currently in clinical trials for the treatment of a variety of solid tumors, including breast and lung cancers. Thus, Src is considered to be an important factor in sarcoma progression and may present a novel clinical therapeutic target. This review demonstrates the importance and clinical relevance of Src in sarcoma, and discusses a number of small molecular inhibitors of src kinase, such as dasatinib and sarcatinib, which are currently in clinical trials for the treatment of sarcoma patients.
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July-2015
Volume 10 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Q, Zhou Z, Shan L, Zeng H, Hua Y and Cai Z: The importance of Src signaling in sarcoma (Review). Oncol Lett 10: 17-22, 2015.
APA
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., & Cai, Z. (2015). The importance of Src signaling in sarcoma (Review). Oncology Letters, 10, 17-22. https://doi.org/10.3892/ol.2015.3184
MLA
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., Cai, Z."The importance of Src signaling in sarcoma (Review)". Oncology Letters 10.1 (2015): 17-22.
Chicago
Chen, Q., Zhou, Z., Shan, L., Zeng, H., Hua, Y., Cai, Z."The importance of Src signaling in sarcoma (Review)". Oncology Letters 10, no. 1 (2015): 17-22. https://doi.org/10.3892/ol.2015.3184