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Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model

  • Authors:
    • Chuan Wang
    • Ying‑Ge Chen
    • Jian‑Li Gao
    • Gui‑Yuan Lyu
    • Jie Su
    • Qi Zhang
    • Xin Ji
    • Ji-Zhong Yan
    • Qiao‑Li Qiu
    • Yue‑Li Zhang
    • Lin‑Zi Li
    • Han‑Ting Xu
    • Su‑Hong Chen

  • View Affiliations

  • Published online on: June 2, 2015     https://doi.org/10.3892/ol.2015.3304
  • Pages: 754-760

  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It was originally thought that no single routine blood test result would be able to indicate whether or not a patient had cancer; however, several novel studies have indicated that the median survival and prognosis of cancer patients were markedly associated with the systemic circulation features of cancer patients. In addition, certain parameters, such as white blood cell (WBC) count, were largely altered in malignant tumors. In the present study, routine blood tests were performed in order to observe the change of blood cells in tumor‑bearing mice following the implantation of 4T1 breast cancer cells into the mammary fat pad; in addition, blood flow in breast tumor sites was measured indirectly using laser Doppler perfusion imaging (LDPI), in an attempt to explain the relevance between the blood circulation features and the growth or metastasis of breast cancer in mice model. The LDPI and blood test results indicated that the implantation of 4T1 breast cancer cells into BALB/c mice led to thrombosis as well as high WBC count, high platelet count, high plateletcrit and low blood perfusion. Following implantation of the 4T1 cells for four weeks, the lung metastatic number was determined and the Pearson correlation coefficient revealed that the number of visceral lung metastatic sites had a marked negative association with the ratio of basophils (BASO%; r=‑0.512; P<0.01) and the mean corpuscular hemoglobin was significantly correlated with primary tumor weight (r=0.425; P<0.05). In conclusion, the results of the present study demonstrated that tumor growth led to thrombosis and acute anemia in mice; in addition, when blood BASO% was low, an increased number of lung metastases were observed in tumor‑bearing mice.
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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  • CiteScore: 5.7
  • CiteScore Rank: Q2: #139/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.574
  • SCImago Journal Rank (SJR): 0.644
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Spandidos Publications style
Wang C, Chen YG, Gao JL, Lyu GY, Su J, Zhang Q, Ji X, Yan J, Qiu QL, Zhang YL, Zhang YL, et al: Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model. Oncol Lett 10: 754-760, 2015.
APA
Wang, C., Chen, Y., Gao, J., Lyu, G., Su, J., Zhang, Q. ... Chen, S. (2015). Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model. Oncology Letters, 10, 754-760. https://doi.org/10.3892/ol.2015.3304
MLA
Wang, C., Chen, Y., Gao, J., Lyu, G., Su, J., Zhang, Q., Ji, X., Yan, J., Qiu, Q., Zhang, Y., Li, L., Xu, H., Chen, S."Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model". Oncology Letters 10.2 (2015): 754-760.
Chicago
Wang, C., Chen, Y., Gao, J., Lyu, G., Su, J., Zhang, Q., Ji, X., Yan, J., Qiu, Q., Zhang, Y., Li, L., Xu, H., Chen, S."Low local blood perfusion, high white blood cell and high platelet count are associated with primary tumor growth and lung metastasis in a 4T1 mouse breast cancer metastasis model". Oncology Letters 10, no. 2 (2015): 754-760. https://doi.org/10.3892/ol.2015.3304