Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

Takeda,Kenichi; Kudo,Shin‑Ei; Mori,Yuichi; Misawa,Masashi; Kudo,Toyoki; Wakamura,Kunihiko; Hayashi,Takemasa; Miyachi,Hideyuki; Ishida,Fumio; Inoue,Haruhiro

doi:10.3892/ol.2015.3910

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum

Authors:
- Kenichi Takeda
- Shin‑Ei Kudo
- Yuichi Mori
- Masashi Misawa
- Toyoki Kudo
- Kunihiko Wakamura
- Takemasa Hayashi
- Hideyuki Miyachi
- Fumio Ishida
- Haruhiro Inoue
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Affiliations: Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224‑8503, Japan, Digestive Disease Center, Showa University Koto‑Toyosu Hospital, Tokyo 135‑8577, Japan
Published online on: November 10, 2015 https://doi.org/10.3892/ol.2015.3910
Pages: 237-242

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Abstract

A precise endoscopic diagnosis is necessary for endoscopic therapy for neoplastic and non‑neoplastic lesions, including juvenile polyps (JPs). Therefore, the present study aimed to clarify the characteristic endoscopic findings of JPs. A total of 154 JPs were evaluated by magnifying chromoendoscopy, 20 of which were also assessed by endocytoscopy using an ultra‑high magnification endoscope. Endoscopic images were evaluated in terms of gross appearance, color, pit pattern, surface inflammatory changes and vascularity of polyps. Endocytoscopic images were evaluated with regard to the morphology of glandular cavities, nuclei of glandular cells and interstitial features. Reddish surfaces (98.1%), surface erosion (92.2%), open pits (90.3%) and low pit density (90.3%) were observed in the majority of JPs by chromoendoscopy. In addition, dilated ductal openings surrounded by normal glandular cells (100%), greater distances between gland basal layers (100%) and interstitial infiltration by inflammatory cells (100%) were observed in all JPs examined by endocytoscopy. These findings indicate that there is a tetralogy of magnifying chromoendoscopic findings characteristic of JPs: Reddish surfaces, surface erosion, open pits and low pit density. There is also a triad of endocytoscopic findings characteristic of JPs, namely dilated ductal openings surrounded by normal glandular cells, greater distances between gland basal layers, and interstitial infiltration by inflammatory cells. The aforementioned magnifying chromoendoscopic and endocytoscopic characteristics of JPs may be useful factors for diagnosing JPs.

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