Ultra-early microsurgical treatment within 24 h of SAH improves prognosis of poor-grade aneurysm combined with intracerebral hematoma

Chen,Junhui; Zhu,Jun; He,Jianqing; Wang,Yuhai; Chen,Lei; Zhang,Chunlei; Zhou,Jingxu; Yang,Likun

doi:10.3892/ol.2016.4327

Ultra-early microsurgical treatment within 24 h of SAH improves prognosis of poor-grade aneurysm combined with intracerebral hematoma

Authors:
- Junhui Chen
- Jun Zhu
- Jianqing He
- Yuhai Wang
- Lei Chen
- Chunlei Zhang
- Jingxu Zhou
- Likun Yang
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Affiliations: Department of Neurosurgery, Wuxi Clinical Medical School, Anhui Medical University, The 101st Hospital of Chinese People's Liberation Army, Wuxi, Jiangsu 214044, P.R. China
Published online on: March 11, 2016 https://doi.org/10.3892/ol.2016.4327
Pages: 3173-3178

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Abstract

Spontaneous subarachnoid hemorrhage (SAH) is the most common cerebrovascular disease. The conventional treatment for SAH is usually associated with high mortality. The present study aims to assess the prognosis of microsurgical treatment for patients with poor‑grade aneurysm (Hunt and Hess grades IV‑V) associated with intracerebral hematoma. A total of 18 consecutive patients who were diagnosed with poor‑grade aneurysm accompanied with intracerebral hematoma were retrospectively recruited. All patients underwent microsurgical treatment between April 2010 and June 2013 at The 101st Hospital of Chinese People's Liberation Army (Wuxi, China). Among them, 15 cases underwent microsurgery within 24 h of SAH, and 3 cases underwent microsurgery 24 h following SAH. All 18 cases were examined by computed tomography angiography (CTA). The outcome was assessed during a follow‑up time of 6‑36 months. According to the Glasgow Outcome Scale, 4 patients experienced a good recovery, 6 were dissatisfied with the outcome, 4 were in vegetative state and 4 succumbed to disease. Poor outcome occurred in patients with an aneurysm diameter >10 mm, exhibited >50 ml volume of intracerebral hematoma or presented cerebral hernia prior to the surgical operation. The outcome of ultra‑early surgery (within 24 h of SAH) was improved, compared with that of surgery following 24 h of SAH (P=0.005). Among 7 patients who accepted extraventricular drainage, good outcomes were achieved in 4 of them, whereas dissatisfaction and mortality occurred in 2 and 1 patients, respectively. Therefore, ultra-early microsurgery (within 24 h of SAH) combined with extraventricular drainage may improve the prognosis of patients with poor-grade aneurysm.

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