Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature

Gao,Na; Guo,Nong-Jian; Yu,Wen‑Zheng; Wang,Xue‑Xia; Sun,Jian‑Rong; Yu,Ning; Liu,Ren‑Tong; Liu,Xiao‑Dan; Liu,Zeng‑Yan; Feng,Rui

doi:10.3892/ol.2016.4353

Synchronous occurrence of gastrointestinal stromal tumor and acute myeloid leukemia: A case report and review of the literature

Authors:
- Na Gao
- Nong-Jian Guo
- Wen‑Zheng Yu
- Xue‑Xia Wang
- Jian‑Rong Sun
- Ning Yu
- Ren‑Tong Liu
- Xiao‑Dan Liu
- Zeng‑Yan Liu
- Rui Feng
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Affiliations: Department of Hematology, Central Hospital of Jinan, Shandong University School of Medicine, Jinan, Shandong 250013, P.R. China, Department of Hematology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China, Department of Pathology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China
Published online on: March 18, 2016 https://doi.org/10.3892/ol.2016.4353
Pages: 2977-2980
Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastrointestinal stromal tumors (GISTs) originate from the mesenchymal tissue of the gastrointestinal tract. The pathogenesis of GIST is associated with the mutational activation of the receptor tyrosine kinase cluster of differentiation (CD)117 or platelet‑derived growth factor receptor‑α. Overall, ~60% of GISTs occur in the stomach. Clinically, GISTs may coexist with various types of cancer, including liver cancer, pancreatic tumors and lymphoma, either synchronously or metachronously. The present study reports the case of a patient with the synchronous occurrence of a CD117-positive GIST and acute myeloid leukemia. A 69‑year‑old man was hospitalized for heart palpitations and dizziness, and was diagnosed with acute myeloid leukemia (AML) by bone marrow aspiration and flow cytometry analysis. An abdominal computed tomograpy and gastroscopy revealed the presence of GIST. The patient received chemotherapy in combination with imatinib (400 mg/day), and the mass was removed 2 months later. To the best of our knowledge, the present study is the first reported case of the synchronous development of a CD117-positive GIST and AML. Additional studies are required in order to understand the association between GIST and hematological malignancies.

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