Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer (Review)
- Authors:
- Qiao Peng
- Hui Chen
- Ji‑Rong Huo
-
Affiliations: Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China, Department of Gastroenterology, People's Hospital of Taizhou, Taizhou, Jiangsu 225300, P.R. China - Published online on: April 1, 2016 https://doi.org/10.3892/ol.2016.4401
- Pages: 3231-3239
This article is mentioned in:
Abstract
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI | |
Danaei G, Vander Hoorn S, Lopez AD, Murray CJ and Ezzati M: Comparative Risk Assessment collaborating group (Cancers): Causes of cancer in the world: Comparative risk assessment of nine behavioural and environmental risk factors. Lancet. 366:1784–1793. 2005. View Article : Google Scholar : PubMed/NCBI | |
Wang JB, Fan JH, Liang H, Li J, Xiao HJ, Wei WQ, Dawsey SM, Qiao YL and Boffetta P: Attributable causes of esophageal cancer incidence and mortality in China. PLoS One. 7:e422812012. View Article : Google Scholar : PubMed/NCBI | |
Engel LS, Chow WH, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, et al: Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst. 95:1404–1413. 2003. View Article : Google Scholar : PubMed/NCBI | |
Jones L, Bates G, McCoy E and Bellis MA: Relationship between alcohol-attributable disease and socioeconomic status, and the role of alcohol cons-umption in this relationship: A systematic review and meta-analysis. BMC Public Health. 15:4002015. View Article : Google Scholar : PubMed/NCBI | |
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Amann M, Anderson HR, Andrews KG, Aryee M, Atkinson C, et al: A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380:2224–2260. 2012. View Article : Google Scholar : PubMed/NCBI | |
Pöschl G and Seitz HK: Alcohol and cancer. Alcohol Alcohol. 39:155–165. 2004. View Article : Google Scholar : PubMed/NCBI | |
Brooks PJ and Theruvathu JA: DNA adducts from acetaldehyde: Implications for alcohol-related carcinogenesis. Alcohol. 35:187–193. 2005. View Article : Google Scholar : PubMed/NCBI | |
Seitz HK and Stickel F: Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 7:599–612. 2007. View Article : Google Scholar : PubMed/NCBI | |
Oze I, Matsuo K, Wakai K, Nagata C, Mizoue T, Tanaka K, Tsuji I, Sasazuki S, Inoue M and Tsugane S: Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan: Alcohol drinking and esophageal cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol. 41:677–692. 2011. View Article : Google Scholar : PubMed/NCBI | |
Islami F, Fedirko V, Tramacere I, Bagnardi V, Jenab M, Scotti L, Rota M, Corrao G, Garavello W, Schüz J, et al: Alcohol drinking and esophageal squamous cell carcinoma with focus on light-drinkers and never-smokers: A systematic review and meta-analysis. Int J Cancer. 129:2473–2484. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kumagai N, Wakai T, Akazawa K, Ling Y, Wang S, Shan B, Okuhara Y, Hatakeyama Y and Kataoka H: Heavy alcohol intake is a risk factor for esophageal squamous cell carcinoma among middle-aged men: A case-control and simulation study. Mol Clin Oncol. 1:811–816. 2013.PubMed/NCBI | |
Gao YT, McLaughlin JK, Blot WJ, Ji BT, Benichou J, Dai Q and Fraumeni JF Jr: Risk factors for esophageal cancer in Shanghai, China. I. Role of cigarette smoking and alcohol drinking. Int J Cancer. 58:192–196. 1994. View Article : Google Scholar : PubMed/NCBI | |
Zambon P, Talamini R, La Vecchia C, Dal Maso L, Negri E, Tognazzo S, Simonato L and Franceschi S: Smoking, type of alcoholic beverage and squamous-cell oesophageal cancer in northern Italy. Int J Cancer. 86:144–149. 2000. View Article : Google Scholar : PubMed/NCBI | |
Lubin JH, Cook MB, Pandeya N, Vaughan TL, Abnet CC, Giffen C, Webb PM, Murray LJ, Casson AG, Risch HA, et al: The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Cancer Epidemiol. 36:306–316. 2012. View Article : Google Scholar : PubMed/NCBI | |
Polesel J, Dal Maso L, Bagnardi V, Zucchetto A, Zambon A, Levi F, La Vecchia C and Franceschi S: Estimating dose-response relationship between ethanol and risk of cancer using regression spline models. Int J Cancer. 114:836–841. 2005. View Article : Google Scholar : PubMed/NCBI | |
Steevens J, Schouten LJ, Goldbohm RA and van den Brandt PA: Alcohol consumption, cigarette smoking and risk of subtypes of oesophageal and gastric cancer: A prospective cohort study. Gut. 59:39–48. 2010. View Article : Google Scholar : PubMed/NCBI | |
Fan Y, Yuan JM, Wang R, Gao YT and Yu MC: Alcohol, tobacco, and diet in relation to esophageal cancer: The Shanghai Cohort Study. Nutr Cancer. 60:354–363. 2008. View Article : Google Scholar : PubMed/NCBI | |
Castellsagué X, Muñoz N, De Stefani E, Victora CG, Castelletto R, Rolón PA and Quintana MJ: Independent and joint effects of tobacco smoking and alcohol drinking on the risk of esophageal cancer in men and women. Int J Cancer. 82:657–664. 1999. View Article : Google Scholar : PubMed/NCBI | |
Holmes RS and Vaughan TL: Epidemiology and pathogenesis of esophageal cancer. Semin Radiat Oncol. 17:2–9. 2007. View Article : Google Scholar : PubMed/NCBI | |
Linderborg K, Joly JP, Visapää JP and Salaspuro M: Potential mechanism for Calvados-related oesophageal cancer. Food Chem Toxicol. 46:476–479. 2008. View Article : Google Scholar : PubMed/NCBI | |
Bosetti C, La Vecchia C, Negri E and Franceschi S: Wine and other types of alcoholic beverages and the risk of esophageal cancer. Eur J Clin Nutr. 54:918–920. 2000. View Article : Google Scholar : PubMed/NCBI | |
Launoy G, Milan C, Day NE, Faivre J, Pienkowski P and Gignoux M: Oesophageal cancer in France: Potential importance of hot alcoholic drinks. Int J Cancer. 71:917–923. 1997. View Article : Google Scholar : PubMed/NCBI | |
Neuhouser ML: Dietary flavonoids and cancer risk: Evidence from human population studies. Nutr Cancer. 50:1–7. 2004. View Article : Google Scholar : PubMed/NCBI | |
Wu M, Zhao JK, Zhang ZF, Han RQ, Yang J, Zhou JY, Wang XS, Zhang XF, Liu AM, van't Veer P, et al: Smoking and alcohol drinking increased the risk of esophageal cancer among Chinese men but not women in a high-risk population. Cancer Causes Control. 22:649–657. 2011. View Article : Google Scholar : PubMed/NCBI | |
Vioque J, Barber X, Bolumar F, Porta M, Santibáñez M, de la Hera MG and Moreno-Osset E: PANESOES Study Group: Esophageal cancer risk by type of alcohol drinking and smoking: A case-control study in Spain. BMC Cancer. 8:2212008. View Article : Google Scholar : PubMed/NCBI | |
Wang Z, Tang L, Sun G, Tang Y, Xie Y, Wang S, Hu X, Gao W, Cox SB and Wang JS: Etiological study of esophageal squamous cell carcinoma in an endemic region: A population-based case control study in Huaian, China. BMC Cancer. 6:2872006. View Article : Google Scholar : PubMed/NCBI | |
Tran GD, Sun XD, Abnet CC, Fan JH, Dawsey SM, Dong ZW, Mark SD, Qiao YL and Taylor PR: Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer. 113:456–463. 2005. View Article : Google Scholar : PubMed/NCBI | |
Freedman ND, Murray LJ, Kamangar F, Abnet CC, Cook MB, Nyrén O, Ye W, Wu AH, Bernstein L, Brown LM, et al: Alcohol intake and risk of oesophageal adenocarcinoma: A pooled analysis from the BEACON Consortium. Gut. 60:1029–1037. 2011. View Article : Google Scholar : PubMed/NCBI | |
Steevens J, Schouten LJ, Driessen AL, Huysentruyt CJ, Keulemans YC, Goldbohm RA and van den Brandt PA: A prospective cohort study on overweight, smoking, alcohol consumption, and risk of Barrett's esophagus. Cancer Epidemiol Biomarkers Prev. 20:345–358. 2011. View Article : Google Scholar : PubMed/NCBI | |
Tramacere I, Pelucchi C, Bagnardi V, Rota M, Scotti L, Islami F, Corrao G, Boffetta P, La Vecchia C and Negri E: A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. Ann Oncol. 23:287–297. 2012. View Article : Google Scholar : PubMed/NCBI | |
Thrift AP, Kramer JR, Richardson PA and El-Serag HB: No significant effects of smoking or alcohol consumption on risk of Barrett's esophagus. Dig Dis Sci. 59:108–116. 2014. View Article : Google Scholar : PubMed/NCBI | |
Akiyama T, Inamori M, Iida H, Mawatari H, Endo H, Hosono K, Yoneda K, Fujita K, Yoneda M, Takahashi H, et al: Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men. BMC Gastroenterol. 8:582008. View Article : Google Scholar : PubMed/NCBI | |
Siewert JR and Ott K: Are squamous and adenocarcinomas of the esophagus the same disease? Semin Radiat Oncol. 17:38–44. 2007. View Article : Google Scholar : PubMed/NCBI | |
Druesne-Pecollo N, Tehard B, Mallet Y, Gerber M, Norat T, Hercberg S and Latino-Martel P: Alcohol and genetic polymorphisms: Effect on risk of alcohol-related cancer. Lancet Oncol. 10:173–180. 2009. View Article : Google Scholar : PubMed/NCBI | |
Edenberg HJ: The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health. 30:5–13. 2007.PubMed/NCBI | |
Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, Bouchardy C, Caporaso N, Chen C, Coutelle C, Diehl SR, et al: Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: A HuGE review. Am J Epidemiol. 159:1–16. 2004. View Article : Google Scholar : PubMed/NCBI | |
Boffetta P and Hashibe M: Alcohol and cancer. Lancet Oncol. 7:149–156. 2006. View Article : Google Scholar : PubMed/NCBI | |
Bosron WF and Li TK: Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology. 6:502–510. 1986. View Article : Google Scholar : PubMed/NCBI | |
Osier M, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, Edenberg HJ, Lu RB and Kidd KK: Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet. 64:1147–1157. 1999. View Article : Google Scholar : PubMed/NCBI | |
Yokoyama A, Kato H, Yokoyama T, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, et al: Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis. 23:1851–1859. 2002. View Article : Google Scholar : PubMed/NCBI | |
Zhang GH, Mai RQ and Huang B: Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China. World J Gastroenterol. 16:6020–6025. 2010.PubMed/NCBI | |
Lee CH, Lee JM, Wu DC, Goan YG, Chou SH, Wu IC, Kao EL, Chan TF, Huang MC, Chen PS, et al: Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. Int J Cancer. 122:1347–1356. 2008. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Ji R, Wei X, Gu L, Chen L, Rong Y, Wang R, Zhang Z, Liu B and Xia S: Esophageal squamous cell carcinoma and ALDH2 and ADH1B polymorphisms in Chinese females. Asian Pac J Cancer Prev. 12:2065–2068. 2011.PubMed/NCBI | |
Wu M, Chang SC, Kampman E, Yang J, Wang XS, Gu XP, Han RQ, Liu AM, Wallar G, Zhou JY, et al: Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: A population-based case-control study in China. Int J Cancer. 132:1868–1877. 2013. View Article : Google Scholar : PubMed/NCBI | |
Muto M, Nakane M, Hitomi Y, Yoshida S, Sasaki S, Ohtsu A, Yoshida S, Ebihara S and Esumi H: Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer. Carcinogenesis. 23:1759–1765. 2002. View Article : Google Scholar : PubMed/NCBI | |
Terry MB, Gammon MD, Zhang FF, Vaughan TL, Chow WH, Risch HA, Schoenberg JB, Mayne ST, Stanford JL, West AB, et al: Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas. Cancer Causes Control. 18:1039–1046. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Bencko V, Moullan N, et al: Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev. 15:696–703. 2006. View Article : Google Scholar : PubMed/NCBI | |
Jairam S and Edenberg HJ: An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7. Gene. 547:239–244. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Wei J, Xu X, Pan W, Ge Y, Zhou C, Liu C, Gao J, Yang M and Mao W: Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS. PLoS One. 9:e940962014. View Article : Google Scholar : PubMed/NCBI | |
Hashibe M, McKay JD, Curado MP, Oliveira JC, Koifman S, Koifman R, Zaridze D, Shangina O, Wünsch-Filho V, Eluf-Neto J, et al: Multiple ADH genes are associated with upper aerodigestive cancers. Nat Genet. 40:707–709. 2008. View Article : Google Scholar : PubMed/NCBI | |
Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, et al: Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. Cancer Epidemiol Biomarkers Prev. 18:3097–3102. 2009. View Article : Google Scholar : PubMed/NCBI | |
Li H, Borinskaya S, Yoshimura K, Kal'ina N, Marusin A, Stepanov VA, Qin Z, Khaliq S, Lee MY, Yang Y, et al: Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. Ann Hum Genet. 73:335–345. 2009. View Article : Google Scholar : PubMed/NCBI | |
Mizoi Y, Yamamoto K, Ueno Y, Fukunaga T and Harada S: Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol. 29:707–710. 1994.PubMed/NCBI | |
Yokoyama A, Muramatsu T, Ohmori T, Makuuchi H, Higuchi S, Matsushita S, Yoshino K, Maruyama K, Nakano M and Ishii H: Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics. Cancer. 77:1986–1990. 1996. View Article : Google Scholar : PubMed/NCBI | |
Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K and Ishii H: Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis. 19:1383–1387. 1998. View Article : Google Scholar : PubMed/NCBI | |
Lewis SJ and Smith GD: Alcohol, ALDH2, and esophageal cancer: A meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. Cancer Epidemiol Biomarkers Prev. 14:1967–1971. 2005. View Article : Google Scholar : PubMed/NCBI | |
Yokoyama T, Yokoyama A, Kato H, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, et al: Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer Epidemiol Biomarkers Prev. 12:1227–1233. 2003.PubMed/NCBI | |
Brooks PJ, Enoch MA, Goldman D, Li TK and Yokoyama A: The alcohol flushing response: An unrecognized risk factor for esophageal cancer from alcohol consumption. PLoS Med. 6:e502009. View Article : Google Scholar : PubMed/NCBI | |
Lewis DF, Bird MG and Parke DV: Molecular modelling of CYP2E1 enzymes from rat, mouse and man: An explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity. Toxicology. 118:93–113. 1997. View Article : Google Scholar : PubMed/NCBI | |
Gonzalez FJ: Role of cytochromes P450 in chemical toxicity and oxidative stress: Studies with CYP2E1. Mutat Res. 569:101–110. 2005. View Article : Google Scholar : PubMed/NCBI | |
Guo YM, Wang Q, Liu YZ, Chen HM, Qi Z and Guo QH: Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. World J Gastroenterol. 14:1444–1449. 2008. View Article : Google Scholar : PubMed/NCBI | |
Qin JM, Yang L, Chen B, Wang XM, Li F, Liao PH and He L: Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population. World J Gastroenterol. 14:6986–6992. 2008. View Article : Google Scholar : PubMed/NCBI | |
Morita S, Yano M, Shiozaki H, Tsujinaka T, Ebisui C, Morimoto T, Kishibuti M, Fujita J, Ogawa A, Taniguchi M, et al: CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus. Int J Cancer. 71:192–195. 1997. View Article : Google Scholar : PubMed/NCBI | |
Lucas D, Ménez C, Floch F, Gourlaouen Y, Sparfel O, Joannet I, Bodénez P, Jezequel J, Gouérou H, Berthou F, et al: Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic caucasians. Alcohol Clin Exp Res. 20:1033–1037. 1996. View Article : Google Scholar : PubMed/NCBI | |
Rossini A, Rapozo DC, Soares Lima SC, Guimarães DP, Ferreira MA, Teixeira R, Kruel CD, Barros SG, Andreollo NA, Acatauassú R, et al: Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Carcinogenesis. 28:2537–2542. 2007. View Article : Google Scholar : PubMed/NCBI | |
Dura P, Berkers T, van Veen EM, Salomon J, te Morsche RH, Roelofs HM, Kristinsson JO, Wobbes T, Witteman BJ, Tan AC, et al: Polymorphisms in alcohol-metabolizing enzymes and esophageal carcinoma susceptibility: A Dutch Caucasian case-control study. J Hum Genet. 58:742–748. 2013. View Article : Google Scholar : PubMed/NCBI | |
Trimmer EE: Methylenetetrahydrofolate reductase: Biochemical characterization and medical significance. Curr Pharm Des. 19:2574–2593. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ly A, Hoyt L, Crowell J and Kim YI: Folate and DNA methylation. Antioxid Redox Sign. 17:302–326. 2012. View Article : Google Scholar | |
Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA and van den Heuvel LP: A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet. 10:111–113. 1995. View Article : Google Scholar : PubMed/NCBI | |
Stern LL, Mason JB, Selhub J and Choi SW: Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev. 9:849–853. 2000.PubMed/NCBI | |
Goyette P, Sumner JS, Milos R, Duncan AM, Rosenblatt DS, Matthews RG and Rozen R: Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification. Nat Genet. 7:195–200. 1994. View Article : Google Scholar : PubMed/NCBI | |
Bailey LB and Gregory JF III: Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement. J Nutr. 129:919–922. 1999.PubMed/NCBI | |
Li QD, Li H, Wang MS, Diao TY, Zhou ZY, Fang QX, Yang FY and Li QH: Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County. BMC Gastroenterol. 11:742011. View Article : Google Scholar : PubMed/NCBI | |
Zhao P, Lin F, Li Z, Lin B, Lin J and Luo R: Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. Asian Pac J Cancer Prev. 12:2019–2023. 2011.PubMed/NCBI | |
Li D, Diao Y and Li H, Fang X and Li H: Association of the polymorphisms of MTHFR C677T, VDR C352T and MPO G463A with risk for esophageal squamous cell dysplasia and carcinoma. Arch Med Res. 39:594–600. 2008. View Article : Google Scholar : PubMed/NCBI | |
Langevin SM, Lin D, Matsuo K, Gao CM, Takezaki T, Stolzenberg-Solomon RZ, Vasavi M, Hasan Q and Taioli E: Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer. Toxicol Lett. 184:73–80. 2009. View Article : Google Scholar : PubMed/NCBI | |
Liu YX, Wang B, Wan MH, Tang WF, Huang FK and Li C: Meta-analysis of the relationship between the metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer. Asian Pac J Cancer Prev. 12:247–252. 2011.PubMed/NCBI | |
Yang CX, Matsuo K, Ito H, Shinoda M, Hatooka S, Hirose K, Wakai K, Saito T, Suzuki T, Maeda T and Tajima K: Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: Results of a case-control study in Japan. Carcinogenesis. 26:1285–1290. 2005. View Article : Google Scholar : PubMed/NCBI | |
Song C, Xing D, Tan W, Wei Q and Lin D: Methylene-tetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Res. 61:3272–3275. 2001.PubMed/NCBI | |
Hiyama T, Yoshihara M, Tanaka S and Chayama K: Genetic polymorphisms and esophageal cancer risk. Int J Cancer. 121:1643–1658. 2007. View Article : Google Scholar : PubMed/NCBI | |
Wang AH, Sun CS, Li LS, Huang JY, Chen QS and Xu DZ: Genetic susceptibility and environmental factors of esophageal cancer in Xi'an. World J Gastroenterol. 10:940–944. 2004.PubMed/NCBI | |
Li D, Dandara C and Parker MI: The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. BMC Genet. 11:472010. View Article : Google Scholar : PubMed/NCBI | |
Secretan B, Straif K, Baan R, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L and Cogliano V: WHO International Agency for Research on Cancer Monograph Working Group: A review of human carcinogens - Part E: Tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol. 10:1033–1034. 2009. View Article : Google Scholar : PubMed/NCBI | |
Littleton J, Barron S, Prendergast M and Nixon SJ: Smoking kills (alcoholics)! Shouldn't we do something about it? Alcohol Alcohol. 42:167–173. 2007. View Article : Google Scholar : PubMed/NCBI | |
Prabhu A, Obi KO and Rubenstein JH: The synergistic effects of alcohol and tobacco consumption on the risk of esophageal squamous cell carcinoma: A meta-analysis. Am J Gastroenterol. 109:822–827. 2014. View Article : Google Scholar : PubMed/NCBI | |
Yaegashi Y, Onoda T, Morioka S, Hashimoto T, Takeshita T, Sakata K and Tamakoshi A: Joint effects of smoking and alcohol drinking on esophageal cancer mortality in Japanese men: Findings from the Japan collaborative cohort study. Asian Pac J Cancer Prev. 15:1023–1029. 2014. View Article : Google Scholar : PubMed/NCBI | |
Chen J, Zhang N, Wakai T, Wei L, He Y, Kumagai N, Kitsu K, Wang S and Akazawa K: Effect of the interaction between the amount and duration of alcohol consumption and tobacco smoking on the risk of esophageal cancer: A case-control study. Exp Ther Med. 1:991–997. 2010.PubMed/NCBI | |
Yang G, Fan L, Tan J, Qi G, Zhang Y, Samet JM, Taylor CE, Becker K and Xu J: Smoking in China: Findings of the 1996 National Prevalence Survey. JAMA. 282:1247–1253. 1999. View Article : Google Scholar : PubMed/NCBI | |
Toh Y, Oki E, Ohgaki K, Sakamoto Y, Ito S, Egashira A, Saeki H, Kakeji Y, Morita M, Sakaguchi Y, et al: Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: Molecular mechanisms of carcinogenesis. Int J Clin Oncol. 15:135–144. 2010. View Article : Google Scholar : PubMed/NCBI | |
Lopes CF, de Angelis BB, Prudente HM, de Souza BV, Cardoso SV and de Azambuja Ribeiro RI: Concomitant consumption of marijuana, alcohol and tobacco in oral squamous cell carcinoma development and progression: Recent advances and challenges. Arch Oral Biol. 57:1026–1033. 2012. View Article : Google Scholar : PubMed/NCBI | |
Salaspuro M: Interactions of alcohol and tobacco in gastrointestinal cancer. J Gastroenterol Hepatol. 28:12522013. | |
Simanowski UA, Suter P, Stickel F, Maier H, Waldherr R, Smith D, Russell RM and Seitz HK: Esophageal epithelial hyperproliferation following long-term alcohol consumption in rats: Effects of age and salivary gland function. J Natl Cancer Inst. 85:2030–2033. 1993. View Article : Google Scholar : PubMed/NCBI | |
Maier H, Weidauer H, Zöller J, Seitz HK, Flentje M, Mall G and Born IA: Effect of chronic alcohol consumption on the morphology of the oral mucosa. Alcohol Clin Exp Res. 18:387–391. 1994. View Article : Google Scholar : PubMed/NCBI | |
Homann N, Kärkkäinen P, Koivisto T, Nosova T, Jokelainen K and Salaspuro M: Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst. 89:1692–1697. 1997. View Article : Google Scholar : PubMed/NCBI | |
Homann N, Jousimies-Somer H, Jokelainen K, Heine R and Salaspuro M: High acetaldehyde levels in saliva after ethanol consumption: Methodological aspects and pathogenetic implications. Carcinogenesis. 18:1739–1743. 1997. View Article : Google Scholar : PubMed/NCBI | |
Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C and Yokoyama T: Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. Int J Cancer. 121:1047–1054. 2007. View Article : Google Scholar : PubMed/NCBI | |
Maier H, Born IA, Veith S, Adler D and Seitz HK: The effect of chronic ethanol consumption on salivary gland morphology and function in the rat. Alcohol Clin Exp Res. 10:425–427. 1986. View Article : Google Scholar : PubMed/NCBI | |
Salaspuro MP: Acetaldehyde, microbes, and cancer of the digestive tract. Crit Rev Clin Lab Sci. 40:183–208. 2003. View Article : Google Scholar : PubMed/NCBI | |
Salaspuro V and Salaspuro M: Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva. Int J Cancer. 111:480–483. 2004. View Article : Google Scholar : PubMed/NCBI | |
Holmstrup P and Bessermann M: Clinical, therapeutic, and pathogenic aspects of chronic oral multifocal candidiasis. Oral Surg Oral Med Oral Pathol. 56:388–395. 1983. View Article : Google Scholar : PubMed/NCBI | |
Colman G, Beighton D, Chalk AJ and Wake S: Cigarette smoking and the microbial flora of the mouth. Aust Dent J. 21:111–118. 1976. View Article : Google Scholar : PubMed/NCBI | |
Verna L, Whysner J and Williams GM: N-nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther. 71:57–81. 1996. View Article : Google Scholar : PubMed/NCBI | |
Shapiro KB, Hotchkiss JH and Roe DA: Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans. Food Chem Toxicol. 29:751–755. 1991. View Article : Google Scholar : PubMed/NCBI | |
Ahn J, Chen CY and Hayes RB: Oral microbiome and oral and gastrointestinal cancer risk. Cancer Causes Control. 23:399–404. 2012. View Article : Google Scholar : PubMed/NCBI | |
Pavlova SI, Jin L, Gasparovich SR and Tao L: Multiple alcohol dehydrogenases but no functional acetaldehyde dehydrogenase causing excessive acetaldehyde production from ethanol by oral streptococci. Microbiology. 159:1437–1446. 2013. View Article : Google Scholar : PubMed/NCBI | |
Muto M, Hitomi Y, Ohtsu A, Shimada H, Kashiwase Y, Sasaki H, Yoshida S and Esumi H: Acetaldehyde production by non-pathogenic Neisseria in human oral microflora: Implications for carcinogenesis in upper aerodigestive tract. Int J Cancer. 88:342–350. 2000. View Article : Google Scholar : PubMed/NCBI | |
Väkeväinen S, Tillonen J, Blom M, Jousimies-Somer H and Salaspuro M: Acetaldehyde production and other ADH-related characteristics of aerobic bacteria isolated from hypochlorhydric human stomach. Alcohol Clin Exp Res. 25:421–426. 2001. View Article : Google Scholar : PubMed/NCBI | |
Homann N, Tillonen J, Meurman JH, Rintamäki H, Lindqvist C, Rautio M, Jousimies-Somer H and Salaspuro M: Increased salivary acetaldehyde levels in heavy drinkers and smokers: A microbiological approach to oral cavity cancer. Carcinogenesis. 21:663–668. 2000. View Article : Google Scholar : PubMed/NCBI | |
Homann N, Tillonen J, Rintamäki H, Salaspuro M, Lindqvist C and Meurman JH: Poor dental status increases acetaldehyde production from ethanol in saliva: A possible link to increased oral cancer risk among heavy drinkers. Oral Oncol. 37:153–158. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tillonen J, Homann N, Rautio M, Jousimies-Somer H and Salaspuro M: Role of yeasts in the salivary acetaldehyde production from ethanol among risk groups for ethanol-associated oral cavity cancer. Alcohol Clin Exp Res. 23:1409–1415. 1999. View Article : Google Scholar : PubMed/NCBI | |
Tang L, Lee AH, Xu F, Zhang T, Lei J and Binns CW: Fruit and vegetable consumption and risk of esophageal cancer: A case-control study in north-west China. Dis Esophagus. 27:777–782. 2014. View Article : Google Scholar : PubMed/NCBI | |
Jeurnink SM, Büchner FL, Bueno-de-Mesquita HB, Siersema PD, Boshuizen HC, Numans ME, Dahm CC, Overvad K, Tjønneland A, Roswall N, et al: Variety in vegetable and fruit consumption and the risk of gastric and esophageal cancer in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 131:E963–E973. 2012. View Article : Google Scholar : PubMed/NCBI | |
Lucenteforte E, Garavello W, Bosetti C, Talamini R, Zambon P, Franceschi S, Negri E and La Vecchia C: Diet diversity and the risk of squamous cell esophageal cancer. Int J Cancer. 123:2397–2400. 2008. View Article : Google Scholar : PubMed/NCBI | |
Freedman ND, Park Y, Subar AF, Hollenbeck AR, Leitzmann MF, Schatzkin A and Abnet CC: Fruit and vegetable intake and esophageal cancer in a large prospective cohort study. Int J Cancer. 121:2753–2760. 2007. View Article : Google Scholar : PubMed/NCBI | |
Choi SW and Mason JB: Folate and carcinogenesis: An integrated scheme. J Nutr. 130:129–132. 2000.PubMed/NCBI | |
Larsson SC, Giovannucci E and Wolk A: Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: A meta-analysis. Gastroenterology. 131:1271–1283. 2006. View Article : Google Scholar : PubMed/NCBI | |
Tio M, Andrici J, Cox MR and Eslick GD: Folate intake and the risk of upper gastrointestinal cancers: A systematic review and meta-analysis. J Gastroenterol Hepatol. 29:250–258. 2014. View Article : Google Scholar : PubMed/NCBI | |
Xiao Q, Freedman ND, Ren J, Hollenbeck AR, Abnet CC and Park Y: Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study. Br J Cancer. 110:1328–1333. 2014. View Article : Google Scholar : PubMed/NCBI | |
Ulrich CM: Folate and cancer prevention: A closer look at a complex picture. Am J Clin Nutr. 86:271–273. 2007.PubMed/NCBI | |
Ibiebele TI, Hughes MC, Pandeya N, Zhao Z, Montgomery G, Hayward N, Green AC, Whiteman DC and Webb PM: Study of Digestive Health; Australian Cancer Study: High intake of folate from food sources is associated with reduced risk of esophageal cancer in an Australian population. J Nutr. 141:274–283. 2011. View Article : Google Scholar : PubMed/NCBI | |
Matsuo K, Rossi M, Negri E, Oze I, Hosono S, Ito H, Watanabe M, Yatabe Y, Hasegawa Y, Tanaka H, et al: Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese. Eur J Cancer Prev. 21:193–198. 2012. View Article : Google Scholar : PubMed/NCBI | |
Shanmugham JR, Zavras AI, Rosner BA and Giovannucci EL: Alcohol-folate interactions in the risk of oral cancer in women: A prospective cohort study. Cancer Epidemiol Biomarkers Prev. 19:2516–2524. 2010. View Article : Google Scholar : PubMed/NCBI | |
Halsted CH, Villanueva JA, Devlin AM and Chandler CJ: Metabolic interactions of alcohol and folate. J Nutr. 132(Suppl 8): 2367S–2372S. 2002.PubMed/NCBI | |
Hamid A, Wani NA and Kaur J: New perspectives on folate transport in relation to alcoholism-induced folate malabsorption - association with epigenome stability and cancer development. FEBS J. 276:2175–2191. 2009. View Article : Google Scholar : PubMed/NCBI | |
Biswas A, Senthilkumar SR and Said HM: Effect of chronic alcohol exposure on folate uptake by liver mitochondria. Am J Physiol Cell Physiol. 302:C203–C209. 2012. View Article : Google Scholar : PubMed/NCBI | |
Wani NA, Hamid A and Kaur J: Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes. Mol Cell Biochem. 363:157–166. 2012. View Article : Google Scholar : PubMed/NCBI | |
Said HM, Mee L, Sekar VT, Ashokkumar B and Pandol SJ: Mechanism and regulation of folate uptake by pancreatic acinar cells: Effect of chronic alcohol consumption. Am J Physiol Gastrointest Liver Physiol. 298:G985–G993. 2010. View Article : Google Scholar : PubMed/NCBI | |
Wani NA, Nada R, Khanduja KL and Kaur J: Decreased activity of folate transporters in lipid rafts resulted in reduced hepatic folate uptake in chronic alcoholism in rats. Genes Nutr. 8:209–219. 2013. View Article : Google Scholar : PubMed/NCBI | |
Mason JB and Choi SW: Effects of alcohol on folate metabolism: Implications for carcinogenesis. Alcohol. 35:235–241. 2005. View Article : Google Scholar : PubMed/NCBI |