Isolated brain metastasis as a late recurrence of completely resected non-small cell lung cancer

Ju ,Lixia; Han,Mingquan

doi:10.3892/ol.2016.4674

Isolated brain metastasis as a late recurrence of completely resected non-small cell lung cancer

Authors:
- Lixia Ju
- Mingquan Han
View Affiliations

Affiliations: Department of Integrative Medicine, Tongji University School of Medicine, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai 200092, P.R. China
Published online on: June 1, 2016 https://doi.org/10.3892/ol.2016.4674
Pages: 731-733

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The brain is one of the most common sites for non-small cell lung cancer (NSCLC) metastasis; however, late isolated brain metastasis as a recurrence of NSCLC is rare. The present study describes a case of isolated solitary brain metastasis as a late recurrence of NSCLC, which occurred >2 years following the successful resection of the primary tumor, and was identified by magnetic resonance imaging. To the best of our knowledge, this is the first report of isolated brain metastasis as a postoperative recurrence of NSCLC. The aim of the present study was to highlight that, despite its rarity, such recurrence should be considered possible, and particular attention to the treatment of such patients should be paid.

View Figures

View References

1	Schouten LJ, Rutten J, Huveneers HA and Twijnstra A: Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer. 94:2698–2705. 2002. View Article : Google Scholar : PubMed/NCBI
2	Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS and Young B: A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 322:494–500. 1990. View Article : Google Scholar : PubMed/NCBI
3	Nakade M, Kohno K and Watanabe H: Treatment strategies for lung cancer brain metastases. Nihon Kyobu Geka Gakkai Zasshi. 45:1911–1915. 1997.(In Japanese). PubMed/NCBI
4	Wroński M, Arbit E, Burt M and Galicich JH: Survival after surgical treatment of brain metastases from lung cancer: A follow-up study of 231 patients treated between 1976 and 1991. J Neurosurg. 83:605–616. 1995. View Article : Google Scholar : PubMed/NCBI
5	Sørensen JB, Hansen HH, Hansen M and Dombernowsky P: Brain metastases in adenocarcinoma of the lung: Frequency, risk groups, and prognosis. J Clin Oncol. 6:1474–1480. 1988.PubMed/NCBI
6	Martini N, Bains MS, Burt ME, Zakowski MF, McCormack P, Rusch VW and Ginsberg RJ: Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J Thorac Cardiovasc Surg. 109:120–129. 1995. View Article : Google Scholar : PubMed/NCBI
7	al-Kattan K, Sepsas E, Fountain SW and Townsend ER: Disease recurrence after resection for stage I lung cancer. Eur J Cardiothorac Surg. 12:380–384. 1997. View Article : Google Scholar : PubMed/NCBI
8	Yoshino I, Yohena T, Kitajima M, Ushijima C, Nishioka K, Ichinose Y and Sugimachi K: Survival of non-small cell lung cancer patients with postoperative recurrence at distant organs. Ann Thorac Cardiovasc Surg. 7:204–209. 2001.PubMed/NCBI
9	Martin J, Ginsberg RJ, Venkatraman ES, Bains MS, Downey RJ, Korst RJ, Kris MG and Rusch VW: Long-term results of combined-modality therapy in resectable non-small-cell lung cancer. J Clin Oncol. 20:1989–1995. 2002. View Article : Google Scholar : PubMed/NCBI
10	Sasaki H, Suzuki A, Tatematsu T, Shitara M, Hikosaka Y, Okuda K, Moriyama S, Yano M and Fujii Y: Prognosis of recurrent non-small cell lung cancer following complete resection. Oncol Lett. 7:1300–1304. 2014.PubMed/NCBI
11	Hiyoshi Y, Yoshida N, Watanabe M, Kurashige J, Karashima R, Iwagami S, Baba Y and Baba H: Late recurrence after radical resection of esophageal cancer. World J Surg. Nov 9–2015.(Epub ahead of print). PubMed/NCBI
12	Kang WM, Meng QB, Yu JC, Ma ZQ and Li ZT: Factors associated with early recurrence after curative surgery for gastric cancer. World J Gastroenterol. 21:5934–5940. 2015.PubMed/NCBI
13	Quan AL, Videtic GM and Suh JH: Brain metastases in small cell lung cancer. Oncology (Williston Park). 18:961–972; discussion 974, 979–80, 987. 2004.PubMed/NCBI
14	On NH, Mitchell R, Savant SD, Bachmeier CJ, Hatch GM and Miller DW: Examination of blood-brain barrier (BBB) integrity in a mouse brain tumor model. J Neurooncol. 111:133–143. 2013. View Article : Google Scholar : PubMed/NCBI
15	Sundström JT, Minn H, Lertola KK and Nordman E: Prognosis of patients treated for intracranial metastases with whole-brain irradiation. Ann Med. 30:296–299. 1998. View Article : Google Scholar : PubMed/NCBI
16	Sperduto PW: What is your patient's GPA and why does it matter? Managing brain metastases and the cost of hope. Int J Radiat Oncol Biol Phys. 77:643–644. 2010. View Article : Google Scholar : PubMed/NCBI
17	Zabel A and Debus J: Treatment of brain metastases from non-small-cell lung cancer (NSCLC): Radiotherapy. Lung Cancer. 45(Suppl 2): S247–S252. 2004. View Article : Google Scholar : PubMed/NCBI
18	Yokouchi H, Miyazaki M, Miyamoto T, Tsuji F, Ebisui C and Murata K: Post-recurrence survival after surgical resection of non-small cell lung cancer with local recurrence. Gan To Kagaku Ryoho. 41:2050–2052. 2014.(In Japanese). PubMed/NCBI
19	Williams BA, Sugimura H, Endo C, Nichols FC, Cassivi SD, Allen MS, Pairolero PC, Deschamps C and Yang P: Predicting postrecurrence survival among completely resected nonsmall-cell lung cancer patients. Ann Thorac Surg. 81:1021–1027. 2006. View Article : Google Scholar : PubMed/NCBI
20	Sugimura H, Nichols FC, Yang P, Allen MS, Cassivi SD, Deschamps C, Williams BA and Pairolero PC: Survival after recurrent nonsmall-cell lung cancer after complete pulmonary resection. Ann Thorac Surg. 83:409–418. 2007. View Article : Google Scholar : PubMed/NCBI
21	Hung JJ, Hsu WH, Hsieh CC, Huang BS, Huang MH, Liu JS and Wu YC: Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence. Thorax. 64:192–196. 2009. View Article : Google Scholar : PubMed/NCBI
22	Shimada Y, Saji H, Yoshida K, Kakihana M, Honda H, Nomura M, Usuda J, Kajiwara N, Ohira T and Ikeda N: Prognostic factors and the significance of treatment after recurrence in completely resected stage I non-small cell lung cancer. Chest. 143:1626–1634. 2013. View Article : Google Scholar : PubMed/NCBI
23	Maeda R, Yoshida J, Ishii G, Aokage K, Hishida T, Nishimura M, Nishiwaki Y and Nagai K: Long-term outcome and late recurrence in patients with completely resected stage IA non-small cell lung cancer. J Thorac Oncol. 5:1246–1250. 2010. View Article : Google Scholar : PubMed/NCBI
24	Luketich JD, Martini N, Ginsberg RJ, Rigberg D and Burt ME: Successful treatment of solitary extracranial metastases from non-small cell lung cancer. Ann Thorac Surg. 60:1609–1611. 1995. View Article : Google Scholar : PubMed/NCBI
25	Shahidi H and Kvale PA: Long-term survival following surgical treatment of solitary brain metastasis in non-small cell lung cancer. Chest. 109:271–276. 1996. View Article : Google Scholar : PubMed/NCBI
26	Kagohashi K, Satoh H, Yamashita YT and Sekizawa K: Brain metastasis as the first manifestation of lung cancer. Am J Med. 114:4202003. View Article : Google Scholar : PubMed/NCBI