Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma

  • Authors:
    • Tian‑Yun Shen
    • Li‑Li Mei
    • Yun‑Tan Qiu
    • Zhi‑Zhou Shi
  • View Affiliations

  • Published online on: August 3, 2016     https://doi.org/10.3892/ol.2016.4947
  • Pages: 2956-2961
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Abstract

The aim of the present study was to identify the candidate target genes of genomic aberrations in esophageal squamous cell carcinoma (ESCC). Array comparative genomic hybridization (CGH) and quantitative polymerase chain reaction were applied to analyze the copy number changes and expression level of candidate genes, respectively. Integrative analysis revealed that homozygous deletions of cyclin‑dependent kinase inhibitor (CDKN) 2A and CDKN2B and gains of fascin actin‑bundling protein 1 (FSCN1) and homer scaffolding protein 3 (HOMER3) occurred frequently in ESCC. The results demonstrated that the homozygous deletion of CDKN2A or CDKN2B was significantly associated with lymph node metastasis. Notably, the expression of CDKN2A and CDKN2B was lower in dysplasia than in normal esophageal epithelium. We also observed that the copy number increase of FSCN1 was significantly associated with pT, pN and pStage, and that the gain of HOMER3 was significantly linked with pN and pStage. We further revealed that FSCN1 and HOMER3 were overexpressed in ESCC, and that their overexpression was correlated with copy number increase. In conclusion, CDKN2A, CDKN2B, FSCN1 and HOMER3 are candidate cancer‑associated genes and may play a tumorigenic role in ESCC.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shen TY, Mei LL, Qiu YT and Shi ZZ: Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma. Oncol Lett 12: 2956-2961, 2016.
APA
Shen, T., Mei, L., Qiu, Y., & Shi, Z. (2016). Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma. Oncology Letters, 12, 2956-2961. https://doi.org/10.3892/ol.2016.4947
MLA
Shen, T., Mei, L., Qiu, Y., Shi, Z."Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma". Oncology Letters 12.4 (2016): 2956-2961.
Chicago
Shen, T., Mei, L., Qiu, Y., Shi, Z."Identification of candidate target genes of genomic aberrations in esophageal squamous cell carcinoma". Oncology Letters 12, no. 4 (2016): 2956-2961. https://doi.org/10.3892/ol.2016.4947