Open Access

Why man's best friend, the dog, could also benefit from an anti‑HER-2 vaccine (Review)

  • Authors:
    • Judit Fazekas
    • Irene Fürdös
    • Josef Singer
    • Erika Jensen‑Jarolim
  • View Affiliations

  • Published online on: August 11, 2016     https://doi.org/10.3892/ol.2016.5001
  • Pages: 2271-2276
  • Copyright: © Fazekas et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human epidermal growth factor receptor‑2 (HER‑2) is a well‑established target for anticancer precision medicine in humans. A HER‑2 homologue with 92% amino acid identity has been described in canine mammary tumors, which is termed here as ‘dog epidermal growth factor receptor‑2 (DER‑2)’, with similar biological implications as those in human breast cancer. Both antigens can principally be immunologically targeted by anti-HER-2 antibodies, such as trastuzumab; however, the in vivo application of humanized antibodies to other species would lead to specific hypersensitivity reactions. Therefore, HER‑2 mimotope vaccines that actively induce autologous trastuzumab‑like immunoglobulins represent a novel and economic treatment option to overcome species‑specific limitations. Thus, the present review proposes the implementation of clinical trials with HER‑2 vaccines in canine cancer model patients with spontaneous DER‑2 positive mammary gland carcinomas in order to assess their safety and efficacy. This approach would not only pave the way into the veterinary oncology market, but would also similarly generate robust data for human trials and facilitate the testing of novel combinatorial treatments.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fazekas J, Fürdös I, Singer J and Jensen‑Jarolim E: Why man's best friend, the dog, could also benefit from an anti‑HER-2 vaccine (Review). Oncol Lett 12: 2271-2276, 2016.
APA
Fazekas, J., Fürdös, I., Singer, J., & Jensen‑Jarolim, E. (2016). Why man's best friend, the dog, could also benefit from an anti‑HER-2 vaccine (Review). Oncology Letters, 12, 2271-2276. https://doi.org/10.3892/ol.2016.5001
MLA
Fazekas, J., Fürdös, I., Singer, J., Jensen‑Jarolim, E."Why man's best friend, the dog, could also benefit from an anti‑HER-2 vaccine (Review)". Oncology Letters 12.4 (2016): 2271-2276.
Chicago
Fazekas, J., Fürdös, I., Singer, J., Jensen‑Jarolim, E."Why man's best friend, the dog, could also benefit from an anti‑HER-2 vaccine (Review)". Oncology Letters 12, no. 4 (2016): 2271-2276. https://doi.org/10.3892/ol.2016.5001