Misdiagnosed infantile rhabdomyofibrosarcoma: A case report
- Authors:
- Tao Pan
- Ken Chen
- Run‑Song Jiang
- Zheng‑Yan Zhao
-
View Affiliations
Affiliations: Department of General Surgery, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China, Department of Reconstructive Plastic Surgery, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
- Published online on: August 17, 2016 https://doi.org/10.3892/ol.2016.5032
-
Pages:
2766-2768
Metrics:
Total
Views: 0 (Spandidos Publications: | PMC Statistics:
)
Metrics:
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics:
)
This article is mentioned in:
Abstract
Infantile rhabdomyofibrosarcoma is a rare form of soft-tissue tumor often associated with difficulties in diagnosis. The disease is positioned intermediately between rhabdomyosarcoma and infantile fibrosarcoma in terms of clinical presentation, immunohistochemistry, behavior, morphology and ultrastructural features. Reports of rhabdomyofibrosarcoma cases are limited in the literature. The present case describes a 26‑month‑old female who presented with a slowly progressive, soft‑tissue mass in the right chest wall. The mass was successfully treated with surgery. Using histopathology, the tumor was diagnosed and classified as infantile rhabdomyofibrosarcoma. The patient has been followed‑up for 2 years and is currently in good condition. The present case demonstrates that early, radical, local surgery and multidisciplinary cooperation were successful for the treatment of rhabdomyofibrosarcoma, and close follow‑up highly recommended.
View References
1
|
Gupta A, Maddalozzo J, Win Htin T, Shah A
and Chou PM: Spindle cell rhabdomyosarcoma of the tongue in an
infant: A case report with emphasis on differential diagnosis of
childhood spindle cell lesions. Pathol Res Pract. 200:537–543.
2004. View Article : Google Scholar : PubMed/NCBI
|
2
|
Rao SI, Uppin SG, Ratnakar KS, Sundaram C
and Senthil RP: Infantile rhabdomyofibrosarcoma: A distinct variant
or a missinglink between fibrosarcoma and rhabdomyosarcoma? Indian
J Cancer. 43:39–42. 2006. View Article : Google Scholar : PubMed/NCBI
|
3
|
Lundgren L, Angervall L, Stenman G and
Kindblom LG: Infantile rhabdomyofibrosarcoma: A high-grade sarcoma
distinguishable from infantile fibrosarcoma and rhabdomyosarcoma.
Hum Pathol. 24:785–795. 1993. View Article : Google Scholar : PubMed/NCBI
|
4
|
Weiss SW and Goldglum JR:
RhabdomyosarcomaSoft Tissue Tumors. Enzinger FM and Weiss SW: 4th.
1st. Mosby Inc.; Maryland Heights, MO: pp. 785–835. 2001
|
5
|
Miki H, Kobayashi S, Kushida Y, Sasaki M,
Haba R, Hirakawa E, Ogura K and Ohmori M: A case of infantile
rhabdomyofibrosarcoma with immunohistochemical,
electronmicroscopical, and genetic analyses. Hum Pathol.
30:1519–1522. 1999. View Article : Google Scholar : PubMed/NCBI
|
6
|
Chaudhary N, Shet T and Borker A:
Infantile rhabdomyofibrosarcoma: A potentially underdiagnosed
aggressive tumor. Int J Appl Basic Med Res. 3:66–68. 2013.
View Article : Google Scholar : PubMed/NCBI
|
7
|
Kumar S, Perlman S, Harris CA, Raffeld M
and Tsokos M: Myogenin is a specific marker for rhabdomyosarcomas:
An imunohistochemical study in paraffin-embedded tissues. Mod
Pathol. 13:988–993. 2000. View Article : Google Scholar : PubMed/NCBI
|
8
|
Tang HF, Wang TL, Gu WZ, Lin L and Li MJ:
Infantile rhabdomyofibrosarcoma. Zhonghua Bing Li Xue Za Zhi.
34:607–608. 2005.(In Chinese). PubMed/NCBI
|
9
|
Cessna MH, Zhou H, Perkins SL, Tripp SR,
Layfield L, Daines C and Coffin CM: Are myogenin and myo-D1
expression specific for rhabdomyosarcoma? A study of 150 cases with
emphasis on spindle cell mimics. Am J Surg Pathol. 25:1150–1157.
2001. View Article : Google Scholar : PubMed/NCBI
|