Open Access

A subpopulation of cancer stem cells identifies radiographic characteristics in glioblastoma

  • Authors:
    • Ja Eun Kim
    • Sung Kwon Kim
    • Jaekyung Shin
    • Young‑Bem Se
    • Seung Hong Choi
    • Sung‑Hye Park
    • Seung Ah Choi
    • Ji Yeoun Lee
    • Ji Hoon Phi
    • Kyu‑Chang Wang
    • Chul‑Kee Park
    • Seung‑Ki Kim
  • View Affiliations

  • Published online on: December 28, 2016     https://doi.org/10.3892/ol.2016.5548
  • Pages: 1175-1182
  • Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cancer stem cells (CSCs), defined by CD133 expression, harbor heterogeneous subpopulations of cells, including endothelial progenitor cells (EPCs). This study aimed to investigate whether a subpopulation of CSCs could affect the radiographic characteristics of glioblastoma. Tissue samples from 10 patients newly diagnosed with glioblastoma were selected according to the radiographic characteristics of their tumors. The patients were divided into two groups based on preoperative magnetic resonance imaging demonstrating contrast enhancement, necrosis and infiltrative patterns: the enhancement/necrosis group (E/N, n=5) and the non‑enhancement/infiltration group (NE/I, n=5). Flow cytometry was used to assess the CSCs while immunohistochemistry was used to study microvessel density and the proliferation index. The EPC (CD34+/CD133+) fraction in CSCs (CD133+) was larger in the NE/I group. However, there was little difference in the angiogenic activity assessed using microvessel density between the two groups. The proliferation index (assessed using the antibody Ki‑67) was higher in the E/N group and was negatively correlated with the EPC fraction. The non‑EPC (CD34‑/CD133+) fraction is a major factor responsible for radiographic characteristics of contrast enhancement, thus establishing an association between a subpopulation fraction of CSCs and radiographic characteristics in glioblastoma. Therefore, the simple non‑invasive assessment of studying contrast enhancement lesions in glioblastomas may be used to estimate CSC subpopulations.
View Figures
View References

Related Articles

Journal Cover

March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kim JE, Kim SK, Shin J, Se YB, Choi SH, Park SH, Choi SA, Lee JY, Phi JH, Wang KC, Wang KC, et al: A subpopulation of cancer stem cells identifies radiographic characteristics in glioblastoma. Oncol Lett 13: 1175-1182, 2017
APA
Kim, J.E., Kim, S.K., Shin, J., Se, Y., Choi, S.H., Park, S. ... Kim, S. (2017). A subpopulation of cancer stem cells identifies radiographic characteristics in glioblastoma. Oncology Letters, 13, 1175-1182. https://doi.org/10.3892/ol.2016.5548
MLA
Kim, J. E., Kim, S. K., Shin, J., Se, Y., Choi, S. H., Park, S., Choi, S. A., Lee, J. Y., Phi, J. H., Wang, K., Park, C., Kim, S."A subpopulation of cancer stem cells identifies radiographic characteristics in glioblastoma". Oncology Letters 13.3 (2017): 1175-1182.
Chicago
Kim, J. E., Kim, S. K., Shin, J., Se, Y., Choi, S. H., Park, S., Choi, S. A., Lee, J. Y., Phi, J. H., Wang, K., Park, C., Kim, S."A subpopulation of cancer stem cells identifies radiographic characteristics in glioblastoma". Oncology Letters 13, no. 3 (2017): 1175-1182. https://doi.org/10.3892/ol.2016.5548