Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation in vitro

  • Authors:
    • Shun‑Yao Ko
    • Hshin‑An Ko
    • Tzong‑Ming Shieh
    • Tzong‑Cherng Chi
    • Hong‑I Chen
    • Yi‑Ting Chen
    • Ya‑Hui Yu
    • Shu‑Han Yang
    • Shu‑Shing Chang
  • View Affiliations

  • Published online on: March 6, 2017     https://doi.org/10.3892/ol.2017.5809
  • Pages: 3328-3334
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Abstract

An irreversible non-enzymatic reaction between carbohydrates and proteins results in the formation of advanced glycation end products (AGEs). AGEs have been demonstrated to be a risk factor of complications in patients with diabetes mellitus (DM). Previous studies have suggested that patients with DM exhibit a higher rate of metastasis of oral cancer and a lower cancer‑associated survival rate. The receptor for AGEs (RAGE) has been associated with angiogenesis and an increase in cancer malignancy. Previous studies have suggested that AGE‑RAGE regulates cell migration via extracellular signal‑regulated kinase (ERK) phosphorylation. Nuclear factor-erythroid 2-related factor 2 (Nrf-2) is associated with the regulation of tumor protein p53 (p53) and the apoptotic response of oral cancer cells. AGEs are associated with oral cancer; however, the mechanism underlying this association remains to be elucidated. The present study hypothesized that AGEs regulate Nrf‑2 and downstream pathways through ERK phosphorylation. The results of the current study demonstrated that AGEs inhibit the expression of Nrf‑2, p53 and Bcl‑2 associated x apoptosis regulator, and increase the expression of apoptosis regulator Bcl‑x protein. The effect of AGEs was inhibited through the use of the PD98059. The present study demonstrated that AGEs regulate the downstream pathways Nrf-2 and Bcl-xl via ERK phosphorylation. It is suggested that AGEs regulate the survival of oral cancer cells via Nrf‑2 and Bcl‑xl through p53 regulation, which explains the poor prognosis of patients with DM who have oral cancer.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ko SY, Ko HA, Shieh TM, Chi TC, Chen HI, Chen YT, Yu YH, Yang SH and Chang SS: Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation in vitro. Oncol Lett 13: 3328-3334, 2017
APA
Ko, S., Ko, H., Shieh, T., Chi, T., Chen, H., Chen, Y. ... Chang, S. (2017). Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation in vitro. Oncology Letters, 13, 3328-3334. https://doi.org/10.3892/ol.2017.5809
MLA
Ko, S., Ko, H., Shieh, T., Chi, T., Chen, H., Chen, Y., Yu, Y., Yang, S., Chang, S."Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation in vitro". Oncology Letters 13.5 (2017): 3328-3334.
Chicago
Ko, S., Ko, H., Shieh, T., Chi, T., Chen, H., Chen, Y., Yu, Y., Yang, S., Chang, S."Advanced glycation end products influence oral cancer cell survival via Bcl-xl and Nrf-2 regulation in vitro". Oncology Letters 13, no. 5 (2017): 3328-3334. https://doi.org/10.3892/ol.2017.5809