Recombinant fibromodulin and decorin effects on NF-κB and TGFβ1 in the 4T1 breast cancer cell line

  • Authors:
    • Ladan Dawoody Nejad
    • Alireza Biglari
    • Tiziana Annese
    • Domenico Ribatti
  • View Affiliations

  • Published online on: March 31, 2017     https://doi.org/10.3892/ol.2017.5960
  • Pages: 4475-4480
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Constitutive activation of nuclear factor‑κB (NF‑κB) stimulates cell proliferation and metastasis, and inhibits apoptosis in breast cancer. Transforming growth factor-β (TGF-β) signaling pathway is deregulated in breast cancer progression and metastasis. The aim of the present study was to investigate the inhibitory effects of the two small leucine rich proteoglycans fibromodulin (Fmod) and decorin (Dcn), overexpressed using adenovirus gene transfer, on NF‑κB‑activity and TGF‑β1‑expression in the highly metastatic 4T1 breast cancer cell line. The results demonstrate that Fmod and Dcn overexpression is associated with NF‑κB and TGF‑β1 downregulation, and that Fmod promotes this effect more effectively compared with Dcn.
View Figures
View References

Related Articles

Journal Cover

June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Dawoody Nejad L , Biglari A, Annese T and Ribatti D: Recombinant fibromodulin and decorin effects on NF-κB and TGFβ1 in the 4T1 breast cancer cell line. Oncol Lett 13: 4475-4480, 2017
APA
Dawoody Nejad, L. ., Biglari, A., Annese, T., & Ribatti, D. (2017). Recombinant fibromodulin and decorin effects on NF-κB and TGFβ1 in the 4T1 breast cancer cell line. Oncology Letters, 13, 4475-4480. https://doi.org/10.3892/ol.2017.5960
MLA
Dawoody Nejad, L. ., Biglari, A., Annese, T., Ribatti, D."Recombinant fibromodulin and decorin effects on NF-κB and TGFβ1 in the 4T1 breast cancer cell line". Oncology Letters 13.6 (2017): 4475-4480.
Chicago
Dawoody Nejad, L. ., Biglari, A., Annese, T., Ribatti, D."Recombinant fibromodulin and decorin effects on NF-κB and TGFβ1 in the 4T1 breast cancer cell line". Oncology Letters 13, no. 6 (2017): 4475-4480. https://doi.org/10.3892/ol.2017.5960