Histological evaluations of primary lesions are independently associated with prognosis in patients with gastric cancer who receive neoadjuvant chemotherapy

  • Authors:
    • Tomomitsu Tahara
    • Tomoyuki Shibata
    • Masaaki Okubo
    • Dai Yoshida
    • Tomohiko Kawamura
    • Noriyuki Horiguchi
    • Takamitsu Ishizuka
    • Mitsuo Nagasaka
    • Yoshihito Nakagawa
    • Naoki Ohmiya
  • View Affiliations

  • Published online on: April 18, 2017     https://doi.org/10.3892/ol.2017.6040
  • Pages: 4892-4896
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Abstract

Neoadjuvant chemotherapy may improve outcomes for patients with locally advanced gastric cancer (GC). To explore useful predictive factors for the response of advanced GC to neoadjuvant chemotherapy, tumor responses were assessed using computed tomography (CT) with histological based criteria. A total of 78 patients with advanced GC undergoing neoadjuvant chemotherapy were included. CT‑based response assessment was performed following 2 courses of treatment. Histological evaluation of resected specimens was also performed according to the Japanese classification of gastric carcinoma. Grade 1b, 2 and 3 (viable tumor cells remaining in <2/3 of the tumorous area) were defined as histological responders. The results were associated with overall survival (OS) and progression‑free survival (PFS). The majority of the cases underwent tegafur/gimeracil/oteracil based preoperative chemotherapy as the first line of treatment (n=76, 96%). A total of 25 (32%) and 29 (37%) cases were considered to be CT and histological responders, respectively. CT-based evaluation was not associated with OS or PFS, while histological evaluation was significantly associated with OS and PFS. Histological based evaluation was not associated with CT and GI X‑ray or endoscopy‑based evaluation of primary lesions. Multivariate survival analysis using Cox's regression model demonstrated that histological non‑response was an independent prognostic factor for predicting worse OS. Histological-based evaluation of primary lesions was independently associated with prognosis in patients with GC who underwent neoadjuvant chemotherapy.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tahara T, Shibata T, Okubo M, Yoshida D, Kawamura T, Horiguchi N, Ishizuka T, Nagasaka M, Nakagawa Y, Ohmiya N, Ohmiya N, et al: Histological evaluations of primary lesions are independently associated with prognosis in patients with gastric cancer who receive neoadjuvant chemotherapy. Oncol Lett 13: 4892-4896, 2017
APA
Tahara, T., Shibata, T., Okubo, M., Yoshida, D., Kawamura, T., Horiguchi, N. ... Ohmiya, N. (2017). Histological evaluations of primary lesions are independently associated with prognosis in patients with gastric cancer who receive neoadjuvant chemotherapy. Oncology Letters, 13, 4892-4896. https://doi.org/10.3892/ol.2017.6040
MLA
Tahara, T., Shibata, T., Okubo, M., Yoshida, D., Kawamura, T., Horiguchi, N., Ishizuka, T., Nagasaka, M., Nakagawa, Y., Ohmiya, N."Histological evaluations of primary lesions are independently associated with prognosis in patients with gastric cancer who receive neoadjuvant chemotherapy". Oncology Letters 13.6 (2017): 4892-4896.
Chicago
Tahara, T., Shibata, T., Okubo, M., Yoshida, D., Kawamura, T., Horiguchi, N., Ishizuka, T., Nagasaka, M., Nakagawa, Y., Ohmiya, N."Histological evaluations of primary lesions are independently associated with prognosis in patients with gastric cancer who receive neoadjuvant chemotherapy". Oncology Letters 13, no. 6 (2017): 4892-4896. https://doi.org/10.3892/ol.2017.6040