1
|
Ferlay J, Shin HR, Bray F, Forman D,
Mathers C and Parkin DM: Estimates of worldwide burden of cancer in
2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI
|
2
|
Fock KM: Review article: The epidemiology
and prevention of gastric cancer. Aliment Pharmacol Ther.
40:250–260. 2014. View Article : Google Scholar : PubMed/NCBI
|
3
|
Dai ZJ, Gao J, Ji ZZ, Wang XJ, Ren HT, Liu
XX, Wu WY, Kang HF and Guan HT: Matrine induces apoptosis in
gastric carcinoma cells via alteration of Fas/FasL and activation
of caspase-3. J Ethnopharmacol. 123:91–96. 2009. View Article : Google Scholar : PubMed/NCBI
|
4
|
Oh JH, Lee TJ, Kim SH, Choi YH, Lee SH,
Lee JM, Kim YH, Park JW and Kwon TK: Induction of apoptosis by
withaferin A in human leukemia U937 cells through down-regulation
of Akt phosphorylation. Apoptosis. 13:1494–1504. 2008. View Article : Google Scholar : PubMed/NCBI
|
5
|
Mirjalili MH, Moyano E, Bonfill M, Cusido
RM and Palazón J: Steroidal lactones from Withania somnifera, an
ancient plant for novel medicine. Molecules. 14:2373–2393. 2009.
View Article : Google Scholar : PubMed/NCBI
|
6
|
Palliyaguru DL, Singh SV and Kensler TW:
Withania somnifera: From prevention to treatment of cancer. Mol
Nutr Food Res. 60:1342–1353. 2016. View Article : Google Scholar : PubMed/NCBI
|
7
|
Hahm ER and Singh SV: Withaferin A-induced
apoptosis in human breast cancer cells is associated with
suppression of inhibitor of apoptosis family protein expression.
Cancer Lett. 334:101–108. 2013. View Article : Google Scholar : PubMed/NCBI
|
8
|
Roy RV, Suman S, Das TP, Luevano JE and
Damodaran C: Withaferin A, a steroidal lactone from Withania
somnifera, induces mitotic catastrophe and growth arrest in
prostate cancer cells. J Nat Prod. 76:1909–1915. 2013. View Article : Google Scholar : PubMed/NCBI
|
9
|
Cai Y, Sheng ZY, Chen Y and Bai C: Effect
of Withaferin A on A549 cellular proliferation and apoptosis in
non-small cell lung cancer. Asian Pac J Cancer Prev. 15:1711–1714.
2014. View Article : Google Scholar : PubMed/NCBI
|
10
|
Senthil K, Jayakodi M,
Thirugnanasambantham P, Lee SC, Duraisamy P, Purushotham PM,
Rajasekaran K, Charles S Nancy, Roy I Mariam, Nagappan AK, et al:
Transcriptome analysis reveals in vitro cultured Withania somnifera
leaf and root tissues as a promising source for targeted
withanolide biosynthesis. BMC Genomics. 16:142015. View Article : Google Scholar : PubMed/NCBI
|
11
|
Kim G, Kim TH, Kang MJ, Choi JA, Pack DY,
Lee IR, Kim MG, Han SS, Kim BY, Oh SM, et al: Inhibitory effect of
withaferin A on Helicobacter pylori-induced IL8 production and NFκB
activation in gastric epithelial cells. Mol Med Rep. 13:967–972.
2016.PubMed/NCBI
|
12
|
Kim JE, Lee JY, Kang MJ, Jeong YJ, Choi
JA, Oh SM, Lee KB and Park JH: Withaferin A inhibits helicobacter
pylori-induced production of IL-1β in dendritic cells by regulating
NF-κB and NLRP3 inflammasome activation. Immune Netw. 15:269–277.
2015. View Article : Google Scholar : PubMed/NCBI
|
13
|
Fejzo MS, Anderson L, Chen HW, Anghel A,
Zhuo J, Anchoori R, Roden R and Slamon DJ: ADRM1-amplified
metastasis gene in gastric cancer. Genes Chromosomes Cancer. Jun
6–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
|
14
|
Lin SH and Shih YW: Antitumor effects of
the flavone chalcone: Inhibition of invasion and migration through
the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS
cells. Mol Cell Biochem. 391:47–58. 2014. View Article : Google Scholar : PubMed/NCBI
|
15
|
Pal AD, Basak NP, Banerjee AS and Banerjee
S: Epstein-Barr virus latent membrane protein-2A alters
mitochondrial dynamics promoting cellular migration mediated by
Notch signaling pathway. Carcinogenesis. 35:1592–1601. 2014.
View Article : Google Scholar : PubMed/NCBI
|
16
|
King KL and Cidlowski JA: Cell cycle
regulation and apoptosis. Annu Rev Physiol. 60:601–617. 1998.
View Article : Google Scholar : PubMed/NCBI
|
17
|
Stark GR and Taylor WR: Control of the
G2/M transition. Mol Biotechnol. 32:227–248. 2006. View Article : Google Scholar : PubMed/NCBI
|
18
|
Mayola E, Gallerne C, Esposti DD, Martel
C, Pervaiz S, Larue L, Debuire B, Lemoine A, Brenner C and Lemaire
C: Withaferin A induces apoptosis in human melanoma cells through
generation of reactive oxygen species and down-regulation of Bcl-2.
Apoptosis. 16:1014–1027. 2011. View Article : Google Scholar : PubMed/NCBI
|
19
|
Zhang X, Samadi AK, Roby KF, Timmermann B
and Cohen MS: Inhibition of cell growth and induction of apoptosis
in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural
withanolide Withaferin A. Gynecol Oncol. 124:606–612. 2012.
View Article : Google Scholar : PubMed/NCBI
|
20
|
Malik F, Kumar A, Bhushan S, Khan S,
Bhatia A, Suri KA, Qazi GN and Singh J: Reactive oxygen species
generation and mitochondrial dysfunction in the apoptotic cell
death of human myeloid leukemia HL-60 cells by a dietary compound
withaferin A with concomitant protection by N-acetyl cysteine.
Apoptosis. 12:2115–2133. 2007. View Article : Google Scholar : PubMed/NCBI
|
21
|
Yang ES, Choi MJ, Kim JH, Choi KS and Kwon
TK: Withaferin A enhances radiation-induced apoptosis in Caki cells
through induction of reactive oxygen species, Bcl-2 downregulation
and Akt inhibition. Chem Biol Interact. 190:9–15. 2011. View Article : Google Scholar : PubMed/NCBI
|
22
|
Um HJ, Min KJ, Kim DE and Kwon TK:
Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of
human renal carcinoma Caki cells. Biochem Biophys Res Commun.
427:24–29. 2012. View Article : Google Scholar : PubMed/NCBI
|
23
|
Choi MJ, Park EJ, Min KJ, Park JW and Kwon
TK: Endoplasmic reticulum stress mediates withaferin A-induced
apoptosis in human renal carcinoma cells. Toxicol In Vitro.
25:692–698. 2011. View Article : Google Scholar : PubMed/NCBI
|
24
|
Mandal C, Dutta A, Mallick A, Chandra S,
Misra L, Sangwan RS and Mandal C: Withaferin A induces apoptosis by
activating p38 mitogen-activated protein kinase signaling cascade
in leukemic cells of lymphoid and myeloid origin through
mitochondrial death cascade. Apoptosis. 13:1450–1464. 2008.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Grogan PT, Sleder KD, Samadi AK, Zhang H,
Timmermann BN and Cohen MS: Cytotoxicity of withaferin A in
glioblastomas involves induction of an oxidative stress-mediated
heat shock response while altering Akt/mTOR and MAPK signaling
pathways. Invest New Drugs. 31:545–557. 2013. View Article : Google Scholar : PubMed/NCBI
|
26
|
Hahm ER, Lee J and Singh SV: Role of
mitogen-activated protein kinases and Mcl-1 in apoptosis induction
by withaferin A in human breast cancer cells. Mol Carcinog.
53:907–916. 2014. View
Article : Google Scholar : PubMed/NCBI
|
27
|
Okamoto S, Tsujioka T, Suemori SI, Kida J,
Kondo T, Tohyama Y and Tohyama K: Withaferin A suppresses the
growth of myelodysplasia and leukemia cell lines by inhibiting cell
cycle progression. Cancer Sci. 107:1302–1314. 2016. View Article : Google Scholar : PubMed/NCBI
|
28
|
Samadi AK, Cohen SM, Mukerji R, Chaguturu
V, Zhang X, Timmermann BN, Cohen MS and Person EA: Natural
withanolide withaferin A induces apoptosis in uveal melanoma cells
by suppression of Akt and c-MET activation. Tumour Biol.
33:1179–1189. 2012. View Article : Google Scholar : PubMed/NCBI
|
29
|
Antony ML, Lee J, Hahm ER, Kim SH, Marcus
AI, Kumari V, Ji X, Yang Z, Vowell CL, Wipf P, et al: Growth arrest
by the antitumor steroidal lactone withaferin A in human breast
cancer cells is associated with down-regulation and covalent
binding at cysteine 303 of β-tubulin. J Biol Chem. 289:1852–1865.
2014. View Article : Google Scholar : PubMed/NCBI
|
30
|
Munagala R, Kausar H, Munjal C and Gupta
RC: Withaferin A induces p53-dependent apoptosis by repression of
HPV oncogenes and upregulation of tumor suppressor proteins in
human cervical cancer cells. Carcinogenesis. 32:1697–1705. 2011.
View Article : Google Scholar : PubMed/NCBI
|
31
|
Stan SD, Zeng Y and Singh SV: Ayurvedic
medicine constituent withaferin a causes G2 and M phase cell cycle
arrest in human breast cancer cells. Nutr Cancer. 60 Suppl
1:S51–S60. 2008. View Article : Google Scholar
|
32
|
Thaiparambil JT, Bender L, Ganesh T, Kline
E, Patel P, Liu Y, Tighiouart M, Vertino PM, Harvey RD, Garcia A
and Marcus AI: Withaferin A inhibits breast cancer invasion and
metastasis at sub-cytotoxic doses by inducing vimentin disassembly
and serine 56 phosphorylation. Int J Cancer. 129:2744–2755. 2011.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Fuyuhiro Y, Yashiro M, Noda S, Kashiwagi
S, Matsuoka J, Doi Y, Kato Y, Kubo N, Ohira M and Hirakawa K:
Clinical significance of vimentin-positive gastric cancer cells.
Anticancer Res. 30:5239–5243. 2010.PubMed/NCBI
|
34
|
Chen YR, Juan HF, Huang HC, Huang HH, Lee
YJ, Liao MY, Tseng CW, Lin LL, Chen JY, Wang MJ, et al:
Quantitative proteomic and genomic profiling reveals
metastasis-related protein expression patterns in gastric cancer
cells. J Proteome Res. 5:2727–2742. 2006. View Article : Google Scholar : PubMed/NCBI
|
35
|
Bargagna-Mohan P, Hamza A, Kim YE, Ho Y
Khuan Abby, Mor-Vaknin N, Wendschlag N, Liu J, Evans RM, Markovitz
DM, Zhan CG, et al: The tumor inhibitor and antiangiogenic agent
withaferin A targets the intermediate filament protein vimentin.
Chem Biol. 14:623–634. 2007. View Article : Google Scholar : PubMed/NCBI
|
36
|
Shen W, Xi H, Wei B and Chen L: The
prognostic role of matrix metalloproteinase 2 in gastric cancer: A
systematic review with meta-analysis. J Cancer Res Clin Oncol.
140:1003–1009. 2014. View Article : Google Scholar : PubMed/NCBI
|
37
|
Parsons SL, Watson SA, Collins HM, Griffin
NR, Clarke PA and Steele RJ: Gelatinase (MMP-2 and -9) expression
in gastrointestinal malignancy. Br J Cancer. 78:1495–1502. 1998.
View Article : Google Scholar : PubMed/NCBI
|
38
|
Lee DH, Lim IH, Sung EG, Kim JY, Song IH,
Park YK and Lee TJ: Withaferin A inhibits matrix
metalloproteinase-9 activity by suppressing the Akt signaling
pathway. Oncol Rep. 30:933–938. 2013.PubMed/NCBI
|
39
|
Rayburn ER, Ezell SJ and Zhang R:
Anti-Inflammatory agents for cancer therapy. Mol Cell Pharmacol.
1:29–43. 2009. View Article : Google Scholar : PubMed/NCBI
|
40
|
Wroblewski LE, Peek RM Jr and Wilson KT:
Helicobacter pylori and gastric cancer: Factors that modulate
disease risk. Clin Microbiol Rev. 23:713–739. 2010. View Article : Google Scholar : PubMed/NCBI
|
41
|
Kitadai Y, Sasaki A, Ito M, Tanaka S, Oue
N, Yasui W, Aihara M, Imagawa K, Haruma K and Chayama K:
Helicobacter pylori infection influences expression of genes
related to angiogenesis and invasion in human gastric carcinoma
cells. Biochem Biophys Res Commun. 311:809–814. 2003. View Article : Google Scholar : PubMed/NCBI
|
42
|
Strowski MZ, Cramer T, Schäfer G, Jüttner
S, Walduck A, Schipani E, Kemmner W, Wessler S, Wunder C, Weber M,
et al: Helicobacter pylori stimulates host vascular endothelial
growth factor-A (vegf-A) gene expression via MEK/ERK-dependent
activation of Sp1 and Sp3. FASEB J. 18:218–220. 2004.PubMed/NCBI
|