Voltage-gated calcium channels: Novel targets for cancer therapy
- Authors:
- Nam Nhut Phan
- Chih‑Yang Wang
- Chien‑Fu Chen
- Zhengda Sun
- Ming‑Derg Lai
- Yen‑Chang Lin
-
Affiliations: Faculty of Applied Sciences, Ton Duc Thang University, Tan Phong Ward, Ho Chi Minh 700000, Vietnam, Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan, R.O.C., School of Chinese Medicine for Post‑Baccalaureate, I‑Shou University, Kaohsiung 84001, Taiwan, R.O.C., Department of Radiology, University of California, San Francisco, CA 94143, USA, Graduate Institute of Biotechnology, Chinese Culture University, Taipei 1114, Taiwan, R.O.C. - Published online on: June 22, 2017 https://doi.org/10.3892/ol.2017.6457
- Pages: 2059-2074
-
Copyright: © Phan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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|
Sarkar P and Kumar S: Calcium sensing receptor modulation for cancer therapy. Asian Pac J Cancer Prev. 13:3561–3568. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lang F, Föller M, Lang KS, Lang PA, Ritter M, Gulbins E, Vereninov A and Huber SM: Ion channels in cell proliferation and apoptotic cell death. J Membr Biol. 205:147–157. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Cuddapah VA and Sontheimer H: Ion channels and tranporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration. Am J Physiol Cell Physiol. 301:C541–C549. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Long J, Zhang ZB, Liu Z, Xu YH and Ge CL: Loss of heterozygosity at the calcium regulation gene locus on chromosome 10q in human pancreatic cancer. Asian Pac J Cancer Prev. 16:2489–2493. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Azimi I, Roberts-Thomson SJ and Monteith GR: Calcium influx pathways in breast cancer: Opportunities for pharmacological intervention. Br J Pharmacol. 171:945–960. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Loughlin KR: Calcium channel blockers and prostate cancer. Urol Oncol. 32:537–538. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Q, Zhang Q, Zhong F, Guo S, Jin Z, Shi W, Chen C and He J: Association between calcium channel blockers and breast cancer: A meta-analysis of observational studies. Pharmacoepidemiol Drug Saf. 23:711–718. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
George GP, Ramesh V and Mittal RD: Impact of total and ionized serum calcium on prostate cancer risk in North Indian men. Asian Pac J Cancer Prev. 12:1257–1260. 2011.PubMed/NCBI | |
|
Mahmoudi T, Karimi K, Arkani M, Farahani H, Nobakht H, Dabiri R, Asadi A and Zali MR: Parathyroid hormone gene rs6256 and calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer in Iran. Asian Pac J Cancer Prev. 15:6035–6039. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR and Golub TR: Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nat Genet. 36:257–263. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, et al: Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature. 415:436–442. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, et al: The mutational landscape of lethal castration-resistant prostate cancer. Nature. 487:239–243. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Storz MN, van de Rijn M, Kim YH, Mraz-Gernhard S, Hoppe RT and Kohler S: Gene expression profiles of cutaneous B cell lymphoma. J Invest Dermatol. 120:865–870. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F, Ozbun L, Brady J, Barrett JC, Boyd J and Birrer MJ: A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res. 68:5478–5486. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, et al: Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 42:715–721. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Skotheim RI, Lind GE, Monni O, Nesland JM, Abeler VM, Fosså SD, Duale N, Brunborg G, Kallioniemi O, Andrews PW and Lothe RA: Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development. Cancer Res. 65:5588–5598. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Cutcliffe C, Kersey D, Huang CC, Zeng Y, Walterhouse D and Perlman EJ; Renal Tumor Committee of the Children's Oncology Group, : Clear cell sarcoma of the kidney: Up-regulation of neural markers with activation of the sonic hedgehog and Akt pathways. Clin Cancer Res. 11:7986–7994. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H, Chen H, Omeroglu G, Meterissian S, Omeroglu A, et al: Stromal gene expression predicts clinical outcome in breast cancer. Nat Med. 14:518–527. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Crabtree JS, Jelinsky SA, Harris HA, Choe SE, Cotreau MM, Kimberland ML, Wilson E, Saraf KA, Liu W, McCampbell AS, et al: Comparison of human and rat uterine leiomyomata: Identification of a dysregulated mammalian target of rapamycin pathway. Cancer Res. 69:6171–6178. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Hao Y, Triadafilopoulos G, Sahbaie P, Young HS, Omary MB and Lowe AW: Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma. Gastroenterology. 131:925–933. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Szatkowski C, Parys JB, Ouadid-Ahidouch H and Matifat F: Research Inositol 1,4,5-trisphosphate-induced Ca2+ signalling is involved in estradiol-induced breast cancer epithelial cell growth. Mol Cancer. 9:1562010. View Article : Google Scholar : PubMed/NCBI | |
|
Mariot P, Prevarskaya N, Roudbaraki MM, Le Bourhis X, Van Coppenolle F, Vanoverberghe K and Skryma R: Evidence of functional ryanodine receptor involved in apoptosis of prostate cancer (LNCaP) cells. Prostate. 43:205–214. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X and Zhu MX: The acid test: The discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels. Pflugers Arch. 458:869–876. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Lipkin M and Newmark H: Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med. 313:1381–1384. 1985. View Article : Google Scholar : PubMed/NCBI | |
|
Jin T, Zhang Z, Yang XF and Luo JS: S100A4 expression is closely linked to genesis and progression of glioma by regulating proliferation, apoptosis, migration and invasion. Asian Pac J Cancer Prev. 16:2883–2887. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Berridge MJ, Bootman MD and Roderick HL: Calcium signalling: Dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 4:517–529. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Takeshige N, Yin G, Ohnaka K, Kono S, Ueki T, Tanaka M, Maehara Y, Okamura T, Ikejiri K, Maekawa T, et al: Associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk and effect modifications of dietary calcium and vitamin D in a Japanese population. Asian Pac J Cancer Prev. 16:2019–2026. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Panner A and Wurster RD: T-type calcium channels and tumor proliferation. Cell Calcium. 40:253–259. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL and Simons JW: Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59:5830–5835. 1999.PubMed/NCBI | |
|
Linja MJ, Savinainen KJ, Saramäki OR, Tammela TL, Vessella RL and Visakorpi T: Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer. Cancer Res. 61:3550–3555. 2001.PubMed/NCBI | |
|
Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D and Peters G: Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res. 54:1812–1817. 1994.PubMed/NCBI | |
|
Cole S, Bhardwaj G, Gerlach J, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM and Deeley RG: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 258:1650–1654. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Liu TH, Guo K, Liu RQ, Zhang S, Huang ZH and Liu YK: The high expressed serum soluble neural cell adhesion molecule, a high risk factor indicating hepatic encephalopathy in hepatocelular carcinoma patients. Asian Pac J Cancer Prev. 16:3131–3135. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Mao YY, Jing FY, Jin MJ, Li YJ, Ding Y, Guo J, Wang FJ, Jiang LF and Chen K: rs12904 polymorphism in the 3′UTR of EFNA1 is associated with colorectal cancer susceptibility in a Chinese population. Asian Pac J Cancer Prev. 14:5037–5041. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Martino-Echarri E, Fernández-Rodríguez R, Rodríguez-Baena FJ, Barrientos-Durán A, Torres-Collado AX, Plaza-Calonge Mdel C, Amador-Cubero S, Cortés J, Reynolds LE, Hodivala-Dilke KM and Rodríguez-Manzaneque JC: Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2. Int J Cancer Cancer Cancer. 133:2315–2324. 2013. View Article : Google Scholar | |
|
Li YP, Tian FG, Shi PC, Guo LY, Wu HM, Chen RQ and Xue JM: 4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1α stabilization. Asian Pac J Cancer Prev. 15:10151–10156. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, et al: SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 17:41–52. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Dziegielewska B, Gray LS and Dziegielewski J: T-type calcium channels blockers as new tools in cancer therapies. Pflugers Arch. 466:801–810. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JY, Park SJ, Park SJ, Lee MJ, Rhim H, Seo SH and Kim KS: Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers. Bioorg Med Chem Lett. 16:5014–5017. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Bertolesi GE, Shi CJ, Elbaum L, Jollimore C, Rozenberg G, Barnes S and Kelly ME: The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol. 62:210–219. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Toyota M, Ho C, Ohe-Toyota M, Baylin SB and Issa JP: Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5′ CpG island in human tumors. Cancer Res. 59:4535–4541. 1999.PubMed/NCBI | |
|
Díaz-Lezama N, Hernández-Elvira M, Sandoval A, Monroy A, Felix R and Monjaraz E: Ghrelin inhibits proliferation and increases T-type Ca2+ channel expression in PC-3 human prostate carcinoma cells. Biochem Biophys Res Commun. 403:24–29. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wang CY, Lai MD, Phan NN, Sun ZD and Lin YC: Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancer patients. PLoS One. 10:e01257662015. View Article : Google Scholar : PubMed/NCBI | |
|
Rhodes DR and Chinnaiyan AM: Integrative analysis of the cancer transcriptome. Nat Genet. 37 Suppl:S31–S37. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou C, Ren Y, Wang K, Liu J, He JJ and Liu PJ: Intra-operative rectal washout with saline solution can effectively prevent anastomotic recurrence: A meta-analysis. Asian Pac J Cancer Prev. 14:7155–7159. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Alqumber MA, Dar SA, Haque S, Wahid M, Singh R and Akhter N: No association of the TGF-β1 29T/C polymorphism with breast cancer risk in caucasian and Asian populations: Evidence from a meta-analysis involving 55, 841 subjects. Asian Pac J Cancer Prev. 15:8725–8734. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS and Brown M: Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell. 20:119–131. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
D'Ambrogio A, Nagaoka K and Richter JD: Translational control of cell growth and malignancy by the CPEBs. Nat Rev Cancer. 13:283–290. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, et al: The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483:603–607. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Ertel EA, Campbell KP, Harpold MM, Hofmann F, Mori Y, Perez-Reyes E, Schwartz A, Snutch TP, Tanabe T, Birnbaumer L, et al: Nomenclature of voltage-gated calcium channels. Neuron. 25:533–535. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Cain SM and Snutch TP: Voltage-gated calcium channels and disease. Biofactors. 37:197–205. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Bidaud I, Mezghrani A, Swayne LA, Monteil A and Lory P: Voltage-gated calcium channels in genetic diseases. Biochim Biophys Acta. 1763:1169–1174. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Kavianpour M, Ahmadzadeh A, Shahrabi S and Saki N: Significance of oncogenes and tumor suppressor genes in AML prognosis. Tumour Biol. 37:10041–10052. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Cooper GM and Hausman RE: The cell. Sinauer Associates Sunderland; 2000, PubMed/NCBI | |
|
Sanchez-Carbayo M, Socci ND, Lozano J, Saint F and Cordon-Cardo C: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol. 24:778–789. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Marta SC, Nicholas S, Juanjo L, Fabien S and Carlos CC: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. Tumor Biol. 27:47. 2006. | |
|
Schaldemose EL, Horjales-Araujo E, Demontis D, Børglum AD, Svensson P and Finnerup NB: No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals. Mol Pain. 10:762014. View Article : Google Scholar : PubMed/NCBI | |
|
Stunnenberg BC, Deinum J, Links TP, Wilde AA, Franssen H and Drost G: Cardiac arrhythmias in hypokalemic periodic paralysis: Hypokalemia as only cause? Muscle Nerve. 50:327–332. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Beitelshees AL, Navare H, Wang D, Gong Y, Wessel J, Moss JI, Langaee TY, Cooper-DeHoff RM, Sadee W, Pepine CJ, et al: CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response. Circ Cardiovasc Genet. 2:362–370. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nürnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, et al: Loss of Cav1. 3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness. Nat Neurosci. 14:77–84. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Johnson AD, Newton-Cheh C, Chasman DI, Ehret GB, Johnson T, Rose L, Rice K, Verwoert GC, Launer LJ, Gudnason V, et al: Association of hypertension drug target genes with blood pressure and hypertension in 86 588 individuals. Hypertension. 57:903–910. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Madden E: Differential gene remodeling in overweight and obese patients with heart failure. 2013. | |
|
Kang H, Yang X, Chen R, Zhang B, Corona E, Schadt EE and Butte AJ: Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. Diabetologia. 55:2205–2213. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Reinbothe TM, Alkayyali S, Ahlqvist E, Tuomi T, Isomaa B, Lyssenko V and Renström E: The human L-type calcium channel Cav1. 3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes. Diabetologia. 56:340–349. 2013. | |
|
Reinbothe T, Lyssenko V, Lang S and Renström E: Polymorphisms in CACNA1D affect insulin release and channel expression and associate with type 2 diabetes46th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Springer; pp. 2962010; | |
|
Qiu ZX, Zhao S, Li L and Li WM: Loss of expression of PTEN is associated with worse prognosis in patients with cancer. Asian Pac J Cancer Prev. 16:4691–4698. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kamp TJ and Hell JW: Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Cir Res. 87:1095–1102. 2000. View Article : Google Scholar | |
|
Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F and Klugbauer N: Dominant role of smooth muscle L-type calcium channel Cav1. 2 for blood pressure regulation. EMBO J. 22:6027–6034. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Bhat S, Dao DT, Terrillion CE, Arad M, Smith RJ, Soldatov NM and Gould TD: CACNA1C (Ca v 1.2) in the pathophysiology of psychiatric disease. Prog Neurobiol. 99:1–14. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Sun L, Hui AM, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S, Passaniti A, Menon J, Walling J, Bailey R, et al: Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell. 9:287–300. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Murat A, Migliavacca E, Gorlia T, Lambiv WL, Shay T, Hamou MF, de Tribolet N, Regli L, Wick W, Kouwenhoven MC, et al: Stem cell-related ‘self-renewal’ signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol. 26:3015–3024. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Uchitel OD, Protti DA, Sanchez V, Cherksey BD, Sugimori M and Llinás R: P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses. Proc Natl Acad Sci USA. 89:pp. 3330–3333. 1992; View Article : Google Scholar : PubMed/NCBI | |
|
Catterall WA: Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release. Cell Calcium. 24:307–323. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Piccaluga PP, Agostinelli C, Califano A, Rossi M, Basso K, Zupo S, Went P, Klein U, Zinzani PL, Baccarani M, et al: Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets. J Clin Invest. 117:823–834. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Gazulla J and Tintore M: P/Q-type voltage-dependent calcium channels in neurological disease. Neurologia. 22:511–516. 2007.(In Spanish). PubMed/NCBI | |
|
Jensen RL, Petr M and Wurster RD: Calcium channel antagonist effect on in vitro meningioma signal transduction pathways after growth factor stimulation. Neurosurgery. 46:692–703. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Lee YS, Sayeed MM and Wurster RD: Inhibition of cell growth and intracellular Ca2+ mobilization in human brain tumor cells by Ca2+ channel antagonists. Mol Chem Neuropathol. 22:81–95. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Jensen RL, Origitano TC, Lee YS, Weber M and Wurster RD: In vitro growth inhibition of growth factor-stimulated meningioma cells by calcium channel antagonists. Neurosurgery. 36:365–374. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Latour I, Louw DF, Beedle AM, Hamid J, Sutherland GR and Zamponi GW: Expression of T-type calcium channel splice variants in human glioma. Glia. 48:112–119. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Schorge S and Rajakulendran S: The P/Q channel in human disease: untangling the genetics and physiology. WIREs Membr Transp Signal. 1:311–320. 2012. View Article : Google Scholar | |
|
Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, Lamerdin JE, Mohrenweiser HW, Bulman DE, Ferrari M, et al: Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 87:543–552. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Zhuchenko O, Bailey J, Bonnen P, Ashizawa T, Stockton DW, Amos C, Dobyns WB, Subramony SH, Zoghbi HY, Lee CC, et al: Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha1A-voltage-dependent calcium channel. Nat Genet. 15:62–69. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Bürk K, Kaiser FJ, Tennstedt S, Schöls L, Kreuz FR, Wieland T, Strom TM, Büttner T, Hollstein R, Braunholz D, et al: A novel missense mutation in CACNA1A evaluated by in silico protein modeling is associated with non-episodic spinocerebellar ataxia with slow progression. Eur J Med Genet. 57:207–211. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Sintas C, Carreño O, Corominas R, Serra SA, Vila M, Fernández-Castillo N, Toma C, Pons R, Llaneza M, Sobrido MJ, et al: Screening of cacna1a and ATP1A2 genes in hemiplegic migraine: Clinical, genetic and functional studies. J Headache Pain. 14 Suppl 1:P262013. View Article : Google Scholar | |
|
Verschuur-Maes AH, de Bruin PC and van Diest PJ: Epigenetic progression of columnar cell lesions of the breast to invasive breast cancer. Breast Cancer Res Treat. 136:705–715. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Castro M, Grau L, Puerta P, Gimenez L, Venditti J, Quadrelli S and Sánchez-Carbayo M: Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer. J Transl Med. 8:862010. View Article : Google Scholar : PubMed/NCBI | |
|
Burger PC, Yu I, Tihan T, et al: Atypical teratoid/rhabdoid tumor of the central nervous system: A highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: A pediatric oncology group study. Am J Surg Pathol. 22:1083–1092. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Roderick HL and Cook SJ: Ca2+ signalling checkpoints in cancer: Remodelling Ca2+ for cancer cell proliferation and survival. Nat Rev Cancer. 8:361–375. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Tomlins SA, Laxman B, Varambally S, Cao X, Yu J, Helgeson BE, Cao Q, Prensner JR, Rubin MA, Shah RB, et al: Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia. 10:177–188. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Chen R, Zeng X, Zhang R, Huang J, Kuang X, Yang J, Liu J, Tawfik O, Thrasher JB and Li B: Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers. Urol Oncol. 32:524–536. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Christudass C, Zhang H, et al: A novel quantitative histomorphological tool to assess multiple biomarkers to predict prostate cancer aggression. Cancer Res. 74 19 Suppl:S40132014. View Article : Google Scholar | |
|
Ricci M, Xu Y, Hammond HL, Willoughby DA, Nathanson L, Rodriguez MM, Vatta M, Lipshultz SE and Lincoln J: Myocardial alternative RNA splicing and gene expression profiling in early stage hypoplastic left heart syndrome. PLoS One. 7:e297842012. View Article : Google Scholar : PubMed/NCBI | |
|
Dutton Regester K and Hayward NK: Reviewing the somatic genetics of melanoma: From current to future analytical approaches. Pigment Cell Melanoma Res. 25:144–154. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, et al: Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res. 11:5730–5739. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, Pambuccian SE, Ondrey FG, Adams GL and Gaffney PM: Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res. 64:55–63. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Estilo CL, O-charoenrat P, Talbot S, Socci ND, Carlson DL, Ghossein R, Williams T, Yonekawa Y, Ramanathan Y, Boyle JO, et al: Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis. BMC Cancer. 9:112009. View Article : Google Scholar : PubMed/NCBI | |
|
Talbot SG, Estilo C, Maghami E, Sarkaria IS, Pham DK, O-charoenrat P, Socci ND, Ngai I, Carlson D, Ghossein R, et al: Gene expression profiling allows distinction between primary and metastatic squamous cell carcinomas in the lung. Cancer Res. 65:3063–3071. 2005.PubMed/NCBI | |
|
Basso K, Margolin AA, Stolovitzky G, Klein U, Dalla-Favera R and Califano A: Reverse engineering of regulatory networks in human B cells. Nat Genet. 37:382–390. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Yoshihara K, Tajima A, Komata D, et al: Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis. Cancer Sci. 100:1421–1428. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Sanchez-Carbayo M, Socci ND, Lozano J, Saint F and Cordon-Cardo C: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol. 24:778–789. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Tomlins SA, Mehra R, Rhodes DR, et al: Integrative molecular concept modeling of prostate cancer progression. Nat Genet. 39:41–51. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Yusenko MV, Kuiper RP, Boethe T, Ljungberg B, van Kessel AG and Kovacs G: High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas. BMC Cancer. 9:1522009. View Article : Google Scholar : PubMed/NCBI | |
|
Frierson HF Jr, El-Naggar AK, Welsh JB, Sapinoso LM, Su AI, Cheng J, Saku T, Moskaluk CA and Hampton GM: Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol. 161:1315–1323. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Biewenga P, Buist MR, Moerland PD, Ver Loren van Themaat E, van Kampen AH, ten Kate FJ and Baas F: Gene expression in early stage cervical cancer. Gynecol Oncol. 108:520–526. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Aerts J, den Hamer B, van Ijcken W, den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, et al: Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One. 5:e103122010. View Article : Google Scholar : PubMed/NCBI | |
|
Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, et al: Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res. 72:100–111. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wurmbach E, Chen YB, Khitrov G, Zhang W, Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J, et al: Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology. 45:938–947. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA and Yoon SS: Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A. Cancer Res. 65:5881–5889. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Rickman DS, Bobek MP, Misek DE, Kuick R, Blaivas M, Kurnit DM, Taylor J and Hanash SM: Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis. Cancer Res. 61:6885–6891. 2001.PubMed/NCBI | |
|
Shai R, Shi T, Kremen TJ, Horvath S, Liau LM, Cloughesy TF, Mischel PS and Nelson SF: Gene expression profiling identifies molecular subtypes of gliomas. Oncogene. 22:4918–4923. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Hong Y, Downey T, Eu KW, Koh PK and Cheah PY: A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Clin Exp Metastasis. 27:83–90. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Sabates-Bellver J, van der Flier LG, de Palo M, et al: Transcriptome profile of human colorectal adenomas. Mol Cancer Res. 5:1263–1275. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
D'Errico M, de Rinaldis E, Blasi MF, Viti V, Falchetti M, Calcagnile A, Sera F, Saieva C, Ottini L, Palli D, et al: Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. Eur J Cancer. 45:461–469. 2009. View Article : Google Scholar | |
|
Turashvili G, Bouchal J, Baumforth K, Wei W, Dziechciarkova M, Ehrmann J, Klein J, Fridman E, Skarda J, Srovnal J, et al: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer. 7:552007. View Article : Google Scholar : PubMed/NCBI | |
|
Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, Pastorino S, Purow BW, Christopher N, Zhang W, et al: Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell. 9:391–403. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JS, Leem SH, Lee SY, Kim SC, Park ES, Kim SB, Kim SK, Kim YJ, Kim WJ and Chu IS: Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. J Clin Oncol. 28:2660–2667. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Beheshti J, Bueno R, Gillette M, et al: Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA. 98:pp. 13790–13795. 2001; View Article : Google Scholar : PubMed/NCBI | |
|
Gluck S, Ross JS, Royce M, McKenna EF Jr, Perou CM, Avisar E and Wu L: TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine ± trastuzumab. Breast Cancer Res Treat. 132:781–791. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
French PJ, Swagemakers SM, Nagel JH, Kouwenhoven MC, Brouwer E, van der Spek P, Luider TM, Kros JM, van den Bent MJ and Smitt PA Sillevis: Gene expression profiles associated with treatment response in oligodendrogliomas. Cancer Res. 65:11335–11344. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Q, Wen YG, Li DP, Xia J, Zhou CZ, Yan DW, Tang HM and Peng ZH: Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol. 29:77–83. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Haslinger C, Schweifer N, Stilgenbauer S, Döhner H, Lichter P, Kraut N, Stratowa C and Abseher R: Microarray gene expression profiling of B-cell chronic lymphocytic leukemia subgroups defined by genomic aberrations and VH mutation status. J Clin Oncol. 22:3937–3949. 2004. View Article : Google Scholar : PubMed/NCBI |
