Diagnosis and surgical treatment of retroperitoneal paraganglioma: A single-institution experience of 34 cases

Ji,Xiao‑Ke; Zheng,Xiang‑Wu; Wu,Xiu‑Lin; Yu,Zheng‑Ping; Shan,Yun‑Feng; Zhang,Qi‑Yu; Zeng,Qi‑Qiang

doi:10.3892/ol.2017.6468

Diagnosis and surgical treatment of retroperitoneal paraganglioma: A single-institution experience of 34 cases

Authors:
- Xiao‑Ke Ji
- Xiang‑Wu Zheng
- Xiu‑Lin Wu
- Zheng‑Ping Yu
- Yun‑Feng Shan
- Qi‑Yu Zhang
- Qi‑Qiang Zeng
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Affiliations: Department of General Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Radiological Department, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Pathology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
Published online on: June 22, 2017 https://doi.org/10.3892/ol.2017.6468
Pages: 2268-2280
Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed at identifying the clinical, radiological and pathological characteristics of retroperitoneal paragangliomas, and determining the association between the tumor features and the prognosis of patients following surgery. A total of 34 patients with retroperitoneal paragangliomas, who underwent resection between November 1999 and December 2015, were included in the present retrospective study. The patients' demographics, clinical symptoms and signs, tumor functional status, surgical procedure, intraoperative results, tumor pathology, radiological results, and postoperative survival time were recorded and analyzed. Of the 34 patients, the most common type of presenting symptom was abdominal mass (46%), followed by hypertension (39%) and abdominal pain (32%). Functional tumors occurred in 20 patients (59%). Computed tomography (CT) and magnetic resonance imaging revealed soft‑tissue masses, with marked enhancement in the arterial phase, indicative of retroperitoneal paragangliomas. The preoperative CT diagnostic accuracy rate between 2010 and 2015 was markedly improved, compared with that between 1999 and 2009. The tumors were primarily located close to the renal arteries and veins surrounding the abdominal aorta and inferior vena cava. With the exception of one malignant paraganglioma, the majority of paragangliomas were positive for chromogranin A, S‑100 protein, vimentin and heat‑shock protein 90, and exhibited decreased expression of Ki‑67 antigen and insulin‑like growth factor 2. All tumors were completely removed by surgery. Distant metastasis, but not tumor size, functional status and local invasion, was markedly associated with survival. The preoperative diagnostic accuracy rate of retroperitoneal paragangliomas may be improved by focusing on the predilection sites and CT characteristics. In addition, immunohistochemical markers were useful to determine tumor malignancy. Complete surgical resection was appropriate for all patients and postoperative survival time was identified to be associated with tumor metastasis.

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